PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
MSH3	4	OTUD7B	3	biochemical	Havugimana PC (2012)	1
OTUD7B	3	NUP155	2	affinity chromatography technology	Sowa ME (2009)	1
OTUD7B	3	EGFR	5	affinity chromatography technology	Pareja F (2011)	1
HIF1A	1	OTUD7B	3	affinity chromatography technology	Bremm A (2014)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
PARK7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2010), Zucchelli S (2010)	2
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
XPO1	8	MLST8	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	HIF1AN	0	affinity chromatography technology	Kirli K (2015)	1
PARK7	0	OTUD7B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McNally RS (2011), McNally RS (2011), McNally RS (2011)	3
OTUD7B	3	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Rodriguez J (2016)	3
AGO1	11	OTUD7B	3	affinity chromatography technology	Zhang L (2015)	1
LGR4	3	UBC	7	affinity chromatography technology	Carmon KS (2014)	1
OTUD7B	3	AURKA	1	enzymatic study	Min M (2015)	1
TRAF6	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Sun H (2013), Sun H (2013), Sun H (2013), Rezaeian AH (2017), Rezaeian AH (2017)	5
OTUD7B	3	ACAD9	1	affinity chromatography technology	Sowa ME (2009)	1
HIF1A	1	WWOX	3	affinity chromatography technology	Maroni P (2014)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
UBC	7	AGO1	11	affinity chromatography technology	Matsumoto M (2005)	1
OTUD7B	3	XPO1	8	imaging technique	Garcia-Santisteban I (2012)	1
EGFR	5	UBE2S	2	affinity chromatography technology	Tong J (2014)	1
LGR4	3	OTUD7B	3	affinity chromatography technology	Carmon KS (2014)	1
OTUD7B	3	MLST8	1	affinity chromatography technology, affinity chromatography technology	Wang B (2017), Wang B (2017)	2
WWOX	3	OTUD7B	3	affinity chromatography technology	Abu-Odeh M (2014)	1
XPO1	8	AURKA	1	affinity chromatography technology	Kirli K (2015)	1
WWP2	7	OTUD7B	3	affinity chromatography technology	Chaudhary N (2014)	1
UBC	7	OTUD7B	3	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down	Pareja F (2011), Bremm A (2010), Mevissen TE (2013), Michel MA (2015), Kristariyanto YA (2015), Castaneda CA (2016), Mevissen TE (2016), Mevissen TE (2016), Kwasna D (2018)	9
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
TRAF6	0	OTUD7B	3	affinity chromatography technology	Evans PC (2001)	1
OTUD7B	3	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
OTUD7B	3	SLC9A3R2	8	affinity chromatography technology	Sowa ME (2009)	1
HIF1AN	0	HIF1A	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Mahon PC (2001), Mahon PC (2001), Mahon PC (2001), Luo W (2010), Liu YV (2007), Lee YM (2009), Lee YM (2009), Lee YM (2009), Hewitson KS (2002), Li SH (2008), Sakamoto T (2009), Rodriguez J (2016)	12
ZDHHC17	1	OTUD7B	3	two hybrid	Butland SL (2014)	1
PIK3R3	0	OTUD7B	3	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
HIF1A	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1