PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CYLD	2	SLAIN2	2	affinity chromatography technology	Elliott PR (2016)	1
SLAIN2	2	CCDC61	2	affinity chromatography technology	Hein MY (2015)	1
FXR2	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
CEP128	1	CYLD	2	bioid	Gupta GD (2015)	1
SRPK2	1	YTHDC1	8	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
SLAIN2	2	FOPNL	0	affinity chromatography technology	Hein MY (2015)	1
SRPK2	1	CEP170	4	enzymatic study	Lipp JJ (2015)	1
CNTRL	5	CEP170	4	bioid	Gupta GD (2015)	1
SLAIN2	2	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
CEP170	4	SLAIN2	2	bioid	Gupta GD (2015)	1
SLAIN2	2	PRDX5	0	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
SLAIN2	2	FOCAD	9	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	CKAP5	2	affinity chromatography technology	Ertych N (2016)	1
SLAIN2	2	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
SLAIN2	2	SRSF10	0	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	NPM1	0	unspecified method	Xu D (2012)	1
SLAIN2	2	APP	1	pull down	Olah J (2011)	1
SLAIN2	2	MZT2A	0	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	YBX3	0	affinity chromatography technology	Elliott PR (2016)	1
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
SLAIN2	2	P4HA1	1	affinity chromatography technology	Hein MY (2015)	1
DCTN1	6	NNT	3	bioid	Gupta GD (2015)	1
SRPK1	2	YBX3	0	affinity chromatography technology	So J (2015)	1
CARMIL1	3	SLAIN2	2	biochemical	Havugimana PC (2012)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
XPO1	8	CYLD	2	affinity chromatography technology	Kirli K (2015)	1
PCM1	5	CEP170	4	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MAGEA10	1	SLAIN2	2	affinity chromatography technology	Hein MY (2015)	1
SLAIN2	2	CDT1	2	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Sato K (2004), Ertych N (2016)	2
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SLAIN2	2	LYSMD2	2	affinity chromatography technology	Hein MY (2015)	1
SLAIN2	2	TRIB1	1	affinity chromatography technology	Hein MY (2015)	1
SRPK2	1	MYCBP2	11	enzymatic study	Lipp JJ (2015)	1
CDT1	2	NPM1	0	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
SMURF1	4	SLAIN2	2	enzymatic study	Andrews PS (2010)	1
CNTRL	5	CEP131	9	bioid	Gupta GD (2015)	1
COPS2	5	NPM1	0	affinity chromatography technology	Kob R (2007)	1
SRPK2	1	SLAIN2	2	enzymatic study	Varjosalo M (2013)	1
SLAIN2	2	APPBP2	3	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	CEP170	4	affinity chromatography technology	Kirli K (2015)	1
SMURF1	4	DCTN1	6	affinity chromatography technology	Xie Y (2013)	1
SLAIN2	2	FXR1	0	affinity chromatography technology	Hein MY (2015)	1
HIST1H3E	0	SLAIN2	2	affinity chromatography technology	Campos EI (2015)	1
SLAIN2	2	JARID2	7	affinity chromatography technology	Hein MY (2015)	1
PRDX5	0	APP	1	pull down	Olah J (2011)	1
COPS2	5	YTHDC1	8	genetic interference	Horlbeck MA (2018)	1
NPM1	0	GRB2	2	affinity chromatography technology, pull down	Crockett DK (2004), Bai RY (1998)	2
MZT2A	0	APP	1	pull down	Olah J (2011)	1
SLAIN2	2	TACC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	3
SLAIN2	2	NNT	3	affinity chromatography technology	Hein MY (2015)	1
FXR1	0	FXR2	2	biochemical, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Siomi MC (1996), Zhang Y (1995), Zhang Y (1995), Zhang Y (1995), Li S (2014), Li S (2014), Huttlin EL (2017)	7
SLAIN2	2	YTHDC1	8	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	SLAIN2	2	affinity chromatography technology	Hill SJ (2014)	1
HIST1H3E	0	YBX3	0	affinity chromatography technology	Campos EI (2015)	1
HIST1H3E	0	NPM1	0	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
CEP128	1	CEP131	9	bioid	Gupta GD (2015)	1
SRPK2	1	YBX3	0	enzymatic study	Lipp JJ (2015)	1
