Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
KCNT1	57582	LOXAPINE	CHEMBL831	activator	GuideToPharmacologyInteractions
KCNT1	57582	NICLOSAMIDE	CHEMBL1448	activator	GuideToPharmacologyInteractions
KCNT1	57582	CLOFILIUM	CHEMBL9484	channel blocker	GuideToPharmacologyInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
KCNT1	rs11103182	G	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele G is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699038
KCNT1	rs498974	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699006
KCNT1	rs10735239	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699026
KCNT1	rs11103167	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699030
KCNT1	rs487750	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses). Please note alleles have been complemented to the plus chromosomal strand.	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183698998
KCNT1	rs755722	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699022
KCNT1	rs1318383	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses). Please note alleles have been complemented to the plus chromosomal strand.	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183699042
KCNT1	rs10118746	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183699034
KCNT1	rs10776845	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele C.	24279416	1183699046
KCNT1	rs10776850	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699050
KCNT1	rs10858173	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699054
KCNT1	rs496503	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183698994
KCNT1	rs498618	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses). Please note alleles have been complemented to the plus chromosomal strand.	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183699010
KCNT1	rs546120	A	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses). Please note alleles have been complemented to the plus chromosomal strand.	Allele A is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183698989
KCNT1	rs1165016	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses). Please note alleles have been complemented to the plus chromosomal strand.	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699002
KCNT1	rs1537416	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele T.	24279416	1183699014
KCNT1	rs7855716	C	antiepileptics	efficacy	no	No significant differences in genotype frequencies were seen between patients who were responsive to antiepileptic drugs (n=279; those who had not experienced any type of seizure for a minimum of 1 year after receiving antiepileptic drugs) and patients who were resistant to antiepileptic drugs (n=204; those who had at least four seizures during the previous year while trying at least three antiepileptic medications at the maximal tolerated doses).	Allele C is not associated with response to antiepileptics in people with Epilepsy, Generalized as compared to allele G.	24279416	1183699018