PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	WDR48	2	affinity chromatography technology	Emdal KB (2015)	1
RNF19B	0	WDR48	2	affinity chromatography technology	Huttlin EL (2017)	1
PAXIP1	1	DKC1	1	affinity chromatography technology	Woods NT (2012)	1
PHLPP1	4	WDR20	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Sowa ME (2009), McClurg UL (2014), St-Denis N (2016), St-Denis N (2016)	4
KDM4A	3	AR	3	affinity chromatography technology	Shin S (2007)	1
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
NTRK1	1	AP3M1	2	affinity chromatography technology	Emdal KB (2015)	1
DKC1	1	SHQ1	1	pull down, affinity chromatography technology, affinity chromatography technology	Walbott H (2011), Huttlin EL (2015), Huttlin EL (2017)	3
NTRK1	1	WRN	6	affinity chromatography technology	Emdal KB (2015)	1
WDR48	2	TARBP1	3	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	DKC1	1	enzymatic study	Zhang M (2011)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CSNK2B	5	affinity chromatography technology	Emdal KB (2015)	1
RAD51	3	RAD51AP1	1	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down	Kovalenko OV (1997), Kovalenko OV (1997), Kovalenko OV (1997), Henson SE (2006), Liang F (2016)	5
BRCA1	7	SUPT6H	7	affinity chromatography technology	Woods NT (2012)	1
CSNK2B	5	BRCA1	7	pull down, two hybrid, pull down	OBrien KA (1999), OBrien KA (1999), OBrien KA (1999)	3
PAXIP1	1	EIF3H	3	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	EIF3H	3	affinity chromatography technology	Ertych N (2016)	1
WDR48	2	CRTAP	0	affinity chromatography technology	Sowa ME (2009)	1
PHLPP2	5	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cukras S (2016), St-Denis N (2016)	3
TP53	0	CSNK2B	5	protein complementation assay	Srivastav RK (2011)	1
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
NTRK1	1	TCOF1	1	affinity chromatography technology	Emdal KB (2015)	1
EIF3H	3	CSNK2A1	15	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
USP46	5	SET	8	affinity chromatography technology	Sowa ME (2009)	1
ZBTB2	1	TP53	0	affinity chromatography technology, pull down	Jeon BN (2009), Jeon BN (2009)	2
TCOF1	1	CSNK2A1	15	affinity chromatography technology	Werner A (2015)	1
WDR48	2	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	PCNA	0	pull down	Cohn MA (2007)	1
SHQ1	1	NAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nallar SC (2011), Nallar SC (2011), Hein MY (2015)	3
JMJD6	1	DKC1	1	affinity chromatography technology	Huttlin EL (2017)	1
RNF19B	0	USP12	1	affinity chromatography technology	Huttlin EL (2017)	1
WDR48	2	UNC13B	8	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	PPP1R9B	1	affinity chromatography technology	Woods NT (2012)	1
WDR48	2	BCR	3	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	GPN1	2	affinity chromatography technology	Bennett EJ (2010)	1
AR	3	WDR20	6	affinity chromatography technology, affinity chromatography technology	McClurg UL (2015), McClurg UL (2015)	2
NAF1	0	NHP2	0	affinity chromatography technology, biochemical, affinity chromatography technology	Trahan C (2009), Wan C (2015), Hein MY (2015)	3
PAXIP1	1	CSNK2A1	15	affinity chromatography technology	Woods NT (2012)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
WDR48	2	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Lee KY (2010), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Cohn MA (2007), Villamil MA (2012), Garcia-Santisteban I (2012), Garcia-Santisteban I (2012), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Cohn MA (2007), Lehoux M (2014), Lehoux M (2014), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016)	25
USP46	5	PHLPP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Li X (2012), Li X (2012), Li X (2012), Huttlin EL (2015), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Gangula NR (2013)	10
PSMA3	1	NELFE	0	biochemical	Wan C (2015)	1
