PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RAB3A	0	WDR45B	2	affinity chromatography technology	Huttlin EL (2015)	1
SLC15A1	0	RAB3B	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB3A	0	RABGGTA	1	affinity chromatography technology	Huttlin EL (2015)	1
RABIF	0	RAB3A	0	pull down, two hybrid	Burton JL (1997), Rolland T (2014)	2
DNAAF2	2	SNCA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BSN	9	RIMS1	6	affinity chromatography technology	Takao-Rikitsu E (2004)	1
DGUOK	1	APP	1	pull down	Olah J (2011)	1
RAB3A	0	RPH3A	7	x-ray crystallography, pull down	Ostermeier C (1999), Weber E (1996)	2
RAB3A	0	IBA57	0	affinity chromatography technology	Huttlin EL (2015)	1
DNAAF2	2	APP	1	pull down	Olah J (2011)	1
NUFIP1	0	RAB3B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	RAB3A	0	protein complementation assay	Deribe YL (2009)	1
RNF32	0	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ADRB2	0	RAB3A	0	protein complementation assay	Kittanakom S (2014)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
ARMC1	2	APP	1	pull down	Olah J (2011)	1
RAB3A	0	VWA5B2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
DNAAF2	2	RAB3A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUFIP1	0	SNCA	0	affinity chromatography technology	Huttlin EL (2015)	1
RAB3B	0	GDI1	1	pull down	Sidhu RS (2001)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
RAB3A	0	RAB33B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	AP1M2	2	affinity chromatography technology	Foerster S (2013)	1
RABGGTB	1	RAB3A	0	two hybrid	Johannes L (1996)	1
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
RABGGTB	1	RABGGTA	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
EGFR	5	MAST1	9	protein complementation assay	Deribe YL (2009)	1
HAX1	1	SNCA	0	affinity chromatography technology	Huttlin EL (2015)	1
WDR45B	2	APP	1	pull down	Olah J (2011)	1
GDI1	1	GDI2	1	affinity chromatography technology	Huttlin EL (2017)	1
AP1M2	2	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
DGUOK	1	RAB3A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAB3A	0	RANGRF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
RPH3A	7	RAB3B	0	pull down	Weber E (1996)	1
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
SYTL4	0	RAB3B	0	affinity chromatography technology	Vogel GF (2015)	1
RABGGTA	1	CHM	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB3A	0	SNCA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dalfo E (2004), Dalfo E (2005), Dalfo E (2005)	3
RAB3A	0	GDI2	1	affinity chromatography technology	Huttlin EL (2017)	1
A2M	8	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
RIMS1	6	RAB3A	0	pull down	Betz A (2001)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RABAC1	0	RAB3A	0	two hybrid	Martincic I (1997)	1
TGOLN2	1	RAB3B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BSN	9	RAB3A	0	affinity chromatography technology	Takao-Rikitsu E (2004)	1
RAB3A	0	MOCOS	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RABGGTA	1	CHML	2	affinity chromatography technology	Huttlin EL (2017)	1
CHM	1	RAB3A	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Cremers FP (1994), Pereira-Leal JB (2003), Huttlin EL (2015), Huttlin EL (2017)	4
SYTL4	0	RAB3A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fukuda M (2003), Kuroda TS (2002), Kuroda TS (2002), Yi Z (2002), Huttlin EL (2015), Huttlin EL (2017)	6
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
NUFIP1	0	RAB3A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
TGOLN2	1	RAB3A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
SNCA	0	RABAC1	0	pull down, affinity chromatography technology	Lee HJ (2011), Lee HJ (2011)	2
PSEN1	11	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
ARMC1	2	RAB3A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAB3A	0	GDI1	1	affinity chromatography technology	Huttlin EL (2017)	1
HAX1	1	RAB3A	0	affinity chromatography technology	Huttlin EL (2017)	1
ECSIT	3	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
SLC15A1	0	RAB3A	0	affinity chromatography technology	Huttlin EL (2017)	1
PSEN1	11	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
DGUOK	1	SNCA	0	affinity chromatography technology	Huttlin EL (2015)	1
CHML	2	RAB3A	0	pull down, affinity chromatography technology, affinity chromatography technology	Cremers FP (1994), Huttlin EL (2015), Huttlin EL (2017)	3
RAB3A	0	RAB3B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
SYTL5	2	RAB3A	0	pull down, affinity chromatography technology	Kuroda TS (2002), Kuroda TS (2002)	2
RAB3A	0	RAB3IP	0	two hybrid	Rolland T (2014)	1