PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	IGF1R	5	affinity chromatography technology	Fei T (2017)	1
ERBB4	5	PTPRR	3	two hybrid	Yao Z (2017)	1
NTRK1	1	EPHA2	3	affinity chromatography technology	Emdal KB (2015)	1
SNX6	1	EGFR	5	affinity chromatography technology	Parks WT (2001)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
NTRK1	1	PTPRR	3	affinity chromatography technology, two hybrid	Emdal KB (2015), Yao Z (2017)	2
MAPK3	4	DHPS	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Corominas R (2014), So J (2015), Hein MY (2015)	4
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
FGFR2	6	PTPRR	3	two hybrid	Yao Z (2017)	1
ERBB3	3	PTPRR	3	two hybrid	Yao Z (2017)	1
HNRNPL	3	ROR2	0	affinity chromatography technology	Fei T (2017)	1
RYK	1	PTPRR	3	two hybrid	Yao Z (2017)	1
RET	3	PTPRR	3	two hybrid	Yao Z (2017)	1
MAPK11	1	MAPKAPK3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
KDR	4	PTPRR	3	two hybrid	Yao Z (2017)	1
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
RET	3	MAPK1	1	imaging technique	Chen TC (2014)	1
MAPKAPK3	0	MAPK14	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Tanoue T (2001), Tanoue T (2001), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Vogl T (2004), Huttlin EL (2017)	10
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
PTPRR	3	155100	0	affinity chromatography technology	Li X (2016)	1
HNRNPL	3	PTK7	8	affinity chromatography technology	Fei T (2017)	1
FGFR4	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	DNAJC13	5	affinity chromatography technology	Yao Z (2017)	1
MAPK3	4	RET	3	imaging technique	Chen TC (2014)	1
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
IGF1R	5	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTPRR	3	DNAJC13	5	bioid	St-Denis N (2016)	1
NTRK1	1	ALDH18A1	6	affinity chromatography technology	Emdal KB (2015)	1
PTPRR	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
ERBB2	6	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
PTPRR	3	MAPK7	1	affinity chromatography technology, pull down	Buschbeck M (2002), Buschbeck M (2002)	2
PTPRR	3	ALDH18A1	6	affinity chromatography technology	St-Denis N (2016)	1
NTRK1	1	DNAJC13	5	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
PTPRR	3	TBC1D5	0	bioid	St-Denis N (2016)	1
HNRNPL	3	DNAJC13	5	affinity chromatography technology	Fei T (2017)	1
EPHA2	3	PTPRR	3	two hybrid	Yao Z (2017)	1
NTRK1	1	IGF1R	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	MAPK7	1	affinity chromatography technology	Emdal KB (2015)	1
LMTK2	8	PTPRR	3	two hybrid	Yao Z (2017)	1
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
PTPRR	3	HSPA4L	1	affinity chromatography technology	Li X (2016)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
FGFR4	6	PTPRR	3	two hybrid	Yao Z (2017)	1
NTRK1	1	CBS	0	affinity chromatography technology	Emdal KB (2015)	1
PTPRR	3	TRIM11	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
PTPRR	3	MAPK1IP1L	0	affinity chromatography technology	Li X (2016)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
CEP290	5	PTPRR	3	affinity chromatography technology	Gupta GD (2015)	1
MAPK1	1	INSR	9	affinity chromatography technology	Lin YL (2000)	1
RYK	1	MAPK1	1	affinity chromatography technology	Berndt JD (2011)	1
PTPRR	3	SNX6	1	bioid	St-Denis N (2016)	1
INSR	9	PTPRR	3	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
AATK	6	PTPRR	3	two hybrid	Yao Z (2017)	1
ROR1	2	PTPRR	3	two hybrid	Yao Z (2017)	1
RYK	1	PTK7	8	affinity chromatography technology	Berndt JD (2011)	1
NTRK1	1	TBC1D5	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PTK7	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
MAPK14	0	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NTRK1	1	WASHC5	7	affinity chromatography technology	Emdal KB (2015)	1
MAPK3	4	TEK	2	affinity chromatography technology	Varjosalo M (2013)	1
PTPRR	3	MAD2L1BP	0	affinity chromatography technology	Li X (2016)	1
MST1R	4	PTPRR	3	two hybrid	Yao Z (2017)	1
EGFR	5	RET	3	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Bhinge K (2017), Bhinge K (2017)	4
EGFR	5	PTPRR	3	two hybrid	Yao Z (2017)	1
ERBB2	6	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	EPHA2	3	affinity chromatography technology	Tong J (2014)	1
ROR2	0	PTPRR	3	two hybrid	Yao Z (2017)	1
CEP290	5	PNMA2	0	affinity chromatography technology	Gupta GD (2015)	1
HNRNPL	3	INSR	9	affinity chromatography technology	Fei T (2017)	1
PTPRR	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
NTRK1	1	RET	3	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	TBC1D5	0	affinity chromatography technology	Fei T (2017)	1
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
ERBB2	6	PTPRR	3	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
TEK	2	PTPRR	3	two hybrid	Yao Z (2017)	1
PTPRR	3	WASHC5	7	bioid	St-Denis N (2016)	1
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
NTRK1	1	HSPA4L	1	affinity chromatography technology	Emdal KB (2015)	1
IGF1R	5	PTPRR	3	two hybrid	Yao Z (2017)	1
HNRNPL	3	PTPRR	3	affinity chromatography technology	Fei T (2017)	1
KDR	4	MAPK1	1	enzymatic study	Mamluk R (2010)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
HNRNPL	3	ERBB2	6	affinity chromatography technology	Fei T (2017)	1
PTK7	8	PTPRR	3	two hybrid	Yao Z (2017)	1
PTPRR	3	DHPS	3	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
SNX6	1	INSR	9	affinity chromatography technology	Parks WT (2001)	1
RYK	1	MAPK3	4	affinity chromatography technology	Berndt JD (2011)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
MAPK14	0	EPHA2	3	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTPRR	3	CBS	0	affinity chromatography technology	Li X (2016)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
PTPRR	3	PNMA2	0	affinity chromatography technology, bioid	St-Denis N (2016), St-Denis N (2016)	2
NTRK1	1	ROR2	0	affinity chromatography technology	Emdal KB (2015)	1
MAPK3	4	INSR	9	affinity chromatography technology	Lin YL (2000)	1
PTPRR	3	PTPRR	3	affinity chromatography technology	Li X (2016)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4