USP12	1	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Jahan AS (2016), McClurg UL (2015), Dharadhar S (2016), Cukras S (2016), Li H (2016), Li H (2016), Gangula NR (2013)	15
WDR48	2	EIF3F	1	affinity chromatography technology	Sowa ME (2009)	1
RNF19B	0	WDR20	6	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	EIF3F	1	affinity chromatography technology	Matsumoto M (2005)	1
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
NHP2	0	JMJD6	1	two hybrid	Weimann M (2013)	1
IWS1	3	SUPT6H	7	affinity chromatography technology, pull down	Yoh SM (2008), Yoh SM (2008)	2
FBXL7	0	WDR48	2	affinity chromatography technology	Tan MK (2013)	1
WDR48	2	YARS	3	biochemical	Wan C (2015)	1
CSNK2A1	15	IWS1	3	enzymatic study	Zhang M (2011)	1
WDR48	2	TCOF1	1	affinity chromatography technology	Sowa ME (2009)	1
PSME3	0	TP53	0	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Zhang Z (2008), Zhang Z (2008), Zhang Z (2008), Liu J (2010), Liu J (2010)	5
USP46	5	PHLPP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	5
EIF3H	3	EIF3F	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
WDR48	2	SUPT6H	7	affinity chromatography technology	Sowa ME (2009)	1
USP46	5	DMWD	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Huttlin EL (2015), Huttlin EL (2017)	5
WDR48	2	P3H1	2	affinity chromatography technology	Sowa ME (2009)	1
PCNA	0	PPIB	1	biochemical	Wan C (2015)	1
WDR48	2	FAM122B	0	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
EIF3A	4	EIF3F	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Mayeur GL (2003), Block KL (1998), Sowa ME (2009), Asano K (1997), Shi J (2009), Havugimana PC (2012), Huttlin EL (2015), Martineau Y (2014), Wan C (2015), Huttlin EL (2017)	11
BRCA1	7	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scully R (1997), Dong Y (2003), Dong Y (2003), Dong Y (2003), Wang Q (2001), Chen J (1998), Mok MT (2010), Scully R (1997), Scully R (1997), Johnson N (2013), Jung YS (2014), Jung YS (2014), Parameswaran B (2015)	13
CUL4B	8	MYCBP2	11	affinity chromatography technology	Bennett EJ (2010)	1
NOP10	1	NHP2	0	two hybrid, biochemical	Rolland T (2014), Wan C (2015)	2
PSMA3	1	AP3M1	2	biochemical	Kristensen AR (2012)	1
NTRK1	1	FANCI	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PSMA3	1	affinity chromatography technology	Emdal KB (2015)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
WDR48	2	PPP1R9A	4	affinity chromatography technology	Sowa ME (2009)	1
SET	8	TP53	0	affinity chromatography technology, pull down	Kim JY (2012), Kim JY (2012)	2
WDR48	2	23246	0	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	SUPT6H	7	enzymatic study	Zhang M (2011)	1
PHLPP2	5	CUL3	17	affinity chromatography technology	Kim K (2017)	1
WDR48	2	DKC1	1	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	AHCYL2	4	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	GPN1	2	enzymatic study	Zhang M (2011)	1
RAD51	3	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, pull down, far western blotting	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006)	5
RAD51	3	FANCI	1	pull down	Sato K (2016)	1
WDR48	2	GPN3	4	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	DMWD	3	affinity chromatography technology	Wimuttisuk W (2014)	1
EIF3A	4	EIF3H	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Mayeur GL (2003), Block KL (1998), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
WDR48	2	NOP10	1	affinity chromatography technology	Sowa ME (2009)	1
USP12	1	RAD51AP1	1	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	EIF3A	4	affinity chromatography technology	Emdal KB (2015)	1
CSNK2A1	15	STK11	2	genetic interference	Srivas R (2016)	1
NAF1	0	DKC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Trahan C (2009), Trahan C (2009), Hoareau-Aveilla C (2006), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
BRCA1	7	POLR2I	0	affinity chromatography technology	Woods NT (2012)	1
NTRK1	1	P3H1	2	affinity chromatography technology	Emdal KB (2015)	1
