PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AURKA	1	NDC80	4	enzymatic study	Tien AC (2004)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
EP300	36	FOSL2	2	enzymatic study	Wang WM (2011)	1
CALCOCO1	2	TBC1D15	1	two hybrid	Rolland T (2014)	1
SMURF1	4	CALCOCO1	2	enzymatic study	Andrews PS (2010)	1
CALCOCO1	2	FAM161A	2	two hybrid	Rolland T (2014)	1
DUSP13	1	CALCOCO1	2	two hybrid	Rolland T (2014)	1
CRYBA2	1	CALCOCO1	2	two hybrid	Rual JF (2005)	1
FOSL2	2	CYTH3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TXLNB	0	CALCOCO1	2	affinity chromatography technology	Huttlin EL (2017)	1
FOSL1	0	CALCOCO1	2	two hybrid	Rual JF (2005)	1
NDC80	4	CALCOCO1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NEDD4	2	CALCOCO1	2	enzymatic study	Persaud A (2009)	1
FOSL1	0	EP300	36	affinity chromatography technology, enzymatic study	Crish JF (2008), Wang WM (2011)	2
MAFF	0	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GABARAPL2	0	CALCOCO1	2	two hybrid	Rolland T (2014)	1
CYTH3	1	CALCOCO1	2	two hybrid	Rual JF (2005)	1
ISOC1	2	CALCOCO1	2	two hybrid	Rolland T (2014)	1
AURKA	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RALBP1	2	CALCOCO1	2	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	SMURF1	4	affinity chromatography technology	Fei T (2017)	1
AURKA	1	CTNNB1	30	affinity chromatography technology	Hein MY (2015)	1
BFSP2	1	CALCOCO1	2	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO1	2	CEP19	0	two hybrid	Rolland T (2014)	1
HNRNPL	3	CALCOCO1	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	FOSL2	2	affinity chromatography technology	Fei T (2017)	1
CALCOCO1	2	CWF19L2	2	two hybrid	Rolland T (2014)	1
APTX	3	CALCOCO1	2	two hybrid	Lim J (2006)	1
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
CWF19L2	2	APP	1	pull down	Olah J (2011)	1
FAM161A	2	TXLNB	0	two hybrid	Rolland T (2014)	1
FOSL2	2	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBC1D15	1	TBC1D17	2	affinity chromatography technology	Huttlin EL (2017)	1
CA10	5	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RABGGTB	1	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TPM3	0	CALCOCO1	2	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO1	2	SH3GL3	1	two hybrid	Stelzl U (2005)	1
CALCOCO1	2	CTNNB1	30	genetic interference	Yang CK (2006)	1
GABARAPL2	0	NEDD4	2	affinity chromatography technology	Behrends C (2010)	1
KRT15	2	CALCOCO1	2	two hybrid	Rual JF (2005)	1
PCBD1	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
SRPK2	1	AURKA	1	enzymatic study	Varjosalo M (2013)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
CALCOCO1	2	APP	1	pull down	Olah J (2011)	1
GABARAPL2	0	APP	1	pull down	Olah J (2011)	1
SRPK2	1	APP	1	pull down	Olah J (2011)	1
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
CALCOCO1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JH (2006), Kim JH (2006), Yang CK (2006), Yang CK (2006)	4
AURKA	1	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
CALCOCO1	2	ARNT	1	pull down, x-ray crystallography	Partch CL (2009), Partch CL (2009)	2
PCBD1	0	CALCOCO1	2	two hybrid	Ravasi T (2010)	1
SRPK2	1	CALCOCO1	2	enzymatic study	Lipp JJ (2015)	1
KRT15	2	TXLNB	0	two hybrid	Rolland T (2014)	1
CALCOCO1	2	GRIK2	4	two hybrid	Wang J (2011)	1
AP2M1	5	CALCOCO1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBC1D17	2	CALCOCO1	2	two hybrid	Stelzl U (2005)	1
AP2M1	5	RALBP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
EP300	36	ARNT	1	affinity chromatography technology	Tohkin M (2000)	1
AP2M1	5	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
HNRNPL	3	GRIK2	4	affinity chromatography technology	Fei T (2017)	1
NEDD4	2	HNRNPL	3	pull down	Ingham RJ (2005)	1