PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
PTGS2	0	PTGS2	0	pull down, pull down, pull down, x-ray crystallography	Dong L (2013), Yuan C (2006), Dong L (2011), Orlando BJ (2016)	4
PTGS2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology	Chen SF (2013), Chen SF (2013)	2
MAPK3	4	PTGS2	0	affinity chromatography technology	Lin C (2011)	1
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
PTGS2	0	AGTR1	4	affinity chromatography technology, affinity chromatography technology	Sood R (2014), Sood R (2014)	2
ELAVL1	0	CELF2	5	pull down, two hybrid, two hybrid	Sureban SM (2007), Sureban SM (2007), Sureban SM (2007)	3
AGTR1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO1	0	PTGS2	0	affinity chromatography technology	Lin C (2011)	1
ELAVL1	0	CASK	18	affinity chromatography technology	Abdelmohsen K (2009)	1
VCP	6	SUMO1	0	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
ELMO1	2	PTGS2	0	affinity chromatography technology, affinity chromatography technology	Yang C (2011), Yang C (2011)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
DERL1	2	APP	1	pull down	Olah J (2011)	1
SELENOS	0	HSPA4	3	affinity chromatography technology	Ye Y (2004)	1
COPS7A	0	PTGS2	0	affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
LMAN2L	0	PTGS2	0	affinity chromatography technology	Huttlin EL (2017)	1
PTGS2	0	PSMC5	4	affinity chromatography technology	Neuss H (2007)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
COPS7A	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
RBX1	2	APP	1	pull down	Olah J (2011)	1
CAV1	0	DERL1	2	affinity chromatography technology	Chen SF (2013)	1
CTNNB1	30	COPS3	1	affinity chromatography technology	Huang X (2009)	1
CAV1	0	SELENOS	0	affinity chromatography technology	Chen SF (2013)	1
PTGS2	0	SELENOS	0	affinity chromatography technology	Chen SF (2013)	1
PTGS2	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Tang HY (2006), Lin C (2011)	2
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
PTGIS	6	APP	1	pull down	Olah J (2011)	1
FAF2	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
PTGS1	4	PTGIS	6	fluorescent resonance energy transfe	Ruan CH (2011)	1
ELAVL1	0	PTGS2	0	unspecified method, affinity chromatography technology, unspecified method	Kim I (2012), Kim I (2012), Sureban SM (2007)	3
PTGS2	0	COPS5	0	biochemical, affinity chromatography technology, pull down	Neuss H (2007), Neuss H (2007), Neuss H (2007)	3
CELF2	5	PTGS2	0	unspecified method	Sureban SM (2007)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
HNRNPD	3	PTGS2	0	affinity chromatography technology	Kishor A (2013)	1
PTGS2	0	NUCB1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Leclerc P (2008), Leclerc P (2008), Leclerc P (2008), Leclerc P (2008)	4
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
CTNNB1	30	COPS5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang X (2009), Jumpertz S (2014), Jumpertz S (2014)	3
CUL4A	2	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Min KW (2005), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	10
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
COPS3	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
PTGS2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Liou JY (2001), Liou JY (2001), Liou JY (2001), Chen SF (2010), Liou JY (2001), Liou JY (2001), Chen SF (2013), Chen SF (2013), Chen SF (2013)	9
PSMC5	4	VCP	6	affinity chromatography technology	Braunstein I (2015)	1
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
CUL1	7	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
HSPA4	3	PTGS2	0	affinity chromatography technology	Kishor A (2013)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
PTGS2	0	PSMD1	2	affinity chromatography technology	Neuss H (2007)	1
CUL4A	2	CTNNB1	30	affinity chromatography technology	Tripathi R (2007)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
PTGS2	0	CASK	18	two hybrid	Corominas R (2014)	1
SELENOS	0	FAF2	4	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012)	2
CAV1	0	MAPK3	4	affinity chromatography technology	Hua H (2003)	1
PTGS2	0	PTGIS	6	fluorescent resonance energy transfe	Ruan CH (2011)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
CTNNB1	30	PTGS2	0	unspecified method, affinity chromatography technology	Kim I (2012), Kim I (2012)	2
CELF2	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
TP53	0	PTGS2	0	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	King JG (2001), Choi EM (2009), Choi EM (2009), Choi EM (2009), Tang HY (2006), Tang HY (2006), Lin C (2011), Lin C (2011), Choi EM (2005), Choi EM (2005), Choi EM (2005), Choi EM (2005)	12
VCP	6	COPS7A	0	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
VCP	6	MAPK3	4	affinity chromatography technology	Yu CC (2013)	1
PTGS2	0	APP	1	affinity chromatography technology, affinity chromatography technology	Nagano S (2004), Nagano S (2004)	2
PTGS2	0	USP22	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Xiao H (2015), Xiao H (2015), Xiao H (2015), Xiao H (2015)	4
PTGS2	0	COPS3	1	affinity chromatography technology	Neuss H (2007)	1
CTNNB1	30	EP300	36	genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, genetic interference, affinity chromatography technology	Kennell JA (2003), Sun Y (2000), Sun Y (2000), Sun Y (2000), Saegusa M (2005), Daniels DL (2002), Levy L (2004), Labalette C (2004), Lee YH (2006), Zhao Y (2016)	10
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
VCP	6	COPS3	1	affinity chromatography technology	Yu CC (2013)	1
PTGS1	4	PTGS2	0	affinity chromatography technology, affinity chromatography technology	Bolego C (2009), Bolego C (2009)	2
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
PTGS2	0	PTGER1	2	affinity chromatography technology	Sood R (2014)	1
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
PTGS1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Cha SH (2004), Cha SH (2004)	2
HNRNPD	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down	Sinsimer KS (2008), Laroia G (1999), Lu JY (2006)	3
CUL4A	2	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Hein MY (2015)	7
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
COPS5	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
CAV1	0	PTGIS	6	pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Spisni E (2001), Spisni E (2001), Spisni E (2001), Spisni E (2001)	4
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
FAF2	4	PTGS2	0	affinity chromatography technology	Raman M (2015)	1
DERL1	2	PSMD1	2	affinity chromatography technology	You H (2017)	1
COPS5	0	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
CAV1	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Li Y (2008), Rodriguez DA (2009)	2
PTGS2	0	CUL4A	2	affinity chromatography technology	Neuss H (2007)	1
CUL4A	2	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
SELENOS	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ballar P (2007), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Zhong Y (2011), Christianson JC (2012)	7
PTGS2	0	CUL1	7	affinity chromatography technology	Neuss H (2007)	1
FAF2	4	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
PTGS2	0	RBX1	2	affinity chromatography technology	Neuss H (2007)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
PSMD1	2	PSMC5	4	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hartmann-Petersen R (2001), Park Y (2005), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	7