PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HLTF	7	UBC	7	enzymatic study	Masuda Y (2012)	1
XPO1	8	RPL10A	0	affinity chromatography technology	Kirli K (2015)	1
PIP4K2A	0	SRRM2	18	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	DBF4	2	two hybrid	Woods NT (2012)	1
NBN	1	UBE2A	0	affinity chromatography technology	Yanagihara H (2011)	1
USP2	0	PCNA	0	enzymatic study	Masuda Y (2012)	1
TRIM23	3	RAD18	3	two hybrid	Woodsmith J (2012)	1
BRCA1	7	RPL10A	0	affinity chromatography technology	Ertych N (2016)	1
CDC5L	2	UBE2M	0	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	WRNIP1	3	affinity chromatography technology	Lleres D (2010)	1
RAD18	3	RFC2	0	enzymatic study	Tomida J (2008)	1
RAD18	3	TNPO3	16	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	UBE2I	0	fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, affinity chromatography technology	Morris JR (2009), Morris JR (2009), Xu J (2009), Xu J (2009)	4
SMC6	3	TP53BP1	3	affinity chromatography technology	Hein MY (2015)	1
BATF3	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD18	3	DBF4	2	affinity chromatography technology, affinity chromatography technology	Yamada M (2013), Yamada M (2013)	2
SNW1	0	SRRM2	18	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	ECT2	2	affinity chromatography technology	Lleres D (2010)	1
SRP9	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	RAD18	3	two hybrid	Markson G (2009)	1
UBE2I	0	PSME3	0	enzymatic study	Wu Y (2011)	1
SNW1	0	MLKL	1	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	HLTF	7	affinity chromatography technology	Lleres D (2010)	1
RAD51	3	UBE2I	0	two hybrid, two hybrid	Kovalenko OV (1996), Shen Z (1996)	2
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
RAD18	3	ORC2	0	biochemical	Centore RC (2012)	1
CDC7	2	RAD18	3	enzymatic study, affinity chromatography technology	Day TA (2010), Day TA (2010)	2
FANCD2	3	RAD51	3	affinity chromatography technology, biochemical, imaging technique, pull down	Chen X (2016), Chen X (2016), Sato K (2016), Sato K (2016)	4
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
POLH	1	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Qian J (2014), Qian J (2014), Qian J (2014), Qian J (2014), Qian J (2014)	5
HLTF	7	SHPRH	7	affinity chromatography technology	Lin JR (2011)	1
SNW1	0	CDC5L	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010)	4
RAD18	3	SRGAP1	3	affinity chromatography technology	Hein MY (2015)	1
BATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
XPO1	8	RPS2	3	affinity chromatography technology	Kirli K (2015)	1
POLH	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
ZFP41	0	RAD18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD18	3	HIST1H2AA	1	affinity chromatography technology	Inagaki A (2011)	1
USP7	14	HLTF	7	affinity chromatography technology	Sowa ME (2009)	1
RAD18	3	SLF2	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
UBE2A	0	UBE2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong JH (2015), Hong JH (2015), Huttlin EL (2017)	3
BRCA1	7	RFC2	0	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Hill SJ (2014)	2
ZNF263	2	ZMYM2	5	affinity chromatography technology	Huttlin EL (2017)	1
FANCD2	3	NBN	1	affinity chromatography technology	Nakanishi K (2002)	1
UBE2A	0	SLF1	2	affinity chromatography technology	Hong JH (2015)	1
ZMYM2	5	UBE2B	3	two hybrid, affinity chromatography technology	Kunapuli P (2003), Kunapuli P (2003)	2
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
SMC6	3	SLF2	3	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	ARRB2	5	affinity chromatography technology	Kirli K (2015)	1
SPRTN	0	HLTF	7	affinity chromatography technology	Ghosal G (2012)	1
XPO1	8	DBF4	2	affinity chromatography technology	Kirli K (2015)	1
RAD18	3	SPRTN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012)	4
FANCD2	3	POLN	4	imaging technique, affinity chromatography technology	Park HK (2010), Moldovan GL (2010)	2
TAX1BP1	3	RAD18	3	two hybrid	Rolland T (2014)	1
RPS2	3	RAD18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLH	1	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Yuasa MS (2006), Yuasa MS (2006)	2
