PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NRCAM	1	PTPRB	4	pull down	Sakurai T (1997)	1
HNRNPL	3	VEGFA	3	affinity chromatography technology	Yao P (2013)	1
PTPRB	4	MAGI3	1	two hybrid, affinity chromatography technology, pull down	Adamsky K (2003), Adamsky K (2003), Adamsky K (2003)	3
NRCAM	1	MAGI3	1	two hybrid	Nakayama M (2002)	1
PTPRB	4	GOPC	5	bioid	St-Denis N (2016)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
VEGFA	3	PTPRB	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Koutsioumpa M (2015), Koutsioumpa M (2015), Koutsioumpa M (2015)	3
PTPRB	4	PTPRG	4	bioid	St-Denis N (2016)	1
PTPRB	4	EGFR	5	enzymatic study, two hybrid	Crossland S (1996), Yao Z (2017)	2
GHR	1	PTPRB	4	pull down	Pasquali C (2003)	1
HNRNPL	3	PTPRB	4	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	MAGI3	1	affinity chromatography technology	Fei T (2017)	1
PTPRB	4	RABEP2	0	bioid	St-Denis N (2016)	1
PTPRB	4	CDH5	2	affinity chromatography technology, enzymatic study	Nawroth R (2002), Nawroth R (2002)	2
HNRNPL	3	PTPRG	4	affinity chromatography technology	Fei T (2017)	1
PTPRB	4	PTN	0	imaging technique	Koutsioumpa M (2015)	1
EGFR	5	CDH5	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CNTN1	4	PTPRB	4	pull down, pull down	Sakurai T (1997), Peles E (1995)	2