EIF3F	1	CSNK2A2	1	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	PCNA	0	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Huang TT (2006), Hibbert RG (2012), Juhasz S (2012), Cotto-Rios XM (2011)	4
NTRK1	1	CSNK2A2	1	affinity chromatography technology	Emdal KB (2015)	1
ATAD5	5	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Yang K (2011), Liang F (2016)	3
UBC	7	GPN3	4	affinity chromatography technology	Matsumoto M (2005)	1
GPN3	4	POLR2G	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
NFATC1	12	NFATC2	1	affinity chromatography technology	Gabriel CH (2016)	1
EIF3H	3	CSNK2B	5	affinity chromatography technology	Sowa ME (2009)	1
NFATC1	12	TP53	0	affinity chromatography technology	Li X (2015)	1
P3H1	2	CRTAP	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RAD51	3	CSNK2B	5	two hybrid	Arroyo R (2015)	1
PAXIP1	1	WDR48	2	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
USP46	5	PPP1R9B	1	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	UBC	7	x-ray crystallography	Yin J (2015)	1
WDR48	2	ZBTB2	1	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
PSME3	0	AHCYL1	2	biochemical	Wan C (2015)	1
UBC	7	PSMA3	1	affinity chromatography technology	Matsumoto M (2005)	1
WDR48	2	WRN	6	affinity chromatography technology	Sowa ME (2009)	1
USP46	5	USP12	1	affinity chromatography technology, bioid	Sowa ME (2009), Jahan AS (2016)	2
WDR48	2	CSNK2B	5	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A2	1	TCOF1	1	affinity chromatography technology	Varjosalo M (2013)	1
CSNK2A1	15	BRCA1	7	pull down	OBrien KA (1999)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
EIF3H	3	CSNK2A2	1	affinity chromatography technology	Sowa ME (2009)	1
ITCH	1	PCNA	0	affinity chromatography technology	OConnor HF (2015)	1
PSMA3	1	WDR48	2	affinity chromatography technology	Fedorova OA (2011)	1
GPN1	2	GPN3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	3
RIPK4	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
VSX2	1	AHCYL2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	PPIB	1	affinity chromatography technology	Emdal KB (2015)	1
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
WDR48	2	RAD51	3	pull down	Liang F (2016)	1
RAD51AP1	1	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Huttlin EL (2017)	4
BRCA1	7	TCOF1	1	affinity chromatography technology	Ertych N (2016)	1
TSPYL6	0	WDR48	2	affinity chromatography technology	Huttlin EL (2017)	1
WDR48	2	UBR5	13	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Flack JE (2017)	2
WDR48	2	NAF1	0	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	CTNND1	4	affinity chromatography technology	Emdal KB (2015)	1
PSMA3	1	PSME3	0	biochemical	Wan C (2015)	1
BCR	3	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
RIPK4	0	WDR48	2	affinity chromatography technology	Rodriguez J (2016)	1
NAF1	0	NOP10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trahan C (2009), Hoareau-Aveilla C (2006), Hein MY (2015)	3
WDR48	2	CTNND1	4	affinity chromatography technology	Sowa ME (2009)	1
NAF1	0	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
WDR48	2	EIF3H	3	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	PPIB	1	affinity chromatography technology	Sowa ME (2009)	1
PAXIP1	1	UIMC1	4	affinity chromatography technology	Woods NT (2012)	1
WDR48	2	EIF3A	4	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	STK11	2	affinity chromatography technology, fluorescent resonance energy transfe	Karuman P (2001), Ivanov AA (2017)	2
ITCH	1	WDR48	2	affinity chromatography technology	Moretti J (2012)	1
WDR48	2	MYCBP2	11	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	EIF3A	4	affinity chromatography technology	Ertych N (2016)	1
WDR48	2	C11orf58	0	affinity chromatography technology	Sowa ME (2009)	1
USP1	4	ATAD5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Lee KY (2010), Rahman S (2011)	3
AR	3	USP12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burska UL (2013), McClurg UL (2014), McClurg UL (2015)	3
