PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZFYVE28	7	RAB4A	0	imaging technique	Mosesson Y (2009)	1
PRKCI	1	RAB4A	0	affinity chromatography technology	Imamura T (2003)	1
RAB2B	0	RAB5A	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB7A	0	RAB5A	0	two hybrid, biochemical, biochemical	Bucci C (1999), Havugimana PC (2012), Wan C (2015)	3
RAB7A	0	RAB4A	0	two hybrid	Bucci C (1999)	1
ZFYVE28	7	RAB7A	0	imaging technique	Mosesson Y (2009)	1
RAB4A	0	TP53	0	two hybrid	Stelzl U (2005)	1
IDH3A	0	RAB4A	0	two hybrid	Wang J (2011)	1
RAB4A	0	EXOC5	2	two hybrid	Rolland T (2014)	1
RAB4A	0	HACE1	2	pull down	Tang D (2011)	1
STX4	2	RAB5A	0	affinity chromatography technology	Perskvist N (2002)	1
RAB4A	0	RUFY1	4	affinity chromatography technology, pull down, pull down, two hybrid, pull down	Fouraux MA (2004), Fouraux MA (2004), Fouraux MA (2004), Yamamoto H (2010), Yamamoto H (2010)	5
TP53	0	PTTG1IP	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference	Read ML (2014), Read ML (2014), Read ML (2014), Read ML (2014), Read ML (2014), Xie L (2013)	6
RAB4A	0	RABEP2	0	two hybrid	Wang J (2011)	1
PIN1	0	TP53	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Wulf GM (2002), Wulf GM (2002), Zacchi P (2002), Zacchi P (2002), Vinayagam A (2011), Mantovani F (2007)	6
GDI1	1	RAB7A	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
GRIPAP1	0	RAB4A	0	two hybrid	Wang J (2011)	1
GDI2	1	RAB7A	0	biochemical	Wan C (2015)	1
CD2AP	0	RAB4A	0	two hybrid, pull down	Cormont M (2003), Cormont M (2003)	2
FGFR1	2	RAB2B	0	affinity chromatography technology	Vecchione A (2007)	1
FGFR1	2	RAB4A	0	affinity chromatography technology	Vecchione A (2007)	1
FGFR1	2	RAB7A	0	affinity chromatography technology	Vecchione A (2007)	1
RAB2B	0	GDI1	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	RUFY1	4	affinity chromatography technology, pull down, pull down	Fouraux MA (2004), Fouraux MA (2004), Fouraux MA (2004)	3
GDI1	1	GDI2	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	RAB7A	0	two hybrid	Daakour S (2016)	1
GRPR	0	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	RAB7A	0	affinity chromatography technology	Chen Y (2013)	1
RBSN	2	RAB4A	0	pull down, x-ray crystallography	Eathiraj S (2005), Eathiraj S (2005)	2
GDI2	1	RAB4A	0	pull down	Shisheva A (1999)	1
RAB4A	0	STX4	2	affinity chromatography technology, pull down	Li L (2001), Li L (2001)	2
BAG3	4	RAB4A	0	affinity chromatography technology	Chen Y (2013)	1
RBSN	2	RAB5A	0	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Nielsen E (2000), Nielsen E (2000), Schnatwinkel C (2004), Eathiraj S (2005), Mishra A (2010)	5
LAMP1	0	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB4A	0	PIN1	0	affinity chromatography technology	Gerez L (2000)	1
RAB4A	0	KIF3B	3	pull down, affinity chromatography technology	Imamura T (2003), Imamura T (2003)	2
RUFY1	4	RABEP1	4	biochemical	Fouraux MA (2004)	1
BAG3	4	RAB5A	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
RAB4A	0	RAB11FIP1	2	two hybrid, pull down	Lindsay AJ (2002), Lindsay AJ (2002)	2
RAB2B	0	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
EREG	0	RAB4A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLC22A9	5	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB4A	0	KCNA5	2	imaging technique	Zadeh AD (2008)	1
RABEP1	4	RAB4A	0	two hybrid, pull down, biochemical, pull down, pull down	Vitale G (1998), Vitale G (1998), Vitale G (1998), Christoforidis S (2000), Kaelin S (2015)	5
GDI2	1	RAB5A	0	pull down, affinity chromatography technology	Shisheva A (1999), Huttlin EL (2017)	2
FGFR1	2	RAB5A	0	affinity chromatography technology	Vecchione A (2007)	1
RAB5A	0	GDI1	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	KCNA5	2	imaging technique	Zadeh AD (2008)	1
RAB4A	0	RAB5A	0	biochemical	Vitale G (1998)	1
PTTG1IP	1	RAB4A	0	two hybrid	Wang J (2011)	1
RAB4A	0	DYNC1LI1	1	two hybrid	Bielli A (2001)	1
RABEP1	4	RABEP2	0	biochemical	Christoforidis S (2000)	1
RAB4A	0	RABGAP1	2	two hybrid	Wang J (2011)	1
RAB4A	0	VPS52	0	two hybrid	Rolland T (2014)	1
RABEP1	4	GRIPAP1	0	affinity chromatography technology	Boldt K (2016)	1
GDI1	1	RAB4A	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
BAG3	4	GDI2	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
BAG3	4	RAB2B	0	affinity chromatography technology	Chen Y (2013)	1
RAB5A	0	KIF3B	3	affinity chromatography technology	Imamura T (2003)	1
VPS52	0	RABEP2	0	two hybrid	Yu H (2011)	1
SCCPDH	2	RAB4A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRIG1	1	RAB4A	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	RABEP2	0	pull down	Christoforidis S (2000)	1
RAB4A	0	ZNF830	3	two hybrid	Wang J (2011)	1
CD2AP	0	RABEP2	0	biochemical	Kristensen AR (2012)	1
RABEP1	4	RAB5A	0	two hybrid, two hybrid, two hybrid, biochemical, pull down, pull down, pull down, affinity chromatography technology, pull down	Xiao GH (1997), Vitale G (1998), Vitale G (1998), Vitale G (1998), Stenmark H (1995), Valsdottir R (2001), Christoforidis S (2000), Schnatwinkel C (2004), Kaelin S (2015)	9
ZFYVE28	7	RAB5A	0	imaging technique	Mosesson Y (2009)	1