SMC6	3	RAD18	3	affinity chromatography technology	Hein MY (2015)	1
POLK	0	RAD18	3	affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Lin JR (2011), Lin JR (2011)	3
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
CDC5L	2	FANCD2	3	affinity chromatography technology	Lleres D (2010)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
BRCA1	7	RPS2	3	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	RAD51	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scully R (1997), Dong Y (2003), Dong Y (2003), Dong Y (2003), Wang Q (2001), Chen J (1998), Mok MT (2010), Scully R (1997), Scully R (1997), Johnson N (2013), Jung YS (2014), Jung YS (2014), Parameswaran B (2015)	13
LLGL2	4	RAD18	3	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
UBC	7	RFC2	0	affinity chromatography technology	Matsumoto M (2005)	1
BRCA1	7	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian F (2013), Tian F (2013), Hill SJ (2014)	3
ZNF692	3	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	SIVA1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang J (2011), Han J (2014), Han J (2014), Han J (2014), Han J (2014), Han J (2014), Han J (2014), Hein MY (2015)	8
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
RAD51	3	FANCI	1	pull down	Sato K (2016)	1
PCGF6	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
TP53BP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Matsuoka S (2007), Wang B (2002), Bohgaki T (2011), Ertych N (2016)	4
MAPK8	3	JUNB	0	affinity chromatography technology	Fuchs SY (1997)	1
ATF2	1	MAPK8	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study	Raingeaud J (1995), Fuchs SY (1997), Chen Z (2001), Tournier C (1997), Pipaon C (2004), Pipaon C (2004), Pillai VB (2011), Jensen LE (2003), Jensen LE (2003), Deacon K (1997), Bustelo XR (1997), Gupta S (1996), Yao K (2007), Li H (2001), Sanna MG (2002)	15
UBE2B	3	PCNA	0	enzymatic study, enzymatic study	Masuda Y (2010), Watanabe K (2004)	2
TP53BP1	3	RFC2	0	affinity chromatography technology	Woods NT (2012)	1
TP53BP1	3	UBE2I	0	imaging technique	Galanty Y (2009)	1
MLKL	1	RAD18	3	two hybrid	Wang J (2011)	1
NBN	1	ATF2	1	affinity chromatography technology, imaging technique	Bhoumik A (2005), Bhoumik A (2005)	2
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
RAD51	3	RAD18	3	affinity chromatography technology, pull down, affinity chromatography technology	Huang J (2009), Huang J (2009), Chen X (2016)	3
UBE2I	0	MAP3K1	4	two hybrid, pull down, affinity chromatography technology	Saltzman A (1998), Saltzman A (1998), Kubota Y (2011)	3
CREM	1	UBE2I	0	two hybrid	Wang J (2011)	1
POLH	1	RAD18	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yuasa MS (2006), Yuasa MS (2006), Day TA (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Lin JR (2011), Durando M (2013)	8
SLF2	3	SLF1	2	affinity chromatography technology	Hein MY (2015)	1
RAD18	3	SIVA1	0	affinity chromatography technology, affinity chromatography technology, pull down	Han J (2014), Han J (2014), Han J (2014)	3
DZIP3	6	RAD18	3	two hybrid	Woodsmith J (2012)	1
SHPRH	7	UBE2A	0	affinity chromatography technology	Unk I (2006)	1
RAD18	3	LIN7C	0	affinity chromatography technology	Hein MY (2015)	1
RAD18	3	SLF1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Liu T (2011), Liu T (2011), Liu T (2011), Hein MY (2015)	4
XPO1	8	LIN7C	0	affinity chromatography technology	Kirli K (2015)	1
USP2	0	PCGF6	0	two hybrid	Hayes SD (2012)	1
SNW1	0	RFC2	0	affinity chromatography technology	Lleres D (2010)	1
USP5	2	PCNA	0	biochemical	Kristensen AR (2012)	1
LLGL2	4	UBE2A	0	affinity chromatography technology	Huttlin EL (2017)	1
USP2	0	RAD18	3	enzymatic study	Zeman MK (2014)	1
HLTF	7	RAD18	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Unk I (2008), Unk I (2008), Lin JR (2011), Lin JR (2011), Lin JR (2011), Sertic S (2013), Zeman MK (2014)	7
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
