PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PEX2	2	TLE1	6	two hybrid	Stelzl U (2005)	1
PEX5	2	PEX2	2	affinity chromatography technology	Okumoto K (2011)	1
PEX14	2	PEX2	2	biochemical	Bharti P (2011)	1
PEX2	2	APP	1	pull down	Olah J (2011)	1
PEX14	2	PEX10	0	biochemical	Bharti P (2011)	1
PEX2	2	PEX10	0	pull down	Okumoto K (2000)	1
PEX10	0	PEX5	2	pull down, affinity chromatography technology	Okumoto K (2000), Okumoto K (2011)	2
PEX14	2	PEX5	2	two hybrid, pull down, pull down, pull down, pull down, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical	Okumoto K (2000), Okumoto K (2000), Otera H (2002), Otera H (2002), Shimizu N (1999), Fransen M (2002), Fransen M (2002), Fransen M (2002), Will GK (1999), Will GK (1999), Will GK (1999), Okumoto K (2011), Bharti P (2011), Bharti P (2011)	14
PEX2	2	ERG28	0	two hybrid	Stelzl U (2005)	1