PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCTN3	2	RAB1A	0	bioid	Gupta GD (2015)	1
EGFR	5	RAB1A	0	affinity chromatography technology	Yao Z (2017)	1
SARM1	3	IRAK1	1	affinity chromatography technology	Li S (2011)	1
TCTN2	2	RPN1	2	bioid	Gupta GD (2015)	1
TMEM173	0	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TCTN2	2	PTPN1	2	bioid, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017)	2
PHLDA3	0	CCDC47	2	affinity chromatography technology	Ewing RM (2007)	1
NTRK1	1	PYCR1	3	affinity chromatography technology	Emdal KB (2015)	1
RIPK4	0	ILK	0	affinity chromatography technology	Rodriguez J (2016)	1
CYB5B	1	CCDC47	2	biochemical	Wan C (2015)	1
CLN3	2	RPN1	2	affinity chromatography technology	Scifo E (2013)	1
7179	0	AMFR	2	affinity chromatography technology	Yadav L (2017)	1
TCTN2	2	CCDC47	2	bioid	Gupta GD (2015)	1
AMFR	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Jo Y (2011), Pearce MM (2007), Huber MD (2013), Christianson JC (2012)	6
CLN3	2	IRAK1	1	affinity chromatography technology	Behrends C (2010)	1
NTRK1	1	ERLIN2	2	affinity chromatography technology	Emdal KB (2015)	1
TMBIM4	0	CCDC47	2	affinity chromatography technology	Ewing RM (2007)	1
NTRK1	1	CLTC	12	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	RPN1	2	affinity chromatography technology	Bennett EJ (2010)	1
LMNA	2	PHB2	1	affinity chromatography technology	Depreux FF (2015)	1
TMEM67	3	ERLIN2	2	bioid	Gupta GD (2015)	1
NTRK1	1	PHB2	1	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	CTDNEP1	1	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	COPS5	0	affinity chromatography technology	Emdal KB (2015)	1
RPN1	2	CCDC47	2	biochemical	Wan C (2015)	1
TCTN3	2	RPN1	2	bioid	Gupta GD (2015)	1
CCDC47	2	TOM1L1	1	two hybrid	Stelzl U (2005)	1
RIPK4	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
RAB1B	3	CCDC47	2	biochemical	Wan C (2015)	1
CLN3	2	CCDC47	2	affinity chromatography technology	Behrends C (2010)	1
PYCR1	3	CCDC47	2	biochemical	Wan C (2015)	1
EGFR	5	CCDC47	2	affinity chromatography technology	Tong J (2014)	1
CLTC	12	PHB2	1	biochemical	Wan C (2015)	1
TMEM216	0	CCDC47	2	bioid	Gupta GD (2015)	1
EGLN3	0	CCDC47	2	affinity chromatography technology	Rodriguez J (2016)	1
UNC93B1	0	CCDC47	2	affinity chromatography technology	Li S (2011)	1
TMEM237	1	CCDC47	2	bioid	Gupta GD (2015)	1
CLN3	2	ERLIN2	2	affinity chromatography technology	Scifo E (2013)	1
IRF7	2	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRIM25	5	AMFR	2	enzymatic study, pull down	Wang Y (2014), Wang Y (2014)	2
NTRK1	1	RPN1	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	7179	0	two hybrid	Yao Z (2017)	1
AMFR	2	TOM1L1	1	two hybrid	Vinayagam A (2011)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
RAB1B	3	RPN1	2	biochemical	Wan C (2015)	1
ILK	0	CCDC47	2	affinity chromatography technology	So J (2015)	1
TMEM216	0	CYB5B	1	bioid	Gupta GD (2015)	1
LMNA	2	CYB5B	1	two hybrid	Dittmer TA (2014)	1
RIPK4	0	ECT2	2	affinity chromatography technology	Rodriguez J (2016)	1
ECT2	2	PHB2	1	affinity chromatography technology	Woods NT (2012)	1
7179	0	CCDC47	2	bioid	St-Denis N (2016)	1
EVC2	5	PTPN1	2	bioid	Gupta GD (2015)	1
CUL3	17	IRAK1	1	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	IRAK1	1	affinity chromatography technology	Yao Z (2017)	1
RAB1B	3	RAB1A	0	affinity chromatography technology, biochemical, genetic interference, genetic interference, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Blomen VA (2015), Blomen VA (2015), Huttlin EL (2017)	5
CTDNEP1	1	PTPN1	2	bioid	St-Denis N (2016)	1
TIRAP	1	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
EVC2	5	RPN1	2	bioid	Gupta GD (2015)	1
CUL3	17	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	CCDC47	2	affinity chromatography technology	Choudhury NR (2017)	1
COPS5	0	CCDC47	2	affinity chromatography technology	Bennett EJ (2010)	1
AMFR	2	CCDC47	2	affinity chromatography technology	Jo Y (2011)	1
