PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ACTN2	2	ACTN4	4	biochemical	Havugimana PC (2012)	1
TRIM55	2	TCAP	0	two hybrid	Witt CC (2008)	1
PNKP	3	MYOZ1	1	two hybrid	Rual JF (2005)	1
ACTN1	5	ACTN4	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
FLNC	8	MYOZ1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Takada F (2001), Takada F (2001), Frey N (2002), Faulkner G (2000)	4
TRIM55	2	FLNC	8	two hybrid	Witt CC (2008)	1
ACTN2	2	MYOZ1	1	two hybrid, pull down	Faulkner G (2000), Faulkner G (2000)	2
PRKAA2	1	BRCA1	7	two hybrid, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014)	2
MAGEA11	1	MYOZ1	1	two hybrid	Rual JF (2005)	1
MYOZ1	1	TRIM63	0	two hybrid, two hybrid, pull down	Moriscot AS (2010), Witt CC (2008), Witt CC (2008)	3
MYOZ1	1	APP	1	pull down	Olah J (2011)	1
TRIM55	2	MYOZ1	1	two hybrid	Witt CC (2008)	1
ACTN1	5	MAGEA11	1	two hybrid	Rual JF (2005)	1
GRB2	2	PPP3CA	3	two hybrid	Vinayagam A (2011)	1
BRCA1	7	FLNC	8	affinity chromatography technology	Ertych N (2016)	1
TRIM63	0	FLNC	8	two hybrid	Witt CC (2008)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
MYOZ1	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
PRKAA2	1	MYOZ1	1	two hybrid	Moreno D (2009)	1
TRIM63	0	TCAP	0	two hybrid, two hybrid	Witt SH (2005), Witt CC (2008)	2
PPP3CA	3	MYOZ1	1	affinity chromatography technology	Frey N (2000)	1
MYOZ1	1	TCAP	0	affinity chromatography technology, pull down	Frey N (2002), Faulkner G (2000)	2
GRB2	2	MYOZ1	1	two hybrid	Grossmann A (2015)	1
MAGEA11	1	PNKP	3	two hybrid	Rual JF (2005)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1
ACTN1	5	MYOZ1	1	two hybrid	Rual JF (2005)	1
ACTN4	4	MYOZ1	1	two hybrid	Rual JF (2005)	1
ACTN1	5	ACTN2	2	biochemical	Havugimana PC (2012)	1
PNKP	3	APP	1	pull down	Olah J (2011)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
COPS5	0	MYOZ1	1	affinity chromatography technology	Bennett EJ (2010)	1