FANCD2	3	RAD18	3	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, biochemical	Williams SA (2011), Williams SA (2011), Park HK (2010), Chen X (2016), Chen X (2016)	5
DTL	0	HLTF	7	affinity chromatography technology, affinity chromatography technology	Sertic S (2013), Sertic S (2013)	2
RAD18	3	UBE2A	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Xin H (2000), Xin H (2000), Tateishi S (2000), Tateishi S (2000), Markson G (2009), Inagaki A (2011), Watanabe K (2004), Masuda Y (2012), Masuda Y (2012), Masuda Y (2012), Watson NB (2008), Miyase S (2005), Barkley LR (2012), Unk I (2006), Kumar R (2014), Kumar R (2014), Zeman MK (2014), Masuda Y (2012), Hong JH (2015), Hein MY (2015), Hein MY (2015), Masuda Y (2015)	22
SMC6	3	SLF1	2	affinity chromatography technology	Hein MY (2015)	1
RAD18	3	USP5	2	affinity chromatography technology, affinity chromatography technology	Nakajima S (2014), Nakajima S (2014)	2
RHNO1	1	RAD18	3	affinity chromatography technology, affinity chromatography technology	Cotta-Ramusino C (2011), Cotta-Ramusino C (2011)	2
RAD18	3	TP53BP1	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Watanabe K (2009), Watanabe K (2009), Watanabe K (2009), Watanabe K (2009)	4
RAD18	3	CAVIN1	0	affinity chromatography technology	Hein MY (2015)	1
USP7	14	TRIM8	6	two hybrid, two hybrid	Hayes SD (2012), Wang J (2011)	2
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
JPH4	4	UBE2A	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	RAD18	3	enzymatic study	Charlaftis N (2014)	1
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
USP2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
PCNA	0	RFC2	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai J (1997), Pan ZQ (1993), Ohta S (2002), Han J (2014), Hein MY (2015)	5
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
UBE2I	0	DTL	0	affinity chromatography technology	Hein MY (2015)	1
SNW1	0	RAD18	3	affinity chromatography technology	Lleres D (2010)	1
RAD18	3	PCGF6	0	two hybrid	Woodsmith J (2012)	1
UBC	7	PSME3	0	affinity chromatography technology	Matsumoto M (2005)	1
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
PSME3	0	RAD18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD18	3	RPL10A	0	biochemical	Havugimana PC (2012)	1
TULP3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
SNW1	0	FANCI	1	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	UBE2M	0	affinity chromatography technology	Lleres D (2010)	1
SHPRH	7	PCNA	0	enzymatic study	Unk I (2006)	1
LLGL2	4	ATF2	1	affinity chromatography technology	Hein MY (2015)	1
SPRTN	0	POLH	1	affinity chromatography technology, affinity chromatography technology	Ghosal G (2012), Ghosal G (2012)	2
BATF3	0	ATF2	1	fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Huttlin EL (2017)	2
TXNIP	2	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
PCNA	0	RAD51	3	affinity chromatography technology, imaging technique	Chen X (2016), Sato K (2016)	2
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
ITSN1	5	TRIM8	6	two hybrid	Wong KA (2012)	1
PSME3	0	PCGF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD18	3	NBN	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yanagihara H (2011), Yanagihara H (2011), Yanagihara H (2011), Yanagihara H (2011)	4
SRRM2	18	CDC5L	2	affinity chromatography technology, biochemical	McCracken S (2005), Havugimana PC (2012)	2
HLTF	7	UBE2A	0	enzymatic study	Masuda Y (2012)	1
CDC5L	2	HLTF	7	affinity chromatography technology	Lleres D (2010)	1
JPH4	4	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
ORC2	0	DBF4	2	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003)	3
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
UBE2I	0	TRIM23	3	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
BRCA1	7	PSME3	0	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	NBN	1	biochemical, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Shimada M (2009), Chen L (2008), Hill SJ (2014), Goldstein M (2015), Goldstein M (2015), Parameswaran B (2015)	9
CERK	4	HLTF	7	affinity chromatography technology	Hein MY (2015)	1
RAD18	3	SRGAP3	8	affinity chromatography technology	Hein MY (2015)	1
