PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NAE1	0	UBA3	0	two hybrid, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, biochemical, pull down, biochemical, biochemical, pull down, pull down, biochemical	Chen Y (2000), Chen Y (2000), Huang DT (2008), Huang DT (2007), Walden H (2003), Bohnsack RN (2003), Osaka F (1998), Havugimana PC (2012), Kristensen AR (2012), Huang DT (2004), Gong L (1999), Wan C (2015)	12
CAMK1D	4	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC25A	2	XPO1	8	two hybrid	Wang J (2011)	1
CAMK1D	4	CKS2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK1D	4	TUFM	1	biochemical	Kristensen AR (2012)	1
UBA3	0	PCYT2	0	biochemical	Kristensen AR (2012)	1
CST1	0	CST4	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC25A	2	CUL3	17	two hybrid	Wang J (2011)	1
BAG3	4	HSPA1L	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
TUFM	1	TUBB6	2	biochemical	Kristensen AR (2012)	1
CDH1	4	BAG3	4	bioid	Guo Z (2014)	1
CAMK1D	4	CAMK1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK1D	4	NUCB2	1	biochemical	Kristensen AR (2012)	1
CAMK1D	4	GMFG	1	two hybrid	Wang J (2011)	1
CAMK1D	4	ZG16B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUCB2	1	HSPA1L	2	biochemical	Kristensen AR (2012)	1
CAMK1D	4	APP	1	pull down	Olah J (2011)	1
CAMK1D	4	XYLT2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAE1	0	XPO1	8	biochemical	Kristensen AR (2012)	1
PCYT2	0	XPO1	8	biochemical	Kristensen AR (2012)	1
XPO1	8	NEDD4L	3	affinity chromatography technology	Kirli K (2015)	1
HSPA1L	2	XPO1	8	biochemical	Kristensen AR (2012)	1
APP	1	NAE1	0	pull down, affinity chromatography technology	Chow N (1996), Chow N (1996)	2
PCYT2	0	DCPS	1	biochemical	Kristensen AR (2012)	1
CAMK1D	4	PCYT2	0	biochemical	Kristensen AR (2012)	1
QPCTL	1	APP	1	pull down	Olah J (2011)	1
NAE1	0	DCPS	1	biochemical	Kristensen AR (2012)	1
UBA3	0	DCPS	1	biochemical	Kristensen AR (2012)	1
DCPS	1	XPO1	8	biochemical	Kristensen AR (2012)	1
NUCB2	1	NAE1	0	biochemical	Kristensen AR (2012)	1
BNIP3L	1	CAMK1D	4	two hybrid	Wang J (2011)	1
CAMK1D	4	DCPS	1	biochemical	Kristensen AR (2012)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CDH1	4	CAMK1D	4	bioid	Guo Z (2014)	1
CAMK1D	4	CAMK1G	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAG3	4	CAMK1D	4	affinity chromatography technology	Chen Y (2013)	1
POT1	2	CAMK1D	4	two hybrid	Lee OH (2011)	1
CAMK1D	4	XPO1	8	biochemical	Kristensen AR (2012)	1
CAMK1D	4	MUC7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASAH1	0	CAMK1D	4	two hybrid	Wang J (2011)	1
CAMK1D	4	CALM3	0	affinity chromatography technology	Huttlin EL (2017)	1
NUCB2	1	TUBB6	2	biochemical	Kristensen AR (2012)	1
NAE1	0	PCYT2	0	biochemical	Kristensen AR (2012)	1
NEDD4L	3	CAMK1D	4	enzymatic study	Persaud A (2009)	1
CAMK1D	4	TUBB6	2	biochemical	Kristensen AR (2012)	1
CAMK1D	4	HSPA1L	2	biochemical	Kristensen AR (2012)	1
CAMK1D	4	UBA3	0	biochemical	Kristensen AR (2012)	1
NEDD4	2	CAMK1D	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBA3	0	XPO1	8	biochemical	Kristensen AR (2012)	1
CAMK1D	4	CDC25A	2	two hybrid	Wang J (2011)	1
XPO1	8	TUFM	1	biochemical, biochemical	Kristensen AR (2012), Wan C (2015)	2
CUL3	17	CALM3	0	affinity chromatography technology	Bennett EJ (2010)	1
NUCB2	1	XPO1	8	two hybrid	Wang J (2011)	1
TUFM	1	DCPS	1	biochemical	Kristensen AR (2012)	1
CAMK1D	4	TNFSF13	0	two hybrid	Wang J (2011)	1
LAMP3	1	CAMK1D	4	affinity chromatography technology	Huttlin EL (2017)	1
CAMK1D	4	AMY1C	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK1D	4	QPCTL	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK1D	4	NAE1	0	biochemical	Kristensen AR (2012)	1
CAMK1D	4	CUL3	17	two hybrid	Wang J (2011)	1
CUL3	17	HSPA1L	2	affinity chromatography technology	Bennett EJ (2010)	1
CAMK1D	4	CST4	0	affinity chromatography technology	Huttlin EL (2015)	1
GNRHR	2	CAMK1D	4	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	TUBB6	2	affinity chromatography technology	Bennett EJ (2010)	1
POT1	2	BAG3	4	two hybrid	Lee OH (2011)	1
CDH1	4	ZG16B	0	bioid	Guo Z (2014)	1
CDC25A	2	APP	1	pull down	Olah J (2011)	1
CAMK1	4	APP	1	pull down	Olah J (2011)	1
TUFM	1	NAE1	0	biochemical	Kristensen AR (2012)	1
CUL3	17	TUFM	1	affinity chromatography technology	Bennett EJ (2010)	1
STPG3	1	CAMK1D	4	affinity chromatography technology	Huttlin EL (2017)	1