PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATR	6	RPA2	0	enzymatic study, affinity chromatography technology	Olson E (2006), Marechal A (2014)	2
DNAJC7	2	RAD1	0	affinity chromatography technology	Xiang SL (2001)	1
RAD9B	1	RAD17	2	affinity chromatography technology	Dufault VM (2003)	1
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
HUS1	1	MSH3	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD9A	1	COPS5	0	imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007)	5
RHNO1	1	HUS1	1	affinity chromatography technology	Cotta-Ramusino C (2011)	1
HUS1	1	COPS5	0	imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference	Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Horlbeck MA (2018)	6
RHNO1	1	RAD1	0	affinity chromatography technology	Cotta-Ramusino C (2011)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
ATRX	7	RPA1	0	affinity chromatography technology	Leung JW (2013)	1
RAD9B	1	HUS1	1	affinity chromatography technology	Dufault VM (2003)	1
RAD9A	1	MSH3	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
FEN1	1	RAD1	0	affinity chromatography technology, affinity chromatography technology	Friedrich-Heineken E (2005), Wang W (2004)	2
RAD9A	1	RAD17	2	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Bermudez VP (2003), Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Lindsey-Boltz LA (2001), Zhang L (2010)	7
PRKN	1	RAD1	0	two hybrid	Stelzl U (2005)	1
DNAJC7	2	HUS1	1	affinity chromatography technology	Xiang SL (2001)	1
RAD9A	1	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD1	0	RPA1	0	affinity chromatography technology, affinity chromatography technology	Wu X (2005), Wu X (2005)	2
DNAJC7	2	RAD9A	1	affinity chromatography technology, pull down	Xiang SL (2001), Xiang SL (2001)	2
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
MSH2	4	MSH3	4	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, pull down	Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Palombo F (1996), Havugimana PC (2012), Owen BA (2009)	8
RPA2	0	RFC4	1	affinity chromatography technology	Marechal A (2014)	1
RAD9A	1	RAD1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Dufault VM (2003), Volkmer E (1999), Volkmer E (1999), Griffith JD (2002), Hirai I (2002), Hirai I (2002), Lindsey-Boltz LA (2001), Huttlin EL (2015), Huttlin EL (2017)	10
HUS1B	0	RAD1	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hang H (2002), Hang H (2002), Hang H (2002), Huttlin EL (2017)	4
RHNO1	1	RAD9A	1	affinity chromatography technology, affinity chromatography technology	Cotta-Ramusino C (2011), Cotta-Ramusino C (2011)	2
RPA1	0	RFC4	1	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
RAD17	2	HUS1	1	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Huttlin EL (2015), Huttlin EL (2017)	5
HUS1	1	RPA1	0	affinity chromatography technology, affinity chromatography technology	Wu X (2005), Wu X (2005)	2
MSH2	4	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2003), Wang Y (2003), Wang Y (2003), Wang Y (2003), Pabla N (2011), Pabla N (2011), Pabla N (2011)	7
ATR	6	RAD1	0	affinity chromatography technology	Pabla N (2008)	1
ATRX	7	RAD9A	1	affinity chromatography technology	Leung JW (2013)	1
FEN1	1	RAD9A	1	affinity chromatography technology	Friedrich-Heineken E (2005)	1
MSH3	4	RPA1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Marechal A (2014)	2
RAD17	2	RAD1	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2003), Bermudez VP (2003), Rauen M (2000), Bao S (2001), Bao S (2001)	5
RPA2	0	MSH3	4	affinity chromatography technology	Marechal A (2014)	1
HUS1	1	ZBTB14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MSH2	4	FEN1	1	biochemical	Wan C (2015)	1
RAD9A	1	MSH2	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD1	0	COPS5	0	imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007)	5
RAD1	0	ZBTB14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA2	0	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
MSH3	4	MSH6	2	biochemical	Havugimana PC (2012)	1
RAD1	0	RPA2	0	affinity chromatography technology	Wu X (2005)	1
ATRX	7	RAD1	0	affinity chromatography technology	Leung JW (2013)	1
RAD1	0	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
ATR	6	RAD17	2	unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kim ST (1999), Bao S (2001), Bao S (2001), Bomgarden RD (2004), Zhang L (2010)	5
RAD17	2	RFC4	1	pull down, affinity chromatography technology	Zou L (2003), Huttlin EL (2017)	2
RAD9A	1	RPA1	0	affinity chromatography technology	Wu X (2005)	1
HUS1	1	RFC4	1	genetic interference	Horlbeck MA (2018)	1
FEN1	1	HUS1	1	affinity chromatography technology	Friedrich-Heineken E (2005)	1
HUS1	1	MSH2	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD9A	1	RPA2	0	affinity chromatography technology	Wu X (2005)	1
HUS1B	0	ZBTB14	2	affinity chromatography technology	Huttlin EL (2017)	1
HUS1	1	MSH6	2	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD1	0	MSH3	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
HUS1	1	RAD1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Volkmer E (1999), Volkmer E (1999), Hang H (2002), Hirai I (2004), Warmerdam DO (2010), Huttlin EL (2015), Huttlin EL (2017)	7
ATR	6	RAD9A	1	affinity chromatography technology	Pabla N (2008)	1
RAD1	0	MSH2	4	affinity chromatography technology, far western blotting	Bai H (2010), Bai H (2010)	2
RAD9B	1	HUS1B	0	affinity chromatography technology	Dufault VM (2003)	1
HUS1	1	RPA2	0	affinity chromatography technology	Wu X (2005)	1
MSH6	2	FEN1	1	biochemical	Wan C (2015)	1
PRKN	1	RFC4	1	affinity chromatography technology	Zanon A (2013)	1
MSH6	2	ATR	6	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
RAD9A	1	HUS1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Dufault VM (2003), Volkmer E (1999), Volkmer E (1999), Griffith JD (2002), Hirai I (2002), Huttlin EL (2015), Huttlin EL (2017)	8
RAD9B	1	RAD1	0	affinity chromatography technology	Dufault VM (2003)	1
RAD9A	1	HUS1B	0	affinity chromatography technology, affinity chromatography technology	Dufault VM (2003), Huttlin EL (2017)	2
RFC4	1	RAD1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATR	6	HUS1	1	affinity chromatography technology	Pabla N (2008)	1