PHB2	1	CCDC47	2	biochemical	Wan C (2015)	1
CUL3	17	CCDC47	2	affinity chromatography technology	Bennett EJ (2010)	1
PTPN1	2	PHB2	1	affinity chromatography technology	Hein MY (2015)	1
TCTN3	2	CCDC47	2	bioid	Gupta GD (2015)	1
EGLN3	0	ILK	0	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
7179	0	RPN1	2	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
EVC2	5	CCDC47	2	bioid	Gupta GD (2015)	1
TIRAP	1	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
EGLN3	0	IRAK1	1	affinity chromatography technology	Rodriguez J (2016)	1
IRAK1	1	LMNA	2	affinity chromatography technology	So J (2015)	1
TOM1L1	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Liu NS (2009), Liu NS (2009)	2
CUL3	17	PYCR1	3	affinity chromatography technology	Bennett EJ (2010)	1
TRIM25	5	ILK	0	affinity chromatography technology	Choudhury NR (2017)	1
TMEM173	0	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
EGFR	5	LMNA	2	affinity chromatography technology	Liccardi G (2014)	1
IRAK1	1	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TMEM17	0	CCDC47	2	bioid	Gupta GD (2015)	1
NTRK1	1	SARM1	3	affinity chromatography technology	Emdal KB (2015)	1
TMEM17	0	TMEM237	1	bioid	Gupta GD (2015)	1
TOM1L1	1	CLTC	12	affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Katoh Y (2006), Liu NS (2009), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007), Collin G (2007)	8
CUL3	17	ILK	0	affinity chromatography technology	Bennett EJ (2010)	1
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
ECT2	2	CCDC47	2	affinity chromatography technology	Woods NT (2012)	1
ERLIN2	2	CCDC47	2	affinity chromatography technology	Jo Y (2011)	1
LMNA	2	CCDC47	2	bioid	Roux KJ (2012)	1
7179	0	PHB2	1	affinity chromatography technology, affinity chromatography technology, bioid	Li X (2016), Yadav L (2017), Yadav L (2017)	3
TCTN3	2	UNC93B1	0	bioid	Gupta GD (2015)	1
EGLN3	0	PTPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
COPS5	0	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
RAB1A	0	CCDC47	2	biochemical	Wan C (2015)	1
TMEM67	3	CCDC47	2	bioid	Gupta GD (2015)	1
TCTN2	2	RAB1A	0	bioid	Gupta GD (2015)	1
NTRK1	1	CCDC47	2	affinity chromatography technology	Emdal KB (2015)	1
COPS5	0	ILK	0	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	RPN1	2	affinity chromatography technology	Rodriguez J (2016)	1
TCTN2	2	TMEM67	3	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	RPN1	2	affinity chromatography technology	Bennett EJ (2010)	1
TCTN3	2	PTPN1	2	bioid	Gupta GD (2015)	1
TMEM216	0	PTPN1	2	bioid	Gupta GD (2015)	1
CLTC	12	CCDC47	2	biochemical	Wan C (2015)	1
NTRK1	1	LMNA	2	affinity chromatography technology	Emdal KB (2015)	1
IRF7	2	IRAK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Li S (2011), Li S (2011), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005)	6
EGFR	5	RPN1	2	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
PTPN1	2	NTRK1	1	unspecified method	Espanel X (2002)	1
RAB1A	0	RPN1	2	biochemical	Wan C (2015)	1
UNC93B1	0	IRAK1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRIM25	5	LMNA	2	affinity chromatography technology	Choudhury NR (2017)	1
CYB5B	1	PHB2	1	biochemical	Wan C (2015)	1
NTRK1	1	AMFR	2	affinity chromatography technology	Emdal KB (2015)	1
ILK	0	RPN1	2	affinity chromatography technology	So J (2015)	1
PTPN1	2	CCDC47	2	affinity chromatography technology	Li X (2016)	1
TCTN3	2	CYB5B	1	bioid	Gupta GD (2015)	1
TMEM17	0	PTPN1	2	bioid	Gupta GD (2015)	1
RIPK4	0	CCDC47	2	affinity chromatography technology	Rodriguez J (2016)	1
CTDNEP1	1	CCDC47	2	bioid	St-Denis N (2016)	1
EGLN3	0	ECT2	2	affinity chromatography technology	Rodriguez J (2016)	1
ILK	0	LMNA	2	affinity chromatography technology	So J (2015)	1
CLTC	12	RPN1	2	biochemical	Wan C (2015)	1
SARM1	3	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TMEM67	3	RPN1	2	bioid	Gupta GD (2015)	1
ECT2	2	RPN1	2	affinity chromatography technology	Woods NT (2012)	1