PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MARK4	6	MTCL1	8	affinity chromatography technology	Brajenovic M (2004)	1
TRIM25	5	HSPA4	3	affinity chromatography technology	Choudhury NR (2017)	1
TUBA1A	13	TUBB	3	biochemical, biochemical, pull down	Havugimana PC (2012), Kristensen AR (2012), Wang W (2014)	3
MARK4	6	RPIA	0	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	MARK4	6	enzymatic study	Persaud A (2009)	1
MARK4	6	DOCK7	3	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	ARHGEF2	4	affinity chromatography technology	Brajenovic M (2004)	1
YWHAH	0	CYFIP1	2	affinity chromatography technology	Brajenovic M (2004)	1
STK11	2	TUBA1A	13	two hybrid	Arroyo R (2015)	1
USP7	14	DOCK7	3	affinity chromatography technology	Sowa ME (2009)	1
MARK4	6	RNF41	2	affinity chromatography technology	Brajenovic M (2004)	1
YWHAH	0	DOCK7	3	affinity chromatography technology	Brajenovic M (2004)	1
PARD6A	0	MARK4	6	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	ACTA1	1	affinity chromatography technology	Trinczek B (2004)	1
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
PRKAA1	2	HSPA4	3	affinity chromatography technology	Al-Hakim AK (2005)	1
USP21	2	MARK4	6	affinity chromatography technology	Sowa ME (2009)	1
TRIM25	5	MARK4	6	affinity chromatography technology	Choudhury NR (2017)	1
STK11	2	PRKAA1	2	two hybrid, enzymatic study	Upadhyay S (2006), Upadhyay S (2006)	2
RPTOR	4	HSPA4	3	affinity chromatography technology	Jacinto E (2006)	1
PRKAA1	2	KRT40	0	two hybrid	Rolland T (2014)	1
PRKAA1	2	TUBA1A	13	affinity chromatography technology	Al-Hakim AK (2005)	1
YWHAH	0	ARHGEF2	4	affinity chromatography technology	Brajenovic M (2004)	1
MYO18A	7	MYH9	19	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
YWHAH	0	MARK4	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Brajenovic M (2004), Brajenovic M (2004)	4
PRNP	4	MARK4	6	pull down	Satoh J (2009)	1
PPP2CB	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Fogeron ML (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
YWHAH	0	HNRNPK	4	biochemical	Kristensen AR (2012)	1
STK11	2	MARK2	6	enzymatic study	Jaleel M (2006)	1
MARK4	6	KCTD20	2	affinity chromatography technology	Brajenovic M (2004)	1
SMARCA4	19	MYO18A	7	biochemical	Wan C (2015)	1
MAP2	7	NEDD4	2	affinity chromatography technology	Persaud A (2009)	1
TUBG1	2	HSPA4	3	biochemical	Wigley WC (1999)	1
KRT31	0	MARK4	6	two hybrid	Rolland T (2014)	1
PTBP1	2	MARK4	6	unspecified method	Fontana L (2015)	1
MARK4	6	RPTOR	4	enzymatic study	Li L (2013)	1
MANSC1	4	MARK4	6	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	PTBP1	2	affinity chromatography technology	Choudhury NR (2017)	1
USP9X	15	RPTOR	4	affinity chromatography technology	Agrawal P (2012)	1
PNMA1	0	PRKCI	1	affinity chromatography technology	Brajenovic M (2004)	1
PARD6A	0	CDC42	3	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Joberty G (2000), Qiu RG (2000), Qiu RG (2000), Noda Y (2001), Noda Y (2001), Brajenovic M (2004)	6
USP21	2	USP7	14	enzymatic study	Loch CM (2012)	1
YWHAH	0	PARD6A	0	affinity chromatography technology	Brajenovic M (2004)	1
CDC42	3	MYH10	9	affinity chromatography technology	Hein MY (2015)	1
YWHAH	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
MARK4	6	ODF2	1	imaging technique, affinity chromatography technology, enzymatic study	Kuhns S (2013), Kuhns S (2013), Kuhns S (2013)	3
HGS	5	KRT40	0	two hybrid	Rolland T (2014)	1
HNRNPK	4	MARK4	6	two hybrid	Rolland T (2014)	1
MARK4	6	MAPT	1	enzymatic study, fluorescent resonance energy transfe	Trinczek B (2004), Gu GJ (2013)	2
USP7	14	MYH9	19	affinity chromatography technology	Bhattacharya S (2015)	1
TRIM25	5	CYFIP1	2	affinity chromatography technology	Choudhury NR (2017)	1
PRKAA1	2	RPTOR	4	enzymatic study	Gwinn DM (2008)	1
