PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GHR	1	PTPRH	0	pull down, far western blotting	Pasquali C (2003), Pasquali C (2003)	2
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
KRTAP10-8	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
EGFR	5	PTPRH	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Yao Z (2017), Yao Z (2017), Yao Z (2017)	3
PTPRH	0	BCAR1	6	pull down	Noguchi T (2001)	1
ERBB2	6	ILKAP	2	two hybrid	Yao Z (2017)	1
PTPRH	0	LIG3	6	affinity chromatography technology	Yadav L (2017)	1
MLH1	6	PTPRH	0	two hybrid	Brieger A (2010)	1
EGFR	5	ILKAP	2	two hybrid	Yao Z (2017)	1
PTPRH	0	EXOC3	2	bioid	St-Denis N (2016)	1
PTPRH	0	PXN	1	pull down	Noguchi T (2001)	1
ERBB4	5	ILKAP	2	two hybrid	Yao Z (2017)	1
PTPRH	0	ARL13B	0	bioid	St-Denis N (2016)	1
ERBB4	5	PTPRH	0	two hybrid	Yao Z (2017)	1
PTPRH	0	RAB11FIP1	2	bioid	St-Denis N (2016)	1
PTPRH	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
PTPRH	0	RAB11FIP5	1	bioid	St-Denis N (2016)	1
ERBB2	6	PTPRH	0	affinity chromatography technology	Yao Z (2017)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
PTPRH	0	MCRIP1	0	affinity chromatography technology	Yadav L (2017)	1
PTPRH	0	C1orf226	1	bioid	St-Denis N (2016)	1
PTPRH	0	LRP6	3	bioid	St-Denis N (2016)	1
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
PTPRH	0	CORO1C	2	affinity chromatography technology	Yadav L (2017)	1
PTPRH	0	NOS1AP	0	bioid	St-Denis N (2016)	1
PTPRH	0	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
DHPS	3	PTPRH	0	two hybrid	Rolland T (2014)	1
BCAR1	6	ERBB2	6	affinity chromatography technology	Bisaro B (2016)	1
PTPRH	0	ILKAP	2	affinity chromatography technology	Yadav L (2017)	1
MLH1	6	EXOC3	2	two hybrid	Brieger A (2010)	1
ERBB3	3	ILKAP	2	two hybrid	Yao Z (2017)	1
ERBB3	3	PTPRH	0	two hybrid	Yao Z (2017)	1
PTPRH	0	RALGAPA1	12	bioid	St-Denis N (2016)	1
BCAR1	6	PXN	1	affinity chromatography technology, affinity chromatography technology	Salgia R (1996), Chellaiah MA (2001)	2
PTPRH	0	RALGAPB	9	bioid	St-Denis N (2016)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
EGFR	5	EXOC3	2	affinity chromatography technology	Foerster S (2013)	1
PTPRH	0	RICTOR	4	bioid	St-Denis N (2016)	1
PTPRH	0	NBEA	15	bioid	St-Denis N (2016)	1
EGFR	5	LANCL1	0	affinity chromatography technology	Tong J (2014)	1
PTPRH	0	LANCL1	0	affinity chromatography technology	Yadav L (2017)	1
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4