SLAIN2	2	WAC	18	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	DCTN1	6	affinity chromatography technology, pull down	Sahni M (1996), Sahni M (1996)	2
POC1A	3	SLAIN2	2	bioid	Gupta GD (2015)	1
SLAIN2	2	PCM1	5	affinity chromatography technology	Hein MY (2015)	1
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
NPM1	0	APP	1	pull down	Olah J (2011)	1
DCTN1	6	SLAIN2	2	bioid	Gupta GD (2015)	1
CNTRL	5	PCM1	5	bioid	Gupta GD (2015)	1
PCM1	5	FOPNL	0	bioid	Gupta GD (2015)	1
MAGEA10	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
CEP170	4	DCTN1	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
KLC2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CEP128	1	FOPNL	0	bioid	Gupta GD (2015)	1
CNTRL	5	SLAIN2	2	bioid	Gupta GD (2015)	1
CEP170	4	CEP131	9	bioid	Gupta GD (2015)	1
GRB2	2	TRIM27	2	two hybrid	Rolland T (2014)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
XPO1	8	CDT1	2	affinity chromatography technology	Kirli K (2015)	1
PCM1	5	CEP131	9	affinity chromatography technology, pull down, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Gupta GD (2015), Gupta GD (2015)	4
SLAIN2	2	RNF20	9	affinity chromatography technology	Hein MY (2015)	1
SLAIN2	2	YBX3	0	affinity chromatography technology	Hein MY (2015)	1
CKAP5	2	SLAIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	4
WAC	18	APP	1	pull down	Olah J (2011)	1
CEP170	4	GRB2	2	bioid	Gupta GD (2015)	1
SRPK1	2	YTHDC1	8	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
SRPK2	1	APP	1	pull down	Olah J (2011)	1
KLC2	2	SLAIN2	2	biochemical	Havugimana PC (2012)	1
NPM1	0	SLAIN2	2	affinity chromatography technology	Chen R (2013)	1
SH3KBP1	1	SLAIN2	2	affinity chromatography technology	Havrylov S (2009)	1
SRPK1	2	SLAIN2	2	enzymatic study	Varjosalo M (2013)	1
SH3KBP1	1	CARMIL1	3	affinity chromatography technology	Havrylov S (2009)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
SRPK2	1	FXR2	2	two hybrid, enzymatic study	Rolland T (2014), Lipp JJ (2015)	2
SLAIN2	2	PCDHA10	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
COPS2	5	SLAIN2	2	biochemical	Havugimana PC (2012)	1
SLAIN2	2	MYCBP2	11	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	DCTN1	6	affinity chromatography technology	Elliott PR (2016)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
SLAIN2	2	TACC2	4	affinity chromatography technology	Hein MY (2015)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
CYLD	2	NPM1	0	affinity chromatography technology	Elliott PR (2016)	1
SH3KBP1	1	KLC2	2	affinity chromatography technology	Huttlin EL (2017)	1
CNTRL	5	CKAP5	2	bioid	Gupta GD (2015)	1
CKAP5	2	TACC2	4	affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Hein MY (2015)	2
CEP128	1	SLAIN2	2	bioid	Gupta GD (2015)	1
SLAIN2	2	TARSL2	1	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	DCTN1	6	affinity chromatography technology	Ertych N (2016)	1
SLAIN2	2	FXR2	2	affinity chromatography technology	Hein MY (2015)	1
CNTRL	5	NNT	3	bioid	Gupta GD (2015)	1
CKAP5	2	TACC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Hein MY (2015), Hein MY (2015)	3
SLAIN2	2	TTC19	0	affinity chromatography technology	Huttlin EL (2017)	1
SLAIN2	2	SS18L2	0	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	CKAP5	2	bioid	Gupta GD (2015)	1
GRB2	2	SLAIN2	2	affinity chromatography technology	Bisson N (2011)	1
NPM1	0	YBX3	0	affinity chromatography technology	Park G (2010)	1
XPO1	8	SLAIN2	2	affinity chromatography technology	Kirli K (2015)	1
RNF20	9	WAC	18	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang F (2011), Zhang F (2011), Zhang F (2011), Duan Y (2016), Huttlin EL (2017)	5
COPS2	5	APPBP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLAIN2	2	CEP131	9	affinity chromatography technology	Hein MY (2015)	1