PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPRC	1	PLK3	0	affinity chromatography technology	Xie S (2001)	1
PTPRC	1	CD79B	0	affinity chromatography technology	Brown VK (1994)	1
PTPRC	1	CD8A	0	fluorescent resonance energy transfe	Mittler RS (1991)	1
PTPRC	1	LCK	0	affinity chromatography technology, pull down, affinity chromatography technology	Koretzky GA (1993), Ng DH (1996), Jury EC (2004)	3
PTPRC	1	PRKCSH	2	affinity chromatography technology	Arendt CW (1997)	1
CD44	1	LCK	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Taher TE (1996), Taher TE (1996), Ilangumaran S (1998), Ilangumaran S (1998)	4
CD1D	1	PTPRC	1	affinity chromatography technology	Campbell NA (1999)	1
PTPRC	1	PTPRCAP	0	pull down	Bruyns E (1995)	1
CD2	2	LGALS1	1	affinity chromatography technology	Walzel H (2000)	1
LYN	2	SKAP1	0	pull down	Marie-Cardine A (1997)	1
CD2	2	PTPRC	1	pull down	Schraven B (1990)	1
SKAP1	0	PTPRC	1	two hybrid, affinity chromatography technology	Wu L (2002), Wu L (2002)	2
LCK	0	SKAP1	0	pull down, affinity chromatography technology	Marie-Cardine A (1997), Marie-Cardine A (1999)	2
CD44	1	PTPRC	1	biochemical	Ilangumaran S (1998)	1
PTPRC	1	PAEP	1	imaging technique	Rachmilewitz J (2003)	1
CD2	2	LCK	0	affinity chromatography technology, pull down	Bell GM (1996), Bell GM (1996)	2
CD44	1	LGALS1	1	affinity chromatography technology	Huttlin EL (2017)	1
PTPRC	1	GANAB	8	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Arendt CW (1997), Arendt CW (1997), Baldwin TA (2000), Baldwin TA (2001), Baldwin TA (2001)	5
RNF11	0	PTPRC	1	two hybrid	Colland F (2004)	1
LGALS1	1	PTPRC	1	affinity chromatography technology	Pace KE (1999)	1
PTPRC	1	CD79A	2	affinity chromatography technology	Brown VK (1994)	1
CD4	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Hawash IY (2002), Foti M (2002), Bernhard OK (2004), Loewenberg M (2006), Py B (2007)	5
GANAB	8	PRKCSH	2	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
PTPRC	1	LYN	2	affinity chromatography technology, pull down	Brown VK (1994), Brown VK (1994)	2
LGALS1	1	CD4	1	affinity chromatography technology	Pace KE (1999)	1
U2AF2	7	GANAB	8	affinity chromatography technology	Whisenant TC (2015)	1
CD79A	2	CD79B	0	affinity chromatography technology, pull down	Schamel WW (2003), Pao LI (1998)	2
FBXO6	0	GANAB	8	affinity chromatography technology	Liu B (2012)	1
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
UHRF2	1	LYN	2	far western blotting	Mori T (2011)	1
SEMA4D	1	PTPRC	1	affinity chromatography technology	Herold C (1996)	1
PTPRC	1	CD4	1	fluorescent resonance energy transfe	Mittler RS (1991)	1
UHRF2	1	PTPRC	1	far western blotting	Mori T (2011)	1
LYN	2	CD22	3	enzymatic study, affinity chromatography technology	Poe JC (2000), Greer SF (1999)	2
U2AF2	7	LGALS1	1	affinity chromatography technology	Whisenant TC (2015)	1
PTPRC	1	CD247	1	pull down	Furukawa T (1994)	1
SLAMF1	2	LGALS1	1	affinity chromatography technology	Huttlin EL (2015)	1
U2AF2	7	PTPRC	1	affinity chromatography technology	Whisenant TC (2015)	1
UHRF2	1	LCK	0	far western blotting	Mori T (2011)	1
SLAMF1	2	PTPRC	1	affinity chromatography technology	Mikhalap SV (1999)	1
FBXO6	0	PTPRC	1	affinity chromatography technology	Liu B (2012)	1
CD22	3	PTPRC	1	affinity chromatography technology	Greer SF (1999)	1