PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAGOHB	1	ZNF250	2	two hybrid	Rolland T (2014)	1
PRPF31	0	CCDC136	1	two hybrid	Rolland T (2014)	1
TRIM54	1	GMCL1	0	two hybrid	Rolland T (2014)	1
ZNF250	2	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
MTUS2	4	PRPF31	0	two hybrid	Rolland T (2014)	1
TFF1	0	ZNF250	2	two hybrid	Rolland T (2014)	1
ZNF250	2	TPM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF473	1	TRIM41	6	two hybrid	Rual JF (2005)	1
SSX2IP	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM23	3	CARD9	3	two hybrid	Rolland T (2014)	1
CEP44	2	TRIM41	6	two hybrid	Rolland T (2014)	1
TNNT1	0	CCDC85B	0	two hybrid	Rual JF (2005)	1
TNNT1	0	NINL	1	two hybrid	Rual JF (2005)	1
NINL	1	TPM2	2	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
CARD9	3	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF250	2	SSX2IP	0	two hybrid	Rolland T (2014)	1
CCDC85B	0	LDOC1	0	two hybrid	Rual JF (2005)	1
TRIM23	3	TRAF1	0	two hybrid	Rolland T (2014)	1
HOOK1	0	HOOK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008)	4
MTUS2	4	ZNF250	2	two hybrid	Rolland T (2014)	1
ZNF250	2	TRIM41	6	two hybrid	Rolland T (2014)	1
ZNF250	2	ZNF250	2	two hybrid	Rolland T (2014)	1
CEP44	2	DVL2	5	bioid	Gupta GD (2015)	1
HOOK2	0	ZNF250	2	two hybrid	Rual JF (2005)	1
TRIM41	6	FAM124A	3	two hybrid	Rolland T (2014)	1
NINL	1	ZNF250	2	two hybrid	Rual JF (2005)	1
MAGOHB	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
CARD9	3	LZTS2	4	two hybrid	Rolland T (2014)	1
MID2	1	PRPF31	0	two hybrid	Rolland T (2014)	1
MID2	1	GMCL1	0	two hybrid	Rolland T (2014)	1
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF165	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
ZNF250	2	PLEKHF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZNF165	1	ZNF250	2	two hybrid	Rual JF (2005)	1
HOOK1	0	ZNF250	2	two hybrid	Rual JF (2005)	1
PRPF31	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM28	1	ZNF460	4	affinity chromatography technology	Huttlin EL (2017)	1
PRPF31	0	CDCA7L	5	two hybrid	Rolland T (2014)	1
CCDC85B	0	CARD9	3	two hybrid	Rual JF (2005)	1
TRIM54	1	SSX2IP	0	two hybrid	Rolland T (2014)	1
TMCC2	1	ZNF250	2	two hybrid	Rolland T (2014)	1
PRPF31	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
MID2	1	MAGOHB	1	two hybrid	Rolland T (2014)	1
CCDC85B	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ZNF250	2	SYNE4	1	two hybrid	Rolland T (2014)	1
PRPF31	0	ZNF250	2	two hybrid	Rolland T (2014)	1
ZNF250	2	TRAF1	0	two hybrid	Yu H (2011)	1
TRIM27	2	BEGAIN	3	two hybrid	Rual JF (2005)	1
BEGAIN	3	ZNF250	2	two hybrid	Rual JF (2005)	1
HEXIM2	0	ZNF250	2	two hybrid	Yu H (2011)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
CCDC85B	0	ZNF250	2	two hybrid	Rual JF (2005)	1
ZNF165	1	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF250	2	CEP44	2	two hybrid	Rual JF (2005)	1
DVL2	5	ZNF165	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
ZNF175	3	ZNF250	2	two hybrid	Rolland T (2014)	1
TRIM23	3	ZNF250	2	two hybrid	Rual JF (2005)	1
ZNF165	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
TRIM27	2	CCDC102B	0	two hybrid	Rolland T (2014)	1
ZNF250	2	GNPTAB	6	two hybrid	Rolland T (2014)	1
ZNF250	2	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZNF165	1	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
ZNF165	1	CCDC85B	0	two hybrid	Rual JF (2005)	1
