PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SSX2IP	0	SIPA1L2	4	bioid	Gupta GD (2015)	1
NINL	1	SIPA1L2	4	bioid	Gupta GD (2015)	1
PCGF1	1	DPPA4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015)	5
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
ODF2	1	SIPA1L2	4	bioid	Gupta GD (2015)	1
DPPA4	0	SIPA1L2	4	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	SIPA1L2	4	affinity chromatography technology	Oliviero G (2015)	1
RPL28	0	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
LATS2	1	LATS1	3	affinity chromatography technology, bioid	Xiao L (2011), Couzens AL (2013)	2
PRG2	2	SIPA1L2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
EGLN3	0	TSPYL1	3	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
POU5F1	0	DPPA4	0	affinity chromatography technology	Oliviero G (2015)	1
CEP128	1	LZTS2	4	bioid	Gupta GD (2015)	1
CELA1	3	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
PCGF1	1	SIPA1L2	4	affinity chromatography technology	Oliviero G (2015)	1
LATS2	1	NINL	1	bioid	Couzens AL (2013)	1
NXF2	0	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	PCGF1	1	affinity chromatography technology	Rodriguez J (2016)	1
LATS2	1	SIPA1L2	4	bioid	Couzens AL (2013)	1
LATS1	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
YWHAB	1	SIPA1L2	4	affinity chromatography technology	Couzens AL (2013)	1
NINL	1	LATS1	3	bioid	Gupta GD (2015)	1
DYRK1B	1	SIPA1L2	4	affinity chromatography technology	Varjosalo M (2013)	1
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
APOBEC3D	0	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
PCGF1	1	NANOG	0	biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015)	2
LATS1	3	SIPA1L2	4	bioid	Couzens AL (2013)	1
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP135	2	SIPA1L2	4	bioid	Gupta GD (2015)	1
EGLN3	0	LZTS2	4	affinity chromatography technology	Rodriguez J (2016)	1
LZTS2	4	SSX2IP	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP250	4	LZTS2	4	affinity chromatography technology	Fogeron ML (2013)	1
RPGRIP1L	2	SIPA1L2	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
RPGRIP1L	2	LZTS2	4	bioid	Gupta GD (2015)	1
RPGRIP1L	2	SSX2IP	0	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
LATS2	1	SSX2IP	0	bioid	Couzens AL (2013)	1
LATS2	1	LZTS2	4	bioid	Couzens AL (2013)	1
CEP128	1	SIPA1L2	4	bioid	Gupta GD (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	LZTS2	4	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	LZTS2	4	bioid	Gupta GD (2015)	1
LZTS2	4	SIPA1L2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP3M1	2	SIPA1L2	4	two hybrid	Rolland T (2014)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
C6orf141	1	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
LATS1	3	LZTS2	4	bioid	Couzens AL (2013)	1
SIPA1L2	4	TGM2	2	two hybrid	Wang J (2011)	1
NANOG	0	SIPA1L2	4	affinity chromatography technology	Oliviero G (2015)	1
PROZ	0	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP250	4	SIPA1L2	4	affinity chromatography technology	Fogeron ML (2013)	1
EGLN3	0	SSX2IP	0	affinity chromatography technology	Rodriguez J (2016)	1
CEP250	4	SSX2IP	0	affinity chromatography technology	Fogeron ML (2013)	1
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
FBXW11	2	SIPA1L2	4	affinity chromatography technology	Low TY (2014)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP250	4	NINL	1	affinity chromatography technology	Fogeron ML (2013)	1
DYRK1B	1	LZTS2	4	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2017)	4
TSPYL1	3	SIPA1L2	4	affinity chromatography technology	Huttlin EL (2017)	1
ORC5	0	SIPA1L2	4	two hybrid	Wang J (2011)	1
EGLN3	0	SIPA1L2	4	affinity chromatography technology	Rodriguez J (2016)	1