TUBA1A	13	MAP2	7	affinity chromatography technology, pull down	Cerecedo D (2008), Nakamura A (1989)	2
MARK2	6	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Suzuki A (2004)	2
YWHAH	0	CYFIP2	7	affinity chromatography technology	Brajenovic M (2004)	1
MARK2	6	MARK4	6	affinity chromatography technology	Sowa ME (2009)	1
MARK4	6	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
PPP2R1A	8	SOGA1	1	affinity chromatography technology	Hein MY (2015)	1
PRKCI	1	MARK4	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Brajenovic M (2004), Brajenovic M (2004), Naz F (2015)	3
MARK4	6	TUBA1A	13	affinity chromatography technology	Trinczek B (2004)	1
MARK4	6	PNMA1	0	affinity chromatography technology	Brajenovic M (2004)	1
MYH10	9	MYH9	19	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
TRIM25	5	RPTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
TUBG1	2	TUBB	3	affinity chromatography technology	Fogeron ML (2013)	1
MARK2	6	PPP2R1A	8	affinity chromatography technology	Hein MY (2015)	1
PPP2CB	1	ARHGEF2	4	affinity chromatography technology	St-Denis N (2016)	1
MARK2	6	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Brajenovic M (2004), Brajenovic M (2004), Brajenovic M (2004)	4
MARK4	6	CYFIP1	2	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	PPP2R1A	8	affinity chromatography technology	Brajenovic M (2004)	1
STK11	2	MARK4	6	affinity chromatography technology	Brajenovic M (2004)	1
HNRNPK	4	HSPA4	3	biochemical	Havugimana PC (2012)	1
USP21	2	MAP4	8	affinity chromatography technology	Urbe S (2012)	1
MYH9	19	DOCK7	3	affinity chromatography technology	Hein MY (2015)	1
PTBP1	2	HNRNPK	4	two hybrid, two hybrid, pull down, pull down, biochemical, biochemical	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000), Havugimana PC (2012), Wan C (2015)	6
TUBA1A	13	MAPT	1	affinity chromatography technology	Seiberlich V (2012)	1
MTUS2	4	MARK4	6	two hybrid	Rolland T (2014)	1
PSMC3	0	MARK4	6	affinity chromatography technology	Huttlin EL (2017)	1
MARK2	6	SOGA1	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	SOGA1	1	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	PPP2CB	1	affinity chromatography technology	Brajenovic M (2004)	1
USP21	2	PRKCI	1	affinity chromatography technology	Sowa ME (2009)	1
NEDD4	2	HNRNPK	4	pull down	Ingham RJ (2005)	1
PRKAA1	2	MARK2	6	affinity chromatography technology	Al-Hakim AK (2005)	1
MYH9	19	ACTA1	1	affinity chromatography technology	Hein MY (2015)	1
MARK4	6	MYBBP1A	8	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	SOGA1	1	affinity chromatography technology	Brajenovic M (2004)	1
TRIM25	5	NOTCH2NL	1	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	MYH10	9	affinity chromatography technology	Trinczek B (2004)	1
YWHAH	0	TUBG1	2	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	TUBG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trinczek B (2004), Trinczek B (2004), Brajenovic M (2004)	3
MARK4	6	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
KHDRBS3	0	MARK4	6	two hybrid	Rolland T (2014)	1
PPP2R1A	8	ARHGEF2	4	affinity chromatography technology	Hein MY (2015)	1
PARD6A	0	TUBG1	2	biochemical	Vadhvani M (2013)	1
MARK4	6	USP9X	15	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Al-Hakim AK (2008), Al-Hakim AK (2008), Al-Hakim AK (2008), Brajenovic M (2004)	4
KRT31	0	HGS	5	two hybrid	Rolland T (2014)	1
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
STK11	2	SMARCA4	19	pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Marignani PA (2001), Marignani PA (2001), Brajenovic M (2004), Ivanov AA (2017)	4
HNRNPK	4	KHDRBS3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Hegele A (2012), Hegele A (2012)	3
