PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPGRIP1	6	IBTK	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	DLG5	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	KIAA1671	0	bioid	Gupta GD (2015)	1
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
IPO9	8	NAP1L1	2	biochemical	Havugimana PC (2012)	1
RPGRIP1	6	SCNM1	0	two hybrid	Rolland T (2014)	1
WDR83	1	GPATCH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
OFD1	3	NAP1L4	3	affinity chromatography technology	Gupta GD (2015)	1
RPGRIP1	6	IPO9	8	bioid	Gupta GD (2015)	1
DPPA4	0	IBTK	3	affinity chromatography technology	Oliviero G (2015)	1
OFD1	3	HAUS8	2	bioid	Gupta GD (2015)	1
RPGRIP1	6	PCM1	5	bioid	Gupta GD (2015)	1
IPO9	8	IPO7	3	biochemical	Wan C (2015)	1
IBTK	3	RPP25L	0	affinity chromatography technology	Hein MY (2015)	1
NPHP4	10	RPP25L	0	affinity chromatography technology	Boldt K (2016)	1
TRIM37	7	SCNM1	0	two hybrid	Rolland T (2014)	1
OFD1	3	SDCCAG3	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP85	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	AEN	0	two hybrid	Rolland T (2014)	1
RPGRIP1	6	NAP1L4	3	bioid	Gupta GD (2015)	1
OFD1	3	IPO5	0	affinity chromatography technology	Gupta GD (2015)	1
BRCA1	7	MAGEB2	0	affinity chromatography technology	Ertych N (2016)	1
HAUS6	5	TFPT	0	affinity chromatography technology	Boldt K (2016)	1
RPGRIP1	6	ADSL	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	ZNF564	4	two hybrid	Rolland T (2014)	1
OFD1	3	COMMD2	1	bioid	Gupta GD (2015)	1
RPGRIP1	6	CBX8	3	two hybrid	Rolland T (2014)	1
RPGRIP1	6	CSPP1	7	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
RPGRIP1	6	NAP1L1	2	bioid	Gupta GD (2015)	1
IPO5	0	IPO7	3	biochemical	Wan C (2015)	1
RPGRIP1	6	WDR83	1	bioid	Gupta GD (2015)	1
RPGRIP1	6	401508	0	two hybrid	Rolland T (2014)	1
NPHP4	10	NEK4	5	affinity chromatography technology	Boldt K (2016)	1
RPGR	0	UNC45A	1	bioid	Gupta GD (2015)	1
PCM1	5	GPATCH1	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	RPP25L	0	two hybrid	Rolland T (2014)	1
RPGRIP1	6	UNC45A	1	bioid	Gupta GD (2015)	1
PCM1	5	HAUS6	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	HSD17B4	0	bioid	Gupta GD (2015)	1
OFD1	3	UNC45A	1	bioid	Gupta GD (2015)	1
RPGRIP1	6	IPO5	0	bioid	Gupta GD (2015)	1
PCM1	5	CCDC22	1	bioid	Gupta GD (2015)	1
IPO5	0	IPO9	8	biochemical	Wan C (2015)	1
HAUS8	2	HAUS6	5	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Uehara R (2009), Uehara R (2009), Uehara R (2009), Uehara R (2009)	4
RPGRIP1	6	CCDC146	3	two hybrid	Rolland T (2014)	1
RPGR	0	NEK4	5	affinity chromatography technology	Boldt K (2016)	1
FEM1C	2	RPGRIP1	6	two hybrid	Rolland T (2014)	1
RPGRIP1	6	COMMD2	1	bioid	Gupta GD (2015)	1
BRCA1	7	IPO7	3	affinity chromatography technology	Ertych N (2016)	1
PCM1	5	HAUS8	2	bioid	Gupta GD (2015)	1
ZNF337	1	RPGRIP1	6	two hybrid	Rolland T (2014)	1
WDR83	1	KIAA1671	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCM1	5	KIF14	8	bioid	Gupta GD (2015)	1
BRCA1	7	GATAD2B	15	affinity chromatography technology	Hill SJ (2014)	1
PTF1A	1	RPGRIP1	6	two hybrid	Hanoun N (2014)	1
IPO8	9	IPO9	8	biochemical	Wan C (2015)	1
OFD1	3	WDR83	1	bioid	Gupta GD (2015)	1
PCM1	5	IFT74	4	bioid	Gupta GD (2015)	1
HEYL	1	RPGRIP1	6	two hybrid	Rolland T (2014)	1
OFD1	3	KIAA1671	0	bioid	Gupta GD (2015)	1
RPGRIP1	6	RBM8A	2	bioid	Gupta GD (2015)	1
OFD1	3	HAUS6	5	bioid	Gupta GD (2015)	1
SDCCAG3	3	TFPT	0	two hybrid	Rolland T (2014)	1
