PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
AKT1	1	SH3RF1	1	enzymatic study	Lyons TR (2007)	1
FAT1	12	SH3RF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	de Bock CE (2017), de Bock CE (2017), de Bock CE (2017)	3
UBE2N	1	SIAH1	2	two hybrid	Markson G (2009)	1
MAP4K3	1	SH3RF1	1	two hybrid	Bandyopadhyay S (2010)	1
SH3RF1	1	MAP3K11	7	pull down, affinity chromatography technology	Figueroa C (2003), Figueroa C (2003)	2
SIAH1	2	UBE2D1	0	two hybrid, two hybrid, pull down, pull down, pull down	Matsuzawa SI (2001), Markson G (2009), Dimitrova YN (2010), Rott R (2008), Liu QY (2008)	5
NINL	1	SH3RF1	1	bioid	Gupta GD (2015)	1
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
TRIM25	5	SH3RF1	1	affinity chromatography technology	Choudhury NR (2017)	1
SH3RF1	1	UBE2D1	0	pull down	Lin DH (2009)	1
SH3RF1	1	SEMA6A	3	two hybrid, two hybrid	Nakayama M (2002), Nakayama M (2002)	2
MAP3K11	7	AKT1	1	affinity chromatography technology, pull down	Barthwal MK (2003), Barthwal MK (2003)	2
CDH1	4	YWHAB	1	bioid	Guo Z (2014)	1
RAC1	7	SH3RF1	1	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Wilhelm M (2012)	2
SIAH2	0	SH3RF1	1	two hybrid, affinity chromatography technology	Christian PA (2011), Christian PA (2011)	2
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
SIAH1	2	SH3RF1	1	affinity chromatography technology, affinity chromatography technology	Xu Z (2006), Xu Z (2006)	2
AKT2	1	SH3RF1	1	two hybrid, pull down, enzymatic study	Figueroa C (2003), Figueroa C (2003), Lyons TR (2007)	3
RAC1	7	SH3RF2	0	affinity chromatography technology	Wilhelm M (2012)	1
YWHAB	1	SH3RF1	1	affinity chromatography technology	Couzens AL (2013)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
SH3RF1	1	KCNJ1	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Lin DH (2009), Lin DH (2009), Lin DH (2009), Lin DH (2009), Lin DH (2009)	5
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	SH3RF1	1	bioid	Guo Z (2014)	1
UBE2N	1	SH3RF2	0	two hybrid	van Wijk SJ (2009)	1
SIAH1	2	HERPUD1	2	affinity chromatography technology, affinity chromatography technology	Miura H (2010), Miura H (2010)	2
PDCD6IP	3	SH3RF1	1	affinity chromatography technology, pull down, enzymatic study	Votteler J (2009), Votteler J (2009), Votteler J (2009)	3
SH3RF1	1	UBE2N	1	pull down, pull down	Votteler J (2009), Tuvia S (2007)	2
TRIM25	5	HERPUD1	2	affinity chromatography technology	Choudhury NR (2017)	1
SIAH2	0	UBE2D1	0	pull down, pull down, pull down	Rott R (2008), Uchiki T (2009), Fan L (2015)	3
SIAH2	0	UBE2D3	1	pull down	Stebbins JL (2013)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
RAC1	7	MAP3K11	7	two hybrid	Nagata K (1998)	1
SH3RF1	1	SH3RF1	1	enzymatic study	Tuvia S (2007)	1
SH3RF1	1	HERPUD1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Tuvia S (2007), Tuvia S (2007), Tuvia S (2007), Tuvia S (2007), Tuvia S (2007)	5
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
SH3RF1	1	UBE2D3	1	pull down, pull down	Votteler J (2009), Tuvia S (2007)	2
SH3RF2	0	SH3RF1	1	affinity chromatography technology, affinity chromatography technology	Wilhelm M (2012), Wilhelm M (2012)	2