PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ABL1	9	HUWE1	22	enzymatic study	Gu J (1994)	1
HDAC5	4	TRIM28	1	affinity chromatography technology	Greco TM (2011)	1
OBSL1	9	LMNB2	2	affinity chromatography technology	Hanson D (2014)	1
HDAC9	7	HDAC3	5	pull down, affinity chromatography technology	Petrie K (2003), Zhou X (2000)	2
ANKRA2	0	GTF3C5	4	affinity chromatography technology	Nie J (2015)	1
OBSL1	9	TRIM28	1	affinity chromatography technology	Hanson D (2014)	1
PRDX2	1	APP	1	pull down	Olah J (2011)	1
ANKRA2	0	TRIM28	1	affinity chromatography technology	Nie J (2015)	1
HUWE1	22	TRIM28	1	affinity chromatography technology	Thompson JW (2014)	1
ANKRA2	0	LMNB2	2	affinity chromatography technology	Nie J (2015)	1
ANKRA2	0	PRDX2	1	affinity chromatography technology	Nie J (2015)	1
ANKRA2	0	HUWE1	22	affinity chromatography technology	Nie J (2015)	1
HDAC5	4	ANKRA2	0	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology	Wang AH (2005), Xu C (2012), Nie J (2015), Nie J (2015)	4
ANKRA2	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Nie J (2015), Nie J (2015), Nie J (2015), Nie J (2015)	4
ANKRA2	0	RFX5	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Xu C (2012), Nie J (2015), Huttlin EL (2017)	3
LMNA	2	PHB2	1	affinity chromatography technology	Depreux FF (2015)	1
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
CCDC8	1	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
LMNA	2	TRIM28	1	bioid, affinity chromatography technology	Roux KJ (2012), Depreux FF (2015)	2
PHB2	1	HDAC5	4	pull down, affinity chromatography technology, affinity chromatography technology	Kurtev V (2004), Kurtev V (2004), Greco TM (2011)	3
HDAC5	4	CUL7	4	affinity chromatography technology	Nie J (2015)	1
TRIM28	1	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Neo SH (2015), Neo SH (2015), Neo SH (2015), Neo SH (2015)	4
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
CCDC8	1	GTF3C5	4	affinity chromatography technology	Hanson D (2014)	1
HDAC4	10	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ZNF462	11	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
ANKRA2	0	MPL	4	unspecified method	Xu C (2012)	1
ANKRA2	0	LMNA	2	affinity chromatography technology	Nie J (2015)	1
CUL7	4	APP	1	affinity chromatography technology	Hanson D (2014)	1
AHRR	5	ANKRA2	0	affinity chromatography technology	Oshima M (2007)	1
ANKRA2	0	CUL7	4	affinity chromatography technology, affinity chromatography technology	Nie J (2015), Nie J (2015)	2
CCDC8	1	CCAR2	9	affinity chromatography technology	Hanson D (2014)	1
AHRR	5	HDAC4	10	affinity chromatography technology	Oshima M (2007)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
RFXAP	0	HDAC4	10	affinity chromatography technology	Wang AH (2005)	1
ANKRA2	0	PHB2	1	affinity chromatography technology	Nie J (2015)	1
ANKRA2	0	RFX7	6	affinity chromatography technology, pull down	Nie J (2015), Nie J (2015)	2
HDAC3	5	PHB2	1	pull down	Kurtev V (2004)	1
HDAC9	7	CCAR2	9	affinity chromatography technology	Joshi P (2013)	1
CUL7	4	TRIM28	1	affinity chromatography technology	Hanson D (2014)	1
HDAC5	4	CCAR2	9	affinity chromatography technology	Greco TM (2011)	1
NEK6	2	CCAR2	9	affinity chromatography technology	Ewing RM (2007)	1
AHRR	5	HDAC5	4	affinity chromatography technology	Oshima M (2007)	1
HDAC9	7	ANKRA2	0	pull down	Wang AH (2005)	1
HDAC4	10	CUL7	4	affinity chromatography technology	Nie J (2015)	1
CDKN2A	1	ANKRA2	0	two hybrid	Daakour S (2016)	1
RFX5	0	HDAC4	10	affinity chromatography technology	Wang AH (2005)	1
HDAC3	5	TRIM28	1	affinity chromatography technology	Tsuruma R (2008)	1
ANKRA2	0	RFXAP	0	affinity chromatography technology	Nie J (2015)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
ANKRA2	0	SOGA1	1	affinity chromatography technology	Nie J (2015)	1
CUL7	4	LMNB2	2	affinity chromatography technology	Hanson D (2014)	1
ANKRA2	0	OBSL1	9	affinity chromatography technology	Nie J (2015)	1
HDAC5	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Zhang J (2002), Grozinger CM (2000), Greco TM (2011), Greco TM (2011)	6
HDAC4	10	ANKRA2	0	two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology	Wang AH (2005), Wang AH (2005), Xu C (2012), Rolland T (2014), Nie J (2015)	5
CDK4	2	APP	1	pull down	Olah J (2011)	1
HUWE1	22	PHB2	1	affinity chromatography technology	Thompson JW (2014)	1
ANKRA2	0	APP	1	pull down	Olah J (2011)	1
CCDC8	1	TRIM28	1	affinity chromatography technology	Hanson D (2014)	1
ANKRA2	0	ZNF462	11	affinity chromatography technology	Nie J (2015)	1
ANKRA2	0	CDK4	2	affinity chromatography technology	Nie J (2015)	1
RFX5	0	RFX7	6	affinity chromatography technology	Huttlin EL (2017)	1
ANKRA2	0	CCAR2	9	affinity chromatography technology	Nie J (2015)	1
CCDC8	1	FAM83B	0	affinity chromatography technology	Hanson D (2014)	1
ANKRA2	0	PDE3B	3	unspecified method	Xu C (2012)	1
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
LMNA	2	LMNB2	2	bioid, affinity chromatography technology, two hybrid	Roux KJ (2012), Huttlin EL (2015), Dittmer TA (2014)	3
CCDC8	1	SOGA1	1	affinity chromatography technology	Hanson D (2014)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
OBSL1	9	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
ANKRA2	0	FAM83B	0	affinity chromatography technology	Nie J (2015)	1
ANKRA2	0	LRP2	13	two hybrid, pull down, affinity chromatography technology, x-ray crystallography	Rader K (2000), Rader K (2000), Rader K (2000), Xu C (2012)	4
NEK6	2	ANKRA2	0	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
CCDC8	1	HUWE1	22	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	LMNA	2	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CCAR2	9	affinity chromatography technology	Hanson D (2014)	1
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
APP	1	RFX5	0	pull down	Virok DP (2011)	1
ANKRA2	0	HDAC3	5	x-ray crystallography	Xu C (2012)	1
ANKRA2	0	ABL1	9	unspecified method	Xu C (2012)	1
RFXAP	0	RFX5	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Durand B (1997), Hein MY (2015), Huttlin EL (2017)	3
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	LMNB2	2	affinity chromatography technology	Hanson D (2014)	1
HDAC9	7	HDAC4	10	pull down	Petrie K (2003)	1