PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PTGDS	0	PTGDS	0	x-ray crystallography, enzymatic study	Inoue T (2003), Inoue T (2003)	2
AKT1	1	PTGDS	0	two hybrid	Arroyo R (2015)	1
PTGDS	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
PTGDS	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
PTGDR	1	HSP90AA1	7	affinity chromatography technology	Binda C (2014)	1
SHBG	0	PTGDS	0	two hybrid	Pope SN (2005)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
FBXW7	2	PTGDS	0	genetic interference	Bailey ML (2015)	1
RARRES3	0	PTGDS	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Wu CC (2012), Wu CC (2012), Wu CC (2012)	3
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
ATXN1	2	PTGDS	0	two hybrid	Lim J (2006)	1
ARRB2	5	PTGDS	0	two hybrid, pull down, affinity chromatography technology, pull down	Mathurin K (2011), Mathurin K (2011), Mathurin K (2011), Mathurin K (2011)	4
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
MLH1	6	PTGDS	0	two hybrid	Brieger A (2010)	1
EGFR	5	PTGDS	0	protein complementation assay	Deribe YL (2009)	1
ARRB2	5	CAPN1	3	affinity chromatography technology	Xiao K (2007)	1
CAPN1	3	PTGDS	0	two hybrid	Jiang LQ (2002)	1
PTGDS	0	CHN2	2	affinity chromatography technology	Huttlin EL (2017)	1
PTGDS	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, pull down	Binda C (2014), Binda C (2014), Binda C (2014)	3
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
RARRES3	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Matsumiya T (2009), Matsumiya T (2009)	2
ORM1	2	PTGDS	0	affinity chromatography technology	Huttlin EL (2017)	1
BCAT2	3	PTGDS	0	two hybrid	Wang J (2011)	1
PTGDR	1	PTGDS	0	pull down, affinity chromatography technology, affinity chromatography technology	Binda C (2014), Binda C (2014), Binda C (2014)	3
CACNA1A	21	PTGDS	0	two hybrid	Kahle JJ (2011)	1