ATF2	1	PCNA	0	affinity chromatography technology	Lau E (2012)	1
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
ATF2	1	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	POLK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bi X (2006), Ogi T (2010), Ogi T (2010), Jones MJ (2011), Boehm EM (2016)	5
XPO1	8	RAD18	3	affinity chromatography technology	Kirli K (2015)	1
ZMYM2	5	RAD18	3	affinity chromatography technology	Kunapuli P (2003)	1
RAD18	3	UBE2M	0	affinity chromatography technology	Guan J (2017)	1
POLN	4	RAD51	3	affinity chromatography technology	Moldovan GL (2010)	1
UBC	7	RAD18	3	affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down	Matsumoto M (2005), Fenner BJ (2009), Bish RA (2007), Rizzo AA (2014), Rizzo AA (2014), Shereda RD (2010), Shereda RD (2010), Panier S (2012), Ali AM (2012), Thach TT (2015)	10
CDC5L	2	RAD18	3	affinity chromatography technology	Lleres D (2010)	1
LLGL2	4	MAP3K1	4	affinity chromatography technology	Hein MY (2015)	1
TSG101	1	ITSN1	5	two hybrid	Amit I (2004)	1
MAPK8	3	RAD18	3	enzymatic study	Barkley LR (2012)	1
ECT2	2	RFC2	0	affinity chromatography technology	Woods NT (2012)	1
XPO1	8	WRNIP1	3	affinity chromatography technology	Kirli K (2015)	1
BRCA1	7	USP7	14	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
USP2	0	TRIM23	3	two hybrid	Hayes SD (2012)	1
NBN	1	UBE2B	3	affinity chromatography technology	Yanagihara H (2011)	1
RPL10A	0	RPS2	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SRRM2	18	RAD18	3	affinity chromatography technology	McCracken S (2005)	1
TCEANC2	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
ECT2	2	RAD18	3	affinity chromatography technology	Woods NT (2012)	1
RAD18	3	PCNA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Song IY (2010), Inagaki A (2011), Kobayashi J (2010), Masuda Y (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Notenboom V (2007), Notenboom V (2007), Wong RP (2011), Masuda Y (2012), Unk I (2006), Tomida J (2008), Durando M (2013), Han J (2014), Han J (2014), Han J (2014), Masuda Y (2012), Masuda Y (2015), Guan J (2017)	20
JUNB	0	BRCA1	7	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu YF (2002), Hu YF (2002), Hu YF (2002), Kang HJ (2008), Hill SJ (2014), Huttlin EL (2017)	6
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
DTL	0	RAD18	3	affinity chromatography technology	Sertic S (2013)	1
ZMYM2	5	UBE2A	0	two hybrid, affinity chromatography technology	Kunapuli P (2003), Kunapuli P (2003)	2
PCNA	0	WRNIP1	3	pull down	Kanu N (2016)	1
POLH	1	PCNA	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology	Haracska L (2001), Haracska L (2001), Kannouche PL (2004), Bienko M (2010), Bienko M (2010), Bienko M (2010), Bienko M (2010), Jung YS (2011), Zlatanou A (2011), Plosky BS (2006), Vidal AE (2004), Sekimoto T (2010), Hibbert RG (2012), Mosbech A (2012), Durando M (2013), Qin Z (2013), Fu D (2013), Fu D (2013), Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010), Ahmed-Seghir S (2015), Inoue A (2014), Hedglin M (2016), Hedglin M (2016), Dai X (2016), Guan J (2017)	27
SNW1	0	ORC2	0	affinity chromatography technology	Lleres D (2010)	1
DTL	0	SHPRH	7	affinity chromatography technology	Sertic S (2013)	1
JUNB	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
USP7	14	RAD18	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Zlatanou A (2016), Zlatanou A (2016), Zlatanou A (2016), Zlatanou A (2016)	4
ZNF263	2	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD18	3	RAD18	3	pull down, x-ray crystallography, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Lin JR (2011), Huang A (2011), Miyase S (2005), Kumar R (2014), Zeman MK (2014), Zeman MK (2014), Miyase S (2005)	7
IRF9	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
SRRM2	18	RPS2	3	affinity chromatography technology	McCracken S (2005)	1
UBE2A	0	PCNA	0	enzymatic study	Unk I (2006)	1
UBE2A	0	RPL10A	0	affinity chromatography technology	An H (2017)	1
UBC	7	CAVIN1	0	pull down	Zhang X (2017)	1
