PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD3	1	MCM3AP	6	two hybrid	Colland F (2004)	1
CDC25A	2	TRIB3	0	affinity chromatography technology	Sakai S (2010)	1
RFWD2	0	TRIB3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vitari AC (2011), Lu G (2014), Huttlin EL (2015), Huttlin EL (2017)	4
AKT1	1	SETDB1	3	two hybrid, pull down, affinity chromatography technology	Gao H (2007), Gao H (2007), Gao H (2007)	3
FN1	17	RPSA	2	affinity chromatography technology	Humphries JD (2009)	1
GATD1	1	APP	1	pull down	Olah J (2011)	1
FBXO7	1	TRIB3	0	enzymatic study	Teixeira FR (2016)	1
FN1	17	EEF1G	0	affinity chromatography technology	Humphries JD (2009)	1
COPS6	0	RBM4	1	affinity chromatography technology	Bennett EJ (2010)	1
TRIB3	0	LTBP4	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
TRIB3	0	HLA-B	0	two hybrid	Zhou Y (2008)	1
SMURF1	4	PRMT5	3	affinity chromatography technology	Xie Y (2013)	1
TRIB3	0	RBM4	1	two hybrid	Zhou Y (2008)	1
FN1	17	RBM4	1	affinity chromatography technology	Humphries JD (2009)	1
TRIB3	0	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TRIB3	0	PSMA3	1	two hybrid	Zhou Y (2008)	1
BCL6	6	SIAH1	2	two hybrid	Rolland T (2014)	1
TRIB3	0	GRN	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
AKT1	1	TRIB3	0	pull down, affinity chromatography technology, two hybrid	Du K (2003), Du K (2003), Du K (2003)	3
STK40	4	APP	1	pull down	Olah J (2011)	1
SMURF1	4	EEF1G	0	affinity chromatography technology	Xie Y (2013)	1
KAT5	1	APP	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down	Sumioka A (2005), Kinoshita A (2002), von Rotz RC (2004), von Rotz RC (2004), von Rotz RC (2004), Cao X (2004), Li Q (2004), Olah J (2011)	8
TRIB3	0	RIDA	0	two hybrid	Zhou Y (2008)	1
STK40	4	RFWD2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Huttlin EL (2015), Huttlin EL (2017), Durzynska I (2017), Durzynska I (2017), Durzynska I (2017)	5
SMAD3	1	CDC25A	2	affinity chromatography technology, two hybrid	Ray D (2005), Wang J (2011)	2
TRIB3	0	SMURF1	4	two hybrid, affinity chromatography technology	Chan MC (2007), Chan MC (2007)	2
RELA	1	PRMT5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei H (2013), Wei H (2013), Yang F (2015)	3
TRIB3	0	TIAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
TRIB3	0	APP	1	pull down	Olah J (2011)	1
RELA	1	SMAD3	1	two hybrid	Wang J (2011)	1
TRIB3	0	GDF9	2	two hybrid	Stelzl U (2005)	1
CDC25A	2	MCM3AP	6	two hybrid	Wang J (2011)	1
TRIB3	0	RELA	1	affinity chromatography technology, affinity chromatography technology	Wu M (2003), Wu M (2003)	2
DDIT3	1	TRIB3	0	affinity chromatography technology, pull down	Ohoka N (2007), Ohoka N (2007)	2
TRIB3	0	KAT5	1	two hybrid	Stelzl U (2005)	1
SQSTM1	0	TRIB3	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Hua F (2015), Hua F (2015), Hua F (2015), Hua F (2015), Hua F (2015)	5
TRIB3	0	RBM48	1	two hybrid	Stelzl U (2005)	1
FBXO7	1	ATF5	4	enzymatic study	Teixeira FR (2016)	1
TRIB3	0	RPSA	2	two hybrid	Zhou Y (2008)	1
SMAD3	1	APP	1	pull down	Olah J (2011)	1
TRIB3	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
BCL6	6	TRIB3	0	affinity chromatography technology	Miles RR (2005)	1
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
KAT5	1	RELA	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JW (2012), Kim JW (2012), Kim JW (2012)	3
BMPR2	1	TRIB3	0	affinity chromatography technology, two hybrid	Chan MC (2007), Chan MC (2007)	2
AKT1	1	EEF1G	0	two hybrid	Vinayagam A (2011)	1
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
ATF4	2	APP	1	pull down	Olah J (2011)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
TRIB3	0	EEF1G	0	two hybrid	Stelzl U (2005)	1
TRIB3	0	STK40	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIB3	0	ATF5	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
AKT1	1	APP	1	pull down	Olah J (2011)	1
BMPR2	1	GDF9	2	pull down	Vitt UA (2002)	1
SMAD3	1	SQSTM1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRIB3	0	MCM3AP	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
TRIB3	0	GIT1	10	two hybrid	Stelzl U (2005)	1
FBXO7	1	RPSA	2	affinity chromatography technology	Teixeira FR (2016)	1
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
TRIB3	0	COPS6	0	two hybrid	Stelzl U (2005)	1
RPGRIP1	6	TRIB3	0	two hybrid	Rolland T (2014)	1
TRIB3	0	CSNK2B	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
TRIB3	0	SIAH1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
STK40	4	COPS6	0	two hybrid	Stelzl U (2005)	1
FN1	17	PRMT5	3	affinity chromatography technology	Humphries JD (2009)	1
TRIB3	0	FN1	17	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
TRIB3	0	GATD1	1	affinity chromatography technology	Huttlin EL (2015)	1
FN1	17	CSNK2B	5	affinity chromatography technology	Humphries JD (2009)	1
SMAD3	1	TRIB3	0	affinity chromatography technology, affinity chromatography technology	Hua F (2011), Hua F (2011)	2
CDC25A	2	APP	1	pull down	Olah J (2011)	1
PSMA3	1	FBXO7	1	two hybrid, affinity chromatography technology	Rolland T (2014), Teixeira FR (2016)	2
SMAD3	1	AKT1	1	affinity chromatography technology, imaging technique	Song K (2006), Chen TC (2014)	2
TRIB3	0	ATF4	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bowers AJ (2003), Bowers AJ (2003), Zhou Y (2008), Zhou Y (2008), Zhou Y (2008), Rolland T (2014)	6