VSX2	1	WDR48	2	affinity chromatography technology	Huttlin EL (2015)	1
UBC	7	PSME3	0	affinity chromatography technology	Matsumoto M (2005)	1
CRTAP	0	GPN1	2	biochemical	Kristensen AR (2012)	1
WDR48	2	ZBTB33	1	affinity chromatography technology	Sowa ME (2009)	1
RAD51	3	BCR	3	pull down	Slupianek A (2011)	1
WDR48	2	FANCI	1	pull down, affinity chromatography technology, pull down	Yang K (2011), Yang K (2011), Liang F (2016)	3
FANCI	1	PHLPP2	5	affinity chromatography technology	Zhang X (2016)	1
POLR2G	0	POLR2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
PHLPP1	4	PHLPP2	5	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), St-Denis N (2016)	2
WDR48	2	PSME3	0	affinity chromatography technology	Sowa ME (2009)	1
TSPYL6	0	WDR20	6	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	TRMT11	0	affinity chromatography technology	Lunardi A (2010)	1
PHLPP2	5	WDR20	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), McClurg UL (2014), St-Denis N (2016)	3
NTRK1	1	23246	0	affinity chromatography technology	Emdal KB (2015)	1
TSPYL6	0	PSME3	0	affinity chromatography technology	Huttlin EL (2017)	1
WDR48	2	KDM4A	3	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	AP3M1	2	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	POLR2G	0	affinity chromatography technology	Woods NT (2012)	1
CUL3	17	UBR5	13	affinity chromatography technology	Bennett EJ (2010)	1
PAXIP1	1	CSNK2B	5	affinity chromatography technology	Woods NT (2012)	1
CUL3	17	FANCI	1	affinity chromatography technology	Bennett EJ (2010)	1
WDR48	2	IWS1	3	affinity chromatography technology	Sowa ME (2009)	1
PCNA	0	RAD51	3	affinity chromatography technology, imaging technique	Chen X (2016), Sato K (2016)	2
DKC1	1	NOP10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trahan C (2009), Huttlin EL (2015), Huttlin EL (2017)	3
BRCA1	7	UIMC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Kim H (2007), Kim H (2007), Sobhian B (2007), Sobhian B (2007), Sowa ME (2009), Strauss C (2011), Strauss C (2011), Feng L (2009), Feng L (2009), Yan J (2007), Wang B (2007), Wang B (2007), Wang B (2007), Nikkilae J (2009), Nikkilae J (2009), Mok MT (2010), Johnson N (2013), Hill SJ (2014), Hu Y (2014), Hu Y (2014), Hu Y (2014), Renaud E (2016), Li Y (2017)	23
WDR48	2	TRMT11	0	affinity chromatography technology	Sowa ME (2009)	1
NFATC1	12	WDR48	2	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
VSX2	1	WDR20	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCOF1	1	DKC1	1	affinity chromatography technology	Werner A (2015)	1
ITCH	1	USP12	1	affinity chromatography technology, affinity chromatography technology, bioid	Moretti J (2012), Moretti J (2012), Jahan AS (2016)	3
WDR48	2	STK11	2	affinity chromatography technology	Sowa ME (2009)	1
DKC1	1	NHP2	0	affinity chromatography technology, biochemical, biochemical	Trahan C (2009), Havugimana PC (2012), Wan C (2015)	3
USP1	4	UBC	7	enzymatic study, pull down	Faesen AC (2011), Cohn MA (2009)	2
STK11	2	KDM4A	3	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	PCNA	0	affinity chromatography technology	Banks D (2006)	1
ZBTB33	1	TP53	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Koh DI (2014), Koh DI (2014), Koh DI (2014), Koh DI (2015), Koh DI (2015)	5
TSPYL6	0	USP12	1	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	PSME3	0	affinity chromatography technology	Ertych N (2016)	1
WDR48	2	POLR2I	0	affinity chromatography technology	Sowa ME (2009)	1
CUL4B	8	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Nathan JA (2013)	2
NAF1	0	JMJD6	1	affinity chromatography technology	Hein MY (2015)	1
NFATC2	1	SUPT6H	7	affinity chromatography technology	Gabriel CH (2016)	1
WDR48	2	CSNK2A2	1	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
WDR48	2	RAD51AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Cukras S (2016), Cukras S (2016), Cukras S (2016), Huttlin EL (2017), Liang F (2016), Liang F (2016), Liang F (2016)	9
