PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UVSSA	5	SIRT1	3	affinity chromatography technology	Fei J (2012)	1
CDK7	0	GTF2H1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rossignol M (1997), Shiekhattar R (1995), Yee A (1995), Kershnar E (1998), Reardon JT (1996), Varjosalo M (2013)	6
ERCC3	3	CDK7	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Rossignol M (1997), Yee A (1995), Jeronimo C (2007), Jeronimo C (2007), Reardon JT (1996), Chen D (1999), Varjosalo M (2013), Huttlin EL (2017), Luo J (2015)	10
UVSSA	5	GTF2H1	0	affinity chromatography technology	Fei J (2012)	1
UVSSA	5	ERCC2	4	affinity chromatography technology	Fei J (2012)	1
BAG6	2	UVSSA	5	affinity chromatography technology	Hein MY (2015)	1
UVSSA	5	ERCC3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fei J (2012), Fei J (2012), Fei J (2012)	3
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
ERCC8	1	UVSSA	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fei J (2012), Fei J (2012), Fei J (2012), Fei J (2012)	4
ERCC2	4	GTF2H1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Drapkin R (1994), Rossignol M (1997), Seroz T (2000), Luo J (2015), Luo J (2015)	5
ERCC3	3	GTF2H1	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giglia-Mari G (2004), Marinoni JC (1997), Rossignol M (1997), Jeronimo C (2007), Drapkin R (1996), Araujo SJ (2001), Havugimana PC (2012), Maru Y (1999), Wan C (2015), Huttlin EL (2017), Luo J (2015), Luo J (2015)	12
CDK7	0	ERCC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reardon JT (1996), Havugimana PC (2012), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	5
DDB1	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Jin J (2006), Groisman R (2003), Groisman R (2003), Meulenbroek EM (2012), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Chitale S (2017), Ohtake F (2007)	10
UVSSA	5	CDK7	0	affinity chromatography technology	Fei J (2012)	1
SYNCRIP	6	UVSSA	5	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	SYNCRIP	6	biochemical	Wan C (2015)	1
HNRNPL	3	UVSSA	5	affinity chromatography technology	Fei T (2017)	1
USP7	14	UVSSA	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Schwertman P (2012), Fei J (2012), Fei J (2012), Higa M (2016), Higa M (2016), Higa M (2016)	6
UVSSA	5	DDB1	6	affinity chromatography technology	Fei J (2012)	1
UVSSA	5	SETD1A	12	affinity chromatography technology	Fei J (2012)	1
ERCC3	3	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1