PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKDC	12	CHEK2	2	enzymatic study	Chan DW (2000)	1
RAD9B	1	RAD17	2	affinity chromatography technology	Dufault VM (2003)	1
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
CHEK2	2	CHEK1	2	genetic interference	Srivas R (2016)	1
RAD17	2	POLE4	0	affinity chromatography technology	Post SM (2003)	1
ALK	8	RAD17	2	affinity chromatography technology	Crockett DK (2004)	1
RAD9B	1	HUS1	1	affinity chromatography technology	Dufault VM (2003)	1
USP20	3	RFC3	0	affinity chromatography technology	Sowa ME (2009)	1
RFC3	0	RFC5	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
ATM	9	CHEK1	2	unspecified method, enzymatic study, genetic interference	Kim ST (1999), Sorensen CS (2003), Shen JP (2017)	3
RAD9A	1	RAD17	2	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Bermudez VP (2003), Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Lindsey-Boltz LA (2001), Zhang L (2010)	7
ATR	6	CLSPN	1	affinity chromatography technology	Chini CC (2003)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
ATR	6	USP20	3	affinity chromatography technology	Zhu M (2014)	1
CLSPN	1	HUS1	1	genetic interference	Horlbeck MA (2018)	1
H2AFX	1	RAD17	2	affinity chromatography technology	Tsai WB (2008)	1
RFC1	1	RFC5	2	biochemical, biochemical, biochemical, affinity chromatography technology	Tomida J (2008), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
RAD9A	1	RAD1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Dufault VM (2003), Volkmer E (1999), Volkmer E (1999), Griffith JD (2002), Hirai I (2002), Hirai I (2002), Lindsey-Boltz LA (2001), Huttlin EL (2015), Huttlin EL (2017)	10
CHEK1	2	RAD17	2	genetic interference	Srivas R (2016)	1
TOP1	1	RAD17	2	genetic interference	Srivas R (2016)	1
TOP1	1	ATM	9	unspecified method	Trzcinska AM (2002)	1
CHEK1	2	RFC1	1	genetic interference	Srivas R (2016)	1
RAD17	2	SNU13	0	two hybrid, affinity chromatography technology	Chang MS (1999), Chang MS (1999)	2
RAD17	2	HUS1	1	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Huttlin EL (2015), Huttlin EL (2017)	5
RAD17	2	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Wang X (2006)	2
TOP1	1	CHEK1	2	genetic interference	Srivas R (2016)	1
USP20	3	RFC2	0	affinity chromatography technology	Sowa ME (2009)	1
USP20	3	CLSPN	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yuan J (2014), Yuan J (2014), Yuan J (2014), Yuan J (2014), Zhu M (2014), Zhu M (2014), Zhu M (2014)	7
CBX7	1	USP20	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATR	6	RAD1	0	affinity chromatography technology	Pabla N (2008)	1
USP20	3	RAD17	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sowa ME (2009), Shanmugam I (2014), Shanmugam I (2014), Shanmugam I (2014)	4
RAD9A	1	CLSPN	1	affinity chromatography technology, affinity chromatography technology	Chini CC (2003), Zhang L (2010)	2
POLE2	2	POLE	10	biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2011), Bermudez VP (2011), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Moiseeva TN (2016)	7
RAD17	2	POLE2	2	affinity chromatography technology	Post SM (2003)	1
RAD17	2	RAD1	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Bao S (2001), Bao S (2001)	5
POLE2	2	POLE4	0	pull down, affinity chromatography technology	Li Y (2000), Huttlin EL (2017)	2
PRKDC	12	RAD17	2	unspecified method	Kim ST (1999)	1
POLE2	2	POLE3	0	pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Li Y (2000), Li Y (2000), Bermudez VP (2011), Huttlin EL (2017)	4
CHEK2	2	RAD17	2	genetic interference	Srivas R (2016)	1
RFC1	1	RAD17	2	biochemical, affinity chromatography technology	Tomida J (2008), Dahm K (2002)	2
TOP3A	0	RAD17	2	genetic interference	Srivas R (2016)	1
CBX7	1	RAD17	2	affinity chromatography technology	Vandamme J (2011)	1
POLE4	0	POLE	10	biochemical, affinity chromatography technology	Wan C (2015), Moiseeva TN (2016)	2
USP20	3	RFC4	1	affinity chromatography technology	Sowa ME (2009)	1
TOP3A	0	CHEK1	2	genetic interference	Srivas R (2016)	1
PRKDC	12	CHEK1	2	unspecified method, pull down, genetic interference	Kim ST (1999), Goudelock DM (2003), Shen JP (2017)	3
HUS1	1	POLE2	2	genetic interference	Horlbeck MA (2018)	1
CBX6	1	RAD17	2	affinity chromatography technology	Vandamme J (2011)	1
RAD17	2	PRMT6	2	two hybrid	Weimann M (2013)	1
RFC3	0	RFC1	1	affinity chromatography technology, pull down, biochemical, biochemical, biochemical	Ellison V (1998), Uhlmann F (1996), Tomida J (2008), Havugimana PC (2012), Wan C (2015)	5
RAD17	2	RFC2	0	pull down, affinity chromatography technology	Zou L (2003), Huttlin EL (2017)	2
TOP2A	2	RAD17	2	genetic interference	Srivas R (2016)	1
ATR	6	RAD17	2	unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kim ST (1999), Bao S (2001), Bao S (2001), Bomgarden RD (2004), Zhang L (2010)	5
