PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PCNA	0	POLD2	2	pull down, pull down, far western blotting, biochemical, affinity chromatography technology, affinity chromatography technology	Lu X (2002), Lu X (2002), Lu X (2002), Shikata K (2001), Cazzalini O (2014), Hein MY (2015)	6
RNF8	2	POLD4	0	enzymatic study	Zhang S (2013)	1
POLD3	0	POLD2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Pohler JR (2005), Shikata K (2001), Huttlin EL (2017)	3
POLD4	0	PCNA	0	pull down, far western blotting, pull down	Li H (2006), Li H (2006), Terai K (2013)	3
POLD4	0	POLE	10	pull down	Bermudez VP (2011)	1
SPRTN	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
POLD4	0	POLD1	5	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Hein MY (2015)	3
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
POLD3	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Shikata K (2001), Hein MY (2015)	2
POLE2	2	POLE	10	biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bermudez VP (2011), Bermudez VP (2011), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Moiseeva TN (2016)	7
SPRTN	0	POLD4	0	affinity chromatography technology	Kim MS (2013)	1
DTL	0	POLD4	0	enzymatic study	Terai K (2013)	1
SPRTN	0	POLD3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ghosal G (2012), Ghosal G (2012), Kim MS (2013), Kim MS (2013), Kim MS (2013)	5
PCNA	0	POLE	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Ohta S (2002), Ogi T (2010), Han J (2014), Wan C (2015), Boehm EM (2016)	5
POLD4	0	POLD3	0	pull down	Li H (2006)	1
POLD3	0	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, unspecified method, two hybrid, far western blotting, fluorescent resonance energy transfe, affinity chromatography technology	Ducoux M (2001), Ohta S (2002), Pohler JR (2005), Shikata K (2001), Shikata K (2001), Bruning JB (2004), Plosky BS (2006), Li H (2006), Nicolae CM (2014), Hein MY (2015)	10
POLE2	2	POLD4	0	biochemical	Bermudez VP (2011)	1
POLD2	2	POLD1	5	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Li H (2006), Li H (2006), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
POLD4	0	POLD2	2	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Huttlin EL (2017)	3
SPRTN	0	POLD2	2	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
RNF8	2	PCNA	0	enzymatic study, affinity chromatography technology, enzymatic study	Zhang S (2008), Zhang S (2008), Mattiroli F (2012)	3
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16