RNF41	2	MARK2	6	affinity chromatography technology, enzymatic study	Lewandowski KT (2013), Lewandowski KT (2013)	2
TRIM25	5	MTCL1	8	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R1A	8	MTCL1	8	affinity chromatography technology	Hein MY (2015)	1
MARK4	6	SMARCA4	19	affinity chromatography technology	Brajenovic M (2004)	1
MARK2	6	ARHGEF2	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Yoshimura Y (2011), Yamahashi Y (2011), Yoshimura Y (2011), Yoshimura Y (2011), Yoshimura Y (2011)	6
USP21	2	MARK2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Urbe S (2012), Urbe S (2012)	3
RNF41	2	MTCL1	8	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	USP9X	15	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PPP2CB	1	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	TUBB	3	affinity chromatography technology	Trinczek B (2004)	1
TRIM25	5	PRKCI	1	affinity chromatography technology	Choudhury NR (2017)	1
TUBG1	2	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
MARK4	6	CYFIP2	7	affinity chromatography technology	Brajenovic M (2004)	1
MARK4	6	MAP2	7	enzymatic study	Trinczek B (2004)	1
PARD6A	0	MARK2	6	affinity chromatography technology	Brajenovic M (2004)	1
TRIM25	5	PPP2R1A	8	affinity chromatography technology	Choudhury NR (2017)	1
PNMA1	0	PNMA2	0	affinity chromatography technology	Brajenovic M (2004)	1
MYO18A	7	ACTA1	1	affinity chromatography technology	Hein MY (2015)	1
PPP2CB	1	DOCK7	3	two hybrid	Vinayagam A (2011)	1
USP21	2	ARHGEF2	4	affinity chromatography technology	Urbe S (2012)	1
TRIM25	5	MYBBP1A	8	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	MYO18A	7	affinity chromatography technology	Brajenovic M (2004)	1
PARD6A	0	SMARCA4	19	affinity chromatography technology	Hein MY (2015)	1
PRKCI	1	PARD6A	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Brajenovic M (2004), Suzuki A (2001), Suzuki A (2001), Suzuki A (2001), Lamark T (2003), Lamark T (2003), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Rolland T (2014), Yu H (2011), Hein MY (2015)	13
TRIM25	5	SMARCA4	19	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	MAP4	8	enzymatic study	Trinczek B (2004)	1
HSPA4	3	PRNP	4	affinity chromatography technology	Wang GH (2011)	1
PPP2CB	1	MYH10	9	affinity chromatography technology	Glatter T (2009)	1
MARK4	6	USP7	14	affinity chromatography technology	Brajenovic M (2004)	1
HGS	5	MARK4	6	pull down	Pridgeon JW (2009)	1
HSPA4	3	TUBB	3	biochemical	Wan C (2015)	1
TRIM25	5	MYH10	9	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4	2	MARK2	6	enzymatic study	Persaud A (2009)	1
MARK4	6	MYH9	19	affinity chromatography technology	Trinczek B (2004)	1
RNF41	2	SOGA1	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	MYH9	19	affinity chromatography technology	Choudhury NR (2017)	1
PRKAA1	2	MTUS2	4	two hybrid	Rolland T (2014)	1
PRKAA1	2	MARK4	6	affinity chromatography technology	Al-Hakim AK (2005)	1
MAPT	1	HSPA4	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Petrucelli L (2004), Kawakami F (2011), Jinwal UK (2012), Jinwal UK (2012), Jinwal UK (2012)	5
MARK4	6	CDC42	3	affinity chromatography technology	Brajenovic M (2004)	1
USP21	2	KRT40	0	two hybrid	Rolland T (2014)	1
MARK4	6	HSPA4	3	affinity chromatography technology	Trinczek B (2004)	1
MARK2	6	MAPT	1	enzymatic study, x-ray crystallography	Schwalbe M (2013), Schwalbe M (2013)	2
MARK2	6	MTCL1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Hutchins JR (2010), Sato Y (2013), Sato Y (2013), Sato Y (2013), Sato Y (2013), Hein MY (2015)	7
HGS	5	HNRNPK	4	biochemical	Wan C (2015)	1
MANSC1	4	MARK2	6	affinity chromatography technology	Huttlin EL (2017)	1
HGS	5	TUBB	3	pull down	Pridgeon JW (2009)	1
TRIM25	5	KCTD20	2	affinity chromatography technology	Choudhury NR (2017)	1
MARK4	6	KRT40	0	two hybrid	Rolland T (2014)	1