RAD17	2	RFC4	1	pull down, affinity chromatography technology	Zou L (2003), Huttlin EL (2017)	2
RAD17	2	POLE	10	affinity chromatography technology, pull down	Post SM (2003), Post SM (2003)	2
CHEK1	2	CLSPN	1	pull down, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Chini CC (2003), Chini CC (2003), Chini CC (2006), Chini CC (2006), Chini CC (2006), Huh J (2013), Clarke CA (2005), Clarke CA (2005)	8
HUS1	1	RFC4	1	genetic interference	Horlbeck MA (2018)	1
RFC1	1	RFC4	1	biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Tomida J (2008), Havugimana PC (2012), Uhlmann F (1997), Wan C (2015), Huttlin EL (2017)	5
POLE3	0	POLE4	0	affinity chromatography technology, biochemical, biochemical	Li Y (2000), Havugimana PC (2012), Wan C (2015)	3
RFC2	0	RFC4	1	biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Cai J (1997), Cai J (1998), Havugimana PC (2012), Uhlmann F (1997), Gupte RS (2006), Wan C (2015), Huttlin EL (2017)	7
RFC2	0	RFC5	2	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology	Cai J (1997), Cai J (1998), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
RAD17	2	POLE3	0	affinity chromatography technology	Post SM (2003)	1
RFC3	0	RFC4	1	affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology	Ellison V (1998), Uhlmann F (1996), Havugimana PC (2012), Uhlmann F (1997), Wan C (2015), Huttlin EL (2017)	6
PRKDC	12	H2AFX	1	enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Park EJ (2003), Mischo HE (2005), Heo K (2008), Heo K (2008), Li A (2010), Kim K (2012)	6
HUS1	1	RAD1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Volkmer E (1999), Volkmer E (1999), Hang H (2002), Hirai I (2004), Warmerdam DO (2010), Huttlin EL (2015), Huttlin EL (2017)	7
ATR	6	RAD9A	1	affinity chromatography technology	Pabla N (2008)	1
HUS1	1	POLE	10	genetic interference	Horlbeck MA (2018)	1
RFC1	1	RFC2	0	biochemical, biochemical, biochemical	Tomida J (2008), Havugimana PC (2012), Wan C (2015)	3
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
ATR	6	CHEK1	2	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, genetic interference	Kim ST (1999), Sun TP (2009), Zhao H (2001), Rocha S (2005), Choi JH (2007), Ha K (2011), Srivas R (2016)	7
ATM	9	H2AFX	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Tsai WB (2008), Tsai WB (2008), Dittmann K (2011), Pan MR (2011), Kim K (2012), Rezaeian AH (2017)	6
TOP2A	2	CHEK1	2	genetic interference	Srivas R (2016)	1
ATM	9	RFC1	1	biochemical	Wang Y (2000)	1
FOXO3	1	ATM	9	affinity chromatography technology, affinity chromatography technology, pull down	Tsai WB (2008), Tsai WB (2008), Tsai WB (2008)	3
ATR	6	H2AFX	1	imaging technique, enzymatic study	Ray A (2009), Kim K (2012)	2
RAD17	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2010), Zhang L (2010), Zhang L (2010)	3
CHEK2	2	RFC1	1	genetic interference	Srivas R (2016)	1
RAD17	2	RFC5	2	pull down, affinity chromatography technology	Zou L (2003), Huttlin EL (2017)	2
RAD17	2	RFC3	0	pull down, affinity chromatography technology	Zou L (2003), Huttlin EL (2017)	2
POLE3	0	POLE	10	pull down, biochemical, biochemical, affinity chromatography technology	Bermudez VP (2011), Havugimana PC (2012), Wan C (2015), Moiseeva TN (2016)	4
FOXO3	1	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Tsai WB (2008), Tsai WB (2008)	2
COPS7A	0	RAD17	2	affinity chromatography technology	Hein MY (2015)	1
RAD9A	1	HUS1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Dufault VM (2003), Volkmer E (1999), Volkmer E (1999), Griffith JD (2002), Hirai I (2002), Huttlin EL (2015), Huttlin EL (2017)	8
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
RAD9B	1	RAD1	0	affinity chromatography technology	Dufault VM (2003)	1
HUS1	1	RFC5	2	genetic interference	Horlbeck MA (2018)	1
ATM	9	RAD17	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Bao S (2001), Tsai WB (2008)	3
RFC4	1	RFC5	2	two hybrid, biochemical, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, affinity chromatography technology	Rual JF (2005), Cai J (1997), Cai J (1998), Ellison V (1998), Havugimana PC (2012), Uhlmann F (1997), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	9
RFC4	1	RAD1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATR	6	CHEK2	2	enzymatic study, enzymatic study, genetic interference	Olson E (2006), Matsuoka S (2000), Srivas R (2016)	3
RFC2	0	RFC3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ATR	6	HUS1	1	affinity chromatography technology	Pabla N (2008)	1
FOXO3	1	RAD17	2	affinity chromatography technology	Tsai WB (2008)	1
RFC2	0	PRKDC	12	biochemical	Kristensen AR (2012)	1
TOP1	1	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	5