PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANKS1B	2	APP	1	pull down	Olah J (2011)	1
ANKS1B	2	EPHA8	4	affinity chromatography technology	Kim J (2010)	1
ERBB2	6	ANKS1B	2	unspecified method	Jones RB (2006)	1
LRP1	25	ANKS1B	2	two hybrid	Kajiwara Y (2010)	1
LRP1	25	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
LRP2	13	ANKS1B	2	two hybrid	Petersen HH (2003)	1
ANKS1B	2	UBC	7	two hybrid, pull down	Kim J (2010), Kim J (2010)	2
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
RIN1	1	ANKS1B	2	two hybrid	Grossmann A (2015)	1
ERBB4	5	ANKS1B	2	unspecified method	Jones RB (2006)	1
EGFR	5	RIN1	1	affinity chromatography technology	Kong C (2007)	1
EGFR	5	ANKS1B	2	unspecified method	Jones RB (2006)	1
EGFR	5	LRP1	25	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Yao Z (2017)	3
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ERBB2	6	RIN1	1	unspecified method	Jones RB (2006)	1