PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTGIS	6	APP	1	pull down	Olah J (2011)	1
PTGS1	4	PTGIS	6	fluorescent resonance energy transfe	Ruan CH (2011)	1
PTGS2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Liou JY (2001), Liou JY (2001), Liou JY (2001), Chen SF (2010), Liou JY (2001), Liou JY (2001), Chen SF (2013), Chen SF (2013), Chen SF (2013)	9
PTGS2	0	PTGIS	6	fluorescent resonance energy transfe	Ruan CH (2011)	1
PTGS2	0	APP	1	affinity chromatography technology, affinity chromatography technology	Nagano S (2004), Nagano S (2004)	2
PTGS1	4	PTGS2	0	affinity chromatography technology, affinity chromatography technology	Bolego C (2009), Bolego C (2009)	2
PTGS1	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Cha SH (2004), Cha SH (2004)	2
CAV1	0	PTGIS	6	pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Spisni E (2001), Spisni E (2001), Spisni E (2001), Spisni E (2001)	4
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2