TRIM41	6	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZNF250	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	MAGOHB	1	two hybrid	Rolland T (2014)	1
TNNT1	0	ZNF250	2	two hybrid	Vinayagam A (2011)	1
LZTS2	4	SSX2IP	0	affinity chromatography technology	Huttlin EL (2017)	1
CDCA7L	5	ZNF250	2	two hybrid	Rolland T (2014)	1
TRIM27	2	PRPF31	0	two hybrid	Rolland T (2014)	1
CARD9	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF250	2	LZTS2	4	two hybrid	Rolland T (2014)	1
DVL2	5	ZNF250	2	two hybrid	Rual JF (2005)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
ZNF250	2	CCDC136	1	two hybrid	Rolland T (2014)	1
ZNF250	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF165	1	FAM124A	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZNF460	4	ZNF250	2	two hybrid	Rolland T (2014)	1
TNS2	3	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
DVL2	5	ZBTB8A	0	two hybrid	Rual JF (2005)	1
ZNF250	2	KRT40	0	two hybrid	Rolland T (2014)	1
SSX2IP	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
DVL2	5	MAGOHB	1	two hybrid	Yu H (2011)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
TNNT1	0	LDOC1	0	two hybrid	Rolland T (2014)	1
PLEKHF2	1	CEP44	2	two hybrid	Rolland T (2014)	1
MID2	1	ZNF250	2	two hybrid	Rolland T (2014)	1
ZNF250	2	TRIM28	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM54	1	CARD9	3	two hybrid	Rolland T (2014)	1
TRIM54	1	FAM124A	3	two hybrid	Rolland T (2014)	1
TRIM54	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
CARD9	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
ZNF250	2	CCDC102B	0	two hybrid	Rolland T (2014)	1
ZNF473	1	ZNF250	2	two hybrid	Rolland T (2014)	1
ZNF165	1	MID2	1	two hybrid	Rolland T (2014)	1
KRTAP4-12	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CDCA7L	5	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
DVL2	5	DPPA2	0	two hybrid	Rual JF (2005)	1
CDCA7L	5	CARD9	3	two hybrid	Rolland T (2014)	1
ZNF175	3	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
ZNF250	2	CARD9	3	two hybrid	Rolland T (2014)	1
GOLGA2	2	PRPF31	0	two hybrid	Rolland T (2014)	1
TNNT1	0	KRT40	0	two hybrid	Rolland T (2014)	1
SSX2IP	0	DVL2	5	bioid	Gupta GD (2015)	1
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
LDOC1	0	PRPF31	0	two hybrid	Rolland T (2014)	1
TNNT1	0	CCDC136	1	two hybrid	Rolland T (2014)	1
PLEKHF2	1	LDOC1	0	two hybrid	Venkatesan K (2009)	1
TMCC2	1	PRPF31	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	ZNF250	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PRPF31	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
TRIM54	1	ZNF250	2	two hybrid	Rolland T (2014)	1
ZC4H2	3	ZNF250	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TNS2	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
TRIM27	2	ZNF250	2	two hybrid	Rolland T (2014)	1
CDCA7L	5	SSX2IP	0	two hybrid	Rolland T (2014)	1
ZNF250	2	LTF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF250	2	FAM124A	3	two hybrid	Rolland T (2014)	1
LDOC1	0	ZNF250	2	two hybrid	Rual JF (2005)	1
TNS2	3	ZNF250	2	two hybrid	Rolland T (2014)	1
MAGOHB	1	KRT40	0	two hybrid	Rolland T (2014)	1
ZNF250	2	SPINT1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF250	2	DPPA2	0	two hybrid	Rual JF (2005)	1
ZNF250	2	CCDC155	2	two hybrid	Rolland T (2014)	1
ZNF250	2	GMCL1	0	two hybrid	Rolland T (2014)	1