PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC5	4	ANKRA2	0	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology	Wang AH (2005), Xu C (2012), Nie J (2015), Nie J (2015)	4
ESR1	0	HDAC5	4	pull down	van Rooij E (2010)	1
AHRR	5	ANKRA2	0	affinity chromatography technology	Oshima M (2007)	1
AHRR	5	HDAC4	10	affinity chromatography technology	Oshima M (2007)	1
AHRR	5	ESR1	0	affinity chromatography technology	Kanno Y (2008)	1
AHRR	5	HDAC5	4	affinity chromatography technology	Oshima M (2007)	1
HDAC5	4	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Backs J (2008), Backs J (2008), Rui J (2012), Rui J (2012)	4
HDAC4	10	ANKRA2	0	two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology	Wang AH (2005), Wang AH (2005), Xu C (2012), Rolland T (2014), Nie J (2015)	5
ARNT	1	AHRR	5	affinity chromatography technology, two hybrid	Mimura J (1999), Mimura J (1999)	2
ARNT	1	ESR1	0	pull down	Beischlag TV (2005)	1
ESR1	0	HDAC4	10	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	van Rooij E (2010), Leong H (2005), Leong H (2005), Leong H (2005), Leong H (2005)	5