PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
SOCS3	0	REL	5	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
LINC01139	0	EGFR	5	affinity chromatography technology, unspecified method	Lin A (2016), Lin A (2016)	2
FCHO1	3	APP	1	pull down	Olah J (2011)	1
ERBB3	3	PTK6	1	affinity chromatography technology, unspecified method	Kamalati T (2000), Jones RB (2006)	2
ERBB2	6	DOK1	2	unspecified method	Jones RB (2006)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
EGFR	5	STAP2	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Kitai Y (2017)	3
HSP90AA1	7	ERBB2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu W (2001), Jeong JH (2008), Mollapour M (2010), Citri A (2002), Jung Y (2007), Suzuki T (2011), Tsutsumi S (2012), Taipale M (2012), Bali P (2005), Woodford MR (2016), Yan YY (2011), Yan YY (2011)	12
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
PTK6	1	REL	5	two hybrid	Rolland T (2014)	1
TRIM25	5	KHDRBS1	1	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
CCDC33	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TCP1	0	CCT4	2	affinity chromatography technology, biochemical, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PTK6	1	PTK6	1	enzymatic study, enzymatic study	Xiang B (2008), Lin A (2016)	2
TRIM25	5	CCT3	1	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PTK6	1	KHDRBS2	1	two hybrid	Rolland T (2014)	1
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
PTK6	1	TCP1	0	affinity chromatography technology	So J (2015)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PTK6	1	EXOC5	2	two hybrid	Rolland T (2014)	1
HNRNPL	3	STAP2	3	affinity chromatography technology	Fei T (2017)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
CCT4	2	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
EGFR	5	WASL	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HNRNPL	3	PTK6	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
CCT3	1	CCT8	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
STAP2	3	PTK6	1	two hybrid, pull down	Mitchell PJ (2000), Mitchell PJ (2000)	2
TRIM25	5	PTK6	1	affinity chromatography technology	Choudhury NR (2017)	1
FGFR1	2	ERBB3	3	unspecified method	Jones RB (2006)	1
TRIM25	5	CCT4	2	affinity chromatography technology	Choudhury NR (2017)	1
ADAM15	2	PTK6	1	affinity chromatography technology	Zhong JL (2008)	1
HSP90AA1	7	TCP1	0	affinity chromatography technology	Falsone SF (2005)	1
EGFR	5	EXOC5	2	affinity chromatography technology	Foerster S (2013)	1
PTK6	1	CCT4	2	affinity chromatography technology	So J (2015)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	PTK6	1	affinity chromatography technology	Taipale M (2012)	1
EGFR	5	TCP1	0	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
PTK6	1	APP	1	pull down	Olah J (2011)	1
EGFR	5	PTK6	1	affinity chromatography technology, unspecified method	Kamalati T (1996), Jones RB (2006)	2
PTK6	1	ERBB2	6	affinity chromatography technology, affinity chromatography technology	Xiang B (2008), Xiang B (2008)	2
CCT8	0	APP	1	pull down	Olah J (2011)	1
WASL	2	APP	1	pull down	Olah J (2011)	1
LINC01139	0	PTK6	1	affinity chromatography technology, unspecified method	Lin A (2016), Lin A (2016)	2
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PTK6	1	EFHC2	0	two hybrid	Rolland T (2014)	1
PTK6	1	CCT8	0	affinity chromatography technology	So J (2015)	1
PTK6	1	WASL	2	two hybrid	Rolland T (2014)	1
DOK1	2	PTK6	1	unspecified method	Liu BA (2012)	1
HSP90AA1	7	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Vecchione A (2007)	2
PTK6	1	CCDC33	3	two hybrid	Rolland T (2014)	1
HSP90AA1	7	ERBB3	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Li J (2013)	2
TRIM25	5	EFHC2	0	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	ERBB2	6	affinity chromatography technology	Fei T (2017)	1
WASL	2	HSP90AA1	7	pull down	Park SJ (2005)	1
SOCS3	0	APP	1	pull down	Olah J (2011)	1
LINC01139	0	HIF1A	1	affinity chromatography technology, unspecified method	Lin A (2016), Lin A (2016)	2
PTK6	1	FCHO1	3	two hybrid	Rolland T (2014)	1
PTK6	1	SOCS3	0	affinity chromatography technology, affinity chromatography technology	Gao Y (2012), Gao Y (2012)	2
TRIM25	5	ADAM15	2	affinity chromatography technology	Choudhury NR (2017)	1
PTK6	1	HIF1A	1	enzymatic study	Lin A (2016)	1
FGFR1	2	PTK6	1	unspecified method	Liu BA (2012)	1
KHDRBS2	1	HNRNPL	3	affinity chromatography technology	Jeronimo C (2007)	1
PTK6	1	CCT3	1	affinity chromatography technology	So J (2015)	1
KHDRBS2	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
TCP1	0	CCT8	0	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
PTK6	1	KHDRBS1	1	affinity chromatography technology, pull down, enzymatic study	Derry JJ (2000), Derry JJ (2000), Derry JJ (2000)	3
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
HNRNPL	3	HIF1A	1	affinity chromatography technology	Fei T (2017)	1
CCT4	2	CCT8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2