DPPA4	0	RPGRIP1	6	two hybrid	Rolland T (2014)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
RPGRIP1	6	GATAD2B	15	two hybrid	Rolland T (2014)	1
RPGRIP1	6	GPATCH1	3	bioid	Gupta GD (2015)	1
OFD1	3	GPATCH1	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	TNRC6B	10	bioid	Gupta GD (2015)	1
OFD1	3	CCDC22	1	bioid	Gupta GD (2015)	1
RPGRIP1	6	ZNF417	2	two hybrid	Rolland T (2014)	1
IQCE	3	RPGRIP1	6	two hybrid	Corominas R (2014)	1
OFD1	3	TNRC6B	10	bioid	Gupta GD (2015)	1
PCM1	5	IPO5	0	affinity chromatography technology	Gupta GD (2015)	1
RPGRIP1	6	HAUS6	5	bioid	Gupta GD (2015)	1
NAP1L1	2	NAP1L4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	4
RPGRIP1	6	TRIM37	7	bioid	Gupta GD (2015)	1
TRIM37	7	ZNF417	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PCM1	5	CEP131	9	affinity chromatography technology, pull down, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Gupta GD (2015), Gupta GD (2015)	4
OFD1	3	ADSL	5	bioid	Gupta GD (2015)	1
BRCA1	7	NAP1L1	2	affinity chromatography technology	Ertych N (2016)	1
NPHP4	10	RPGRIP1	6	affinity chromatography technology, bioid	Roosing S (2014), Gupta GD (2015)	2
RPGRIP1	6	HAUS8	2	bioid	Gupta GD (2015)	1
PCM1	5	COMMD2	1	bioid	Gupta GD (2015)	1
RPGR	0	RPGRIP1	6	two hybrid, affinity chromatography technology, pull down, two hybrid, bioid, affinity chromatography technology	Roepman R (2000), Roepman R (2000), Roepman R (2000), Rolland T (2014), Gupta GD (2015), Boldt K (2016)	6
RPGRIP1	6	IFT74	4	bioid	Gupta GD (2015)	1
RPGRIP1	6	ECD	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	SDCCAG3	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	NEK4	5	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
BRCA1	7	IPO5	0	affinity chromatography technology	Ertych N (2016)	1
RPGRIP1	6	OFD1	3	bioid	Gupta GD (2015)	1
METTL25	0	RPGRIP1	6	affinity chromatography technology	Boldt K (2016)	1
PCM1	5	TP53BP2	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	IPO7	3	bioid	Gupta GD (2015)	1
RPGRIP1	6	TRIB3	0	two hybrid	Rolland T (2014)	1
TFPT	0	RPGRIP1	6	two hybrid	Rolland T (2014)	1
CCDC22	1	COMMD2	1	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Hein MY (2015), Huttlin EL (2017)	3
TBC1D7	1	RPGRIP1	6	two hybrid	Rolland T (2014)	1
MAGEB2	0	RPGRIP1	6	two hybrid	Rolland T (2014)	1
PCM1	5	SDCCAG3	3	bioid	Gupta GD (2015)	1
CSPP1	7	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
BRCA1	7	TNRC6B	10	affinity chromatography technology	Ertych N (2016)	1
OFD1	3	CSPP1	7	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
RPGRIP1	6	IPO8	9	bioid	Gupta GD (2015)	1
RPGRIP1	6	TP53BP2	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	CEP131	9	bioid	Gupta GD (2015)	1
OFD1	3	TP53BP2	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	ACADSB	1	bioid	Gupta GD (2015)	1
PCM1	5	WDR83	1	bioid	Gupta GD (2015)	1
CEBPA	0	RPGRIP1	6	affinity chromatography technology	Zada AA (2006)	1
RPGRIP1	6	CCDC22	1	bioid	Gupta GD (2015)	1
RPGRIP1	6	CEP85	5	bioid	Gupta GD (2015)	1
OFD1	3	IFT74	4	bioid	Gupta GD (2015)	1
PCM1	5	IBTK	3	bioid	Gupta GD (2015)	1
CHCHD3	0	RPGRIP1	6	two hybrid	Rolland T (2014)	1
OFD1	3	CEP85	5	bioid	Gupta GD (2015)	1
RPGRIP1	6	MKL1	2	bioid	Gupta GD (2015)	1
BRCA1	7	RPGRIP1	6	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
ECD	3	WDR83	1	affinity chromatography technology	Huttlin EL (2017)	1
RPGRIP1	6	KIF14	8	bioid	Gupta GD (2015)	1
RPGR	0	NPHP4	10	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017), Boldt K (2016)	3