PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
ETS1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee S (2008), Lee S (2008), Kim E (2003), Zhu M (2014)	4
TRIM25	5	NOTCH1	25	affinity chromatography technology	Choudhury NR (2017)	1
AR	3	SMAD3	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Hayes SA (2001), Chipuk JE (2002), Hayes SA (2001), Hayes SA (2001), Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002), Chipuk JE (2002)	12
CTNNB1	30	SIRT1	3	affinity chromatography technology	Holloway KR (2010)	1
PIAS3	2	SMAD4	9	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
AR	3	PIAS3	2	two hybrid	Kotaja N (2000)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
ZMIZ1	7	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Pinnell N (2015), Pinnell N (2015), Pinnell N (2015), Pinnell N (2015)	4
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
SATB1	1	PIAS3	2	two hybrid, two hybrid	Tan JA (2010), Tan JA (2008)	2
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
ZMIZ1	7	SIRT1	3	affinity chromatography technology	Pinnell N (2015)	1
SIRT1	3	ZEB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Byles V (2012), Zhang P (2014), Sun L (2015)	3
ZMIZ1	7	PIAS3	2	two hybrid	Peng Y (2010)	1
NANOG	0	ZMIZ1	7	affinity chromatography technology	Oliviero G (2015)	1
SIRT1	3	SATB1	1	affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study	Xue Z (2012), Xue Z (2012), Xue Z (2012), Xue Z (2012)	4
CTNNB1	30	SATB1	1	pull down, affinity chromatography technology, affinity chromatography technology	Notani D (2010), Notani D (2010), Notani D (2010)	3
ZMIZ1	7	SETD4	1	biochemical	Wan C (2015)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
ETS1	4	SMAD3	1	imaging technique	Chen TC (2014)	1
ZMIZ1	7	RBPJ	1	affinity chromatography technology, affinity chromatography technology	Pinnell N (2015), Pinnell N (2015)	2
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
ZMIZ1	7	CCR7	1	affinity chromatography technology	Pinnell N (2015)	1
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
NANOG	0	BCLAF1	5	affinity chromatography technology	Oliviero G (2015)	1
BRCA1	7	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li H (2010), Li H (2010), Li H (2010), Ertych N (2016)	4
SIRT1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhao W (2008), Liu X (2011), Inoue Y (2011), Jain AK (2012), Langley E (2002), Langley E (2002), Langley E (2002), Kim JE (2008), Kim JE (2008), Kim EJ (2007), Kim EJ (2007), Busch F (2012), Busch F (2012), Hasegawa K (2008), Hasegawa K (2008), Hasegawa K (2008), Zannini L (2012)	17
ETS1	4	AR	3	imaging technique	Chen TC (2014)	1
ZMIZ1	7	TRIM28	1	affinity chromatography technology	Pinnell N (2015)	1
NOTCH1	25	RBPJ	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nam Y (2003), Aster JC (1997), Aster JC (1997), Gao J (2010), Gao J (2010), Kim MY (2007), Kim MY (2007), Popko-Scibor AE (2011), Mo JS (2007), Kim MY (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Choi YH (2013), Jeffries S (2002), Jeffries S (2002), Jeffries S (2002), Kitagawa M (2001), Cho S (2011), Baek HJ (2015), Baek HJ (2015), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017), Tremblay CS (2009), Tremblay CS (2009)	27
ZMIZ1	7	SATB1	1	affinity chromatography technology	Pinnell N (2015)	1
MAML1	5	RBPJ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Jeffries S (2002), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	6
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	ZMIZ1	7	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
ZMIZ1	7	CTNNB1	30	affinity chromatography technology	Pinnell N (2015)	1
RBPJ	1	SATB1	1	affinity chromatography technology	Li X (2015)	1
ZMIZ1	7	NFATC3	2	affinity chromatography technology	Pinnell N (2015)	1
SIRT1	3	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lin Z (2012), Lin YH (2015), Lin YH (2015), Lin YH (2015)	4
BRCA1	7	TRIM28	1	affinity chromatography technology	Ertych N (2016)	1
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
NOTCH1	25	TRIM28	1	affinity chromatography technology	Yatim A (2012)	1
ZMIZ1	7	BRCA1	7	affinity chromatography technology	Pinnell N (2015)	1
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
ZMIZ1	7	TCF7	1	affinity chromatography technology	Pinnell N (2015)	1
ZMIZ1	7	SMAD4	9	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
ZMIZ1	7	ZEB1	3	affinity chromatography technology	Pinnell N (2015)	1
ZMIZ1	7	AR	3	affinity chromatography technology, two hybrid	Sharma M (2003), Sharma M (2003)	2
ZEB1	3	SMAD3	1	affinity chromatography technology	Postigo AA (2003)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
ZMIZ1	7	MAML1	5	affinity chromatography technology	Pinnell N (2015)	1
MAML1	5	NOTCH1	25	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu L (2000), Wu L (2000), Wu L (2002), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Kim MY (2011), Yatim A (2012), Yatim A (2012), Yatim A (2012), Jeffries S (2002), Kitagawa M (2001)	11
ZMIZ1	7	SMAD3	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2006), Li X (2006), Li X (2006), Li X (2006)	4
SMAD4	9	CTNNB1	30	affinity chromatography technology	Tian YC (2002)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
TRIM28	1	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Doyle JM (2010), Gilmore-Hebert M (2010), Okamoto K (2006)	3
HNRNPL	3	AR	3	affinity chromatography technology	Fei T (2017)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
HNRNPL	3	ZMIZ1	7	affinity chromatography technology	Fei T (2017)	1
RBPJ	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Procopio MG (2015), Procopio MG (2015), Procopio MG (2015)	3
TRIM25	5	TRIM28	1	affinity chromatography technology	Choudhury NR (2017)	1
ZMIZ1	7	TP53	0	two hybrid, pull down, affinity chromatography technology	Lee J (2007), Lee J (2007), Lee J (2007)	3
ZMIZ1	7	ETS1	4	affinity chromatography technology	Pinnell N (2015)	1
NOTCH1	25	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down	Jin YH (2009), Jin YH (2009), Jin YH (2009)	3
SIRT1	3	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fu M (2006), Fu M (2006), Fu M (2006), Fu M (2006)	4
NANOG	0	SMAD4	9	affinity chromatography technology	Oliviero G (2015)	1
TRIM25	5	SMAD4	9	affinity chromatography technology	Choudhury NR (2017)	1
PIAS3	2	SMAD3	1	affinity chromatography technology, pull down	Long J (2004), Long J (2004)	2
BRCA1	7	ETS1	4	pull down	Chai Y (2001)	1
ZMIZ1	7	BCLAF1	5	affinity chromatography technology	Pinnell N (2015)	1
SMAD4	9	AR	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kang HY (2002), Kang HY (2002), Kang HY (2002), Kang HY (2002)	4
CNTNAP2	5	ZMIZ1	7	two hybrid	Nakayama M (2002)	1