PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KIF11	5	DCTN1	6	two hybrid, pull down	Blangy A (1997), Blangy A (1997)	2
CDC14A	4	MTUS1	6	bioid	St-Denis N (2016)	1
KIF11	5	MTUS1	6	affinity chromatography technology	Hein MY (2015)	1
FHL3	0	MTUS2	4	two hybrid	Yu H (2011)	1
SKP1	0	RING1	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
MTUS2	4	MTUS1	6	affinity chromatography technology	Huttlin EL (2017)	1
FHL3	0	MTUS1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCTN1	6	MTUS1	6	bioid	Gupta GD (2015)	1
NINL	1	MTUS1	6	bioid	Gupta GD (2015)	1
SMC1A	15	MTUS1	6	affinity chromatography technology	Hein MY (2015)	1
SKP1	0	MTUS1	6	affinity chromatography technology	Hauri S (2016)	1
DYNLT1	3	MTUS1	6	bioid	Gupta GD (2015)	1
AGTR2	2	MTUS1	6	two hybrid, affinity chromatography technology	Nouet S (2004), Nouet S (2004)	2
FBXO7	1	CLTC	12	affinity chromatography technology	Teixeira FR (2016)	1
FBXO7	1	MTUS1	6	enzymatic study	Teixeira FR (2016)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
MAGEA10	1	MTUS1	6	affinity chromatography technology	Hein MY (2015)	1
LCA5	1	MTUS1	6	bioid	Gupta GD (2015)	1
CDC14A	4	SPICE1	2	bioid	St-Denis N (2016)	1
POC1A	3	MTUS1	6	bioid	Gupta GD (2015)	1
MMS19	5	MTUS1	6	affinity chromatography technology	Stehling O (2012)	1
DYNLT1	3	DCTN1	6	bioid	Gupta GD (2015)	1
FBXO7	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Hsu JM (2004), Nelson DE (2011), Hagens O (2006), Kang J (2014), Winston JT (1999), Hein MY (2015), Hein MY (2015), Vingill S (2016), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Teixeira FR (2016), Hauri S (2016)	16
MTUS1	6	ORC4	1	two hybrid	Wang J (2011)	1
MTUS1	6	CLUH	8	affinity chromatography technology	Huttlin EL (2017)	1
DCTN1	6	CLTC	12	bioid	Gupta GD (2015)	1
CLTC	12	MTUS1	6	affinity chromatography technology	Hein MY (2015)	1
SPICE1	2	MTUS1	6	bioid	Gupta GD (2015)	1
RING1	2	MTUS1	6	affinity chromatography technology	Hauri S (2016)	1
CEP104	4	MTUS1	6	bioid	Gupta GD (2015)	1