Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PGLYRP4	rs2916205	CC + CT	Tumor necrosis factor alpha	efficacy	yes	Moderate-to-severe plaque psoriasis. Patients were considered responders if they achieved a 75% improvement over their baseline Psoriasis Area and Severity Index (PASI) (PASI75). PASI data was collected at 3 months, 6 months and 1 year. This variant was significantly associated with response at 3 months. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes CC + CT are associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Psoriasis as compared to genotype TT.	27670765	1448522617