PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP162	3	PLEKHG1	3	bioid	Gupta GD (2015)	1
LLGL2	4	PLEKHG1	3	affinity chromatography technology	Hein MY (2015)	1
OFD1	3	PLEKHG1	3	bioid	Gupta GD (2015)	1
TUBGCP5	6	PLEKHG1	3	affinity chromatography technology	Hein MY (2015)	1
CEP162	3	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP135	2	PLEKHG1	3	bioid	Gupta GD (2015)	1
CEP128	1	PLEKHG1	3	bioid	Gupta GD (2015)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
CEP128	1	ANKRD28	1	bioid	Gupta GD (2015)	1
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
NINL	1	PLEKHG1	3	bioid	Gupta GD (2015)	1
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
LATS2	1	NINL	1	bioid	Couzens AL (2013)	1
RPGRIP1L	2	PLEKHG1	3	bioid	Gupta GD (2015)	1
SSX2IP	0	OFD1	3	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
LATS2	1	OFD1	3	bioid	Couzens AL (2013)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
SSX2IP	0	PLEKHG1	3	bioid	Gupta GD (2015)	1
ODF2	1	OFD1	3	bioid	Gupta GD (2015)	1
CHST15	1	PLEKHG1	3	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
ODF2	1	PLEKHG1	3	bioid	Gupta GD (2015)	1
ODF2	1	ANKRD28	1	bioid	Gupta GD (2015)	1
LATS2	1	CEP89	2	bioid	Couzens AL (2013)	1
RPGRIP1L	2	ANKRD28	1	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
RPGRIP1L	2	SSX2IP	0	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP162	3	CEP89	2	bioid	Gupta GD (2015)	1
LATS2	1	SSX2IP	0	bioid	Couzens AL (2013)	1
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP89	2	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ANKRD28	1	CEP162	3	bioid	Couzens AL (2013)	1
LATS2	1	PLEKHG1	3	bioid	Couzens AL (2013)	1
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP128	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
ANKRD28	1	PLEKHG1	3	bioid	Couzens AL (2013)	1
MYH13	9	PLEKHG1	3	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP162	3	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP89	2	PLEKHG1	3	bioid	Gupta GD (2015)	1