GPN3	4	POLR2I	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AHCYL2	4	AHCYL1	2	affinity chromatography technology	Huttlin EL (2017)	1
WDR48	2	SET	8	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	EIF3H	3	affinity chromatography technology	Matsumoto M (2005)	1
NFATC2	1	WDR48	2	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
WDR48	2	POLR2G	0	affinity chromatography technology	Sowa ME (2009)	1
EIF3F	1	CSNK2A1	15	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
EIF3F	1	DKC1	1	two hybrid	Stelzl U (2005)	1
CTNND1	4	ZBTB33	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Daniel JM (1999), Daniel JM (1999), Ruzov A (2004), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011), Dai SD (2010), Dai SD (2010), Kelly KF (2004), Kelly KF (2004), Zhang J (2010), Jiang G (2012), Liu Y (2014)	14
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
WDR48	2	YLPM1	6	affinity chromatography technology	Sowa ME (2009)	1
JMJD6	1	WDR48	2	affinity chromatography technology	Huttlin EL (2017)	1
WDR48	2	NHP2	0	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	NAF1	0	enzymatic study	Zhang M (2011)	1
USP12	1	PHLPP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), St-Denis N (2016), St-Denis N (2016), Gangula NR (2013), Gangula NR (2013), Gangula NR (2013)	8
WDR48	2	ARHGEF10	4	affinity chromatography technology	Sowa ME (2009)	1
BRCA1	7	GPN1	2	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	GPN3	4	affinity chromatography technology	Woods NT (2012)	1
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
VSX2	1	USP12	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GPN1	2	TCOF1	1	affinity chromatography technology	Jeronimo C (2007)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
POLR2G	0	GPN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
NTRK1	1	SET	8	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	23246	0	affinity chromatography technology	Bennett EJ (2010)	1
TSPYL6	0	USP46	5	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
UBC	7	RNF19B	0	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	USP46	5	pull down	Kwasna D (2018)	1
WDR48	2	GPN1	2	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	GPN1	2	affinity chromatography technology	Matsumoto M (2005)	1
USH1C	2	WDR20	6	affinity chromatography technology	Boldt K (2016)	1
WDR48	2	SHQ1	1	affinity chromatography technology	Sowa ME (2009)	1
USP46	5	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Huttlin EL (2015), Olazabal-Herrero A (2015), Olazabal-Herrero A (2015), Yin J (2015), Yin J (2015), Cukras S (2016), Huttlin EL (2017)	14
AHCYL1	2	C11orf58	0	biochemical	Havugimana PC (2012)	1
CUL3	17	YLPM1	6	affinity chromatography technology	Bennett EJ (2010)	1
WDR48	2	AHCYL1	2	affinity chromatography technology	Sowa ME (2009)	1
USP12	1	WDR20	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Jahan AS (2016), McClurg UL (2015), McClurg UL (2015), Li H (2016), Li H (2016)	8
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
TCOF1	1	NHP2	0	affinity chromatography technology	Werner A (2015)	1
WDR20	6	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kee Y (2010), Kee Y (2010), Kee Y (2010), McClurg UL (2015), Cukras S (2016), Huttlin EL (2017)	8
UBR5	13	SET	8	biochemical	Wan C (2015)	1
UBC	7	USP12	1	pull down	Cohn MA (2009)	1
NTRK1	1	CSNK2A1	15	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
CUL3	17	P3H1	2	affinity chromatography technology	Bennett EJ (2010)	1
VSX2	1	CSNK2A2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	CUL4B	8	affinity chromatography technology	Emdal KB (2015)	1
WDR48	2	WDR70	1	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
EIF3F	1	CSNK2B	5	affinity chromatography technology	Sowa ME (2009)	1
PCNA	0	ATAD5	5	pull down, affinity chromatography technology, affinity chromatography technology	Lee KY (2010), Lee KY (2010), Hein MY (2015)	3
