PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KRT15	2	CCNB1IP1	0	two hybrid	Rolland T (2014)	1
CCNB1	3	KEAP1	0	affinity chromatography technology	Hein MY (2015)	1
CCNB1IP1	0	UBE2L3	1	two hybrid, pull down	Toby GG (2003), Toby GG (2003)	2
KEAP1	0	CCNB1IP1	0	two hybrid	Rolland T (2014)	1
PRKAA2	1	CCNB1IP1	0	two hybrid	Rolland T (2014)	1
BAG6	2	CCNB1IP1	0	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
CDK1	0	HIST1H1D	1	enzymatic study	Wei Y (2011)	1
CCNB1IP1	0	CCNB1IP1	0	two hybrid, enzymatic study, two hybrid	Rual JF (2005), Toby GG (2003), Rolland T (2014)	3
CDK1	0	CCNB1IP1	0	enzymatic study	Toby GG (2003)	1
EPM2AIP1	1	CCNB1IP1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
APP	1	KEAP1	0	affinity chromatography technology	Huttlin EL (2017)	1
NF2	1	CDK1	0	affinity chromatography technology	Zhou L (2015)	1
CCNB1IP1	0	HIST1H1D	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
CCNB1IP1	0	APP	1	pull down	Olah J (2011)	1
CCNB1IP1	0	CCNB1	3	two hybrid	Toby GG (2003)	1
CCNB1IP1	0	NF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Groenholm M (2006), Groenholm M (2006), Groenholm M (2006)	3