AR	3	WDR48	2	affinity chromatography technology	McClurg UL (2015)	1
NTRK1	1	EIF3H	3	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	USP1	4	genetic interference	Xie L (2013)	1
VSX2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WDR48	2	BASP1	1	biochemical	Wan C (2015)	1
FBXL7	0	AHCYL1	2	affinity chromatography technology	Tan MK (2013)	1
NTRK1	1	WDR70	1	affinity chromatography technology	Emdal KB (2015)	1
WDR48	2	PHLPP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), Cukras S (2016), St-Denis N (2016), St-Denis N (2016), Gangula NR (2013), Gangula NR (2013), Gangula NR (2013), Gangula NR (2013)	10
DMWD	3	PHLPP1	4	affinity chromatography technology	Sowa ME (2009)	1
WDR48	2	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
UBC	7	EIF3A	4	pull down	Zhang X (2017)	1
RNF19B	0	USP46	5	affinity chromatography technology	Huttlin EL (2017)	1
USP46	5	RAD51AP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
WDR48	2	DMWD	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
NTRK1	1	NELFE	0	affinity chromatography technology	Emdal KB (2015)	1
WDR48	2	PPP1R9B	1	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	YARS	3	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	BCR	3	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
PHLPP1	4	FANCI	1	affinity chromatography technology, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
WRN	6	TP53	0	affinity chromatography technology, pull down, pull down	Yang Q (2002), Yang Q (2002), Brosh RM (2001)	3
WDR48	2	NELFE	0	affinity chromatography technology	Sowa ME (2009)	1
PHLPP1	4	USP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Zhiqiang Z (2012), Zhiqiang Z (2012), Zhiqiang Z (2012), Cukras S (2016), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Gangula NR (2013)	10
USP12	1	PHLPP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), St-Denis N (2016)	4
UBC	7	TCOF1	1	pull down	Zhang X (2017)	1
NTRK1	1	BCR	3	affinity chromatography technology	Emdal KB (2015)	1
UIMC1	4	WDR48	2	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A2	1	BCR	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
USP46	5	USH1C	2	affinity chromatography technology	Boldt K (2016)	1
WDR48	2	CSNK2A1	15	affinity chromatography technology	Sowa ME (2009)	1
CSNK2A1	15	ATAD5	5	genetic interference	Srivas R (2016)	1
P3H1	2	GPN1	2	biochemical	Kristensen AR (2012)	1
PHLPP2	5	DMWD	3	affinity chromatography technology	St-Denis N (2016)	1
NTRK1	1	EIF3F	1	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	MYCBP2	11	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	CTNND1	4	affinity chromatography technology	Bennett EJ (2010)	1
CSNK2A1	15	PSMA3	1	enzymatic study	Zhang M (2011)	1
USP12	1	DMWD	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011)	3
WDR48	2	CUL4B	8	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
RAD51	3	TP53	0	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dong Y (2003), Dong Y (2003), Dong Y (2003), Stuerzbecher HW (1996), Stuerzbecher HW (1996), Buchhop S (1997), Nakai-Murakami C (2007), Yang Q (2004), Rasti M (2015), Rasti M (2015)	10
WDR48	2	BRCA1	7	affinity chromatography technology	Sowa ME (2009)	1
NTRK1	1	DKC1	1	affinity chromatography technology	Emdal KB (2015)	1
USP46	5	WDR20	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kee Y (2010), Joo HY (2011), Huttlin EL (2015), Huttlin EL (2017)	6
CUL3	17	WDR48	2	affinity chromatography technology	Wimuttisuk W (2014)	1
RNF19B	0	AP3M1	2	affinity chromatography technology	Huttlin EL (2017)	1
SET	8	C11orf58	0	biochemical	Havugimana PC (2012)	1
WDR48	2	PHLPP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), McClurg UL (2014), Cukras S (2016), St-Denis N (2016), Yadav L (2017)	6
TP53	0	SUPT6H	7	affinity chromatography technology	Fogeron ML (2013)	1
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
WDR48	2	ZNF639	3	affinity chromatography technology	Sowa ME (2009)	1