HLTF	7	PCNA	0	affinity chromatography technology, enzymatic study, enzymatic study	Unk I (2008), Masuda Y (2012), Achar YJ (2015)	3
TULP3	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	SRRM2	18	affinity chromatography technology	Xiao K (2007)	1
TSG101	1	TRIM23	3	two hybrid	Markson G (2009)	1
XPO1	8	KLHDC3	1	affinity chromatography technology	Kirli K (2015)	1
TSG101	1	UBE2I	0	biochemical	Wan C (2015)	1
RAD18	3	UBE2B	3	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Xin H (2000), Xin H (2000), Tateishi S (2000), Tateishi S (2000), Markson G (2009), Hibbert RG (2011), Inagaki A (2011), Watanabe K (2004), Huang A (2011), Huang A (2011), Huang A (2011), Notenboom V (2007), Notenboom V (2007), Song IY (2010), Tomida J (2008), Masuda Y (2010), Han J (2014), Hong JH (2015), Huttlin EL (2017), Foglizzo M (2016)	20
CERK	4	RAD18	3	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	RFC2	0	affinity chromatography technology	Lleres D (2010)	1
POLK	0	RAD51	3	affinity chromatography technology	Hein MY (2015)	1
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
DZIP3	6	CAVIN1	0	affinity chromatography technology	Boldt K (2016)	1
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
TSG101	1	TAX1BP1	3	two hybrid	Rolland T (2014)	1
SNW1	0	NBN	1	affinity chromatography technology	Lleres D (2010)	1
UBE2B	3	SLF1	2	affinity chromatography technology	Hong JH (2015)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
RAD18	3	FANCI	1	imaging technique	Williams SA (2011)	1
UBE2I	0	ZMYM2	5	two hybrid	Bandyopadhyay S (2010)	1
RAD18	3	CPD	4	imaging technique	Ghosal G (2012)	1
ATF2	1	UBE2I	0	two hybrid, far western blotting	Firestein R (1998), Firestein R (1998)	2
RAD18	3	CREM	1	affinity chromatography technology	Hein MY (2015)	1
UBE2I	0	DZIP3	6	two hybrid	Markson G (2009)	1
ZNF501	2	RAD18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ORC2	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Matsuoka S (2007), Hill SJ (2014)	2
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
RAD18	3	ATPAF1	0	affinity chromatography technology	Hein MY (2015)	1
PIP4K2A	0	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
POLN	4	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, imaging technique	Moldovan GL (2010), Bi X (2006), Barkley LR (2012), Park JM (2014), Park JM (2014)	5
TSG101	1	XPO1	8	biochemical, affinity chromatography technology	Havugimana PC (2012), Kirli K (2015)	2
POLN	4	RAD18	3	affinity chromatography technology, affinity chromatography technology	Bi X (2006), Barkley LR (2012)	2
UBE2I	0	RAD18	3	two hybrid	Markson G (2009)	1
POLN	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takata K (2015), Takata K (2015), Takata K (2015)	3
XPO1	8	CDC7	2	affinity chromatography technology	Kirli K (2015)	1
MAGEA4	0	RAD18	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHDC3	1	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD18	3	TRIM8	6	two hybrid	Woodsmith J (2012)	1
RAD18	3	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Yoshimura A (2009), Yoshimura A (2009)	2
CDC5L	2	NBN	1	affinity chromatography technology	Lleres D (2010)	1
UBE2A	0	TAX1BP1	3	affinity chromatography technology	Hein MY (2015)	1
FANCD2	3	POLH	1	affinity chromatography technology, affinity chromatography technology, biochemical	Fu D (2013), Fu D (2013), Fu D (2013)	3
HLTF	7	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
BRCA1	7	CDC5L	2	affinity chromatography technology	Ertych N (2016)	1
RAD18	3	ITSN1	5	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	RAD18	3	affinity chromatography technology	Huttlin EL (2017)	1
TP53BP1	3	UBC	7	affinity chromatography technology	Benada J (2015)	1
RAD18	3	HK2	3	affinity chromatography technology	Hein MY (2015)	1
POLN	4	FANCI	1	affinity chromatography technology	Moldovan GL (2010)	1
TSG101	1	DZIP3	6	two hybrid	Markson G (2009)	1
RAD18	3	SHPRH	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Lin JR (2011), Lin JR (2011), Unk I (2006), Zeman MK (2014), Zeman MK (2014), Zeman MK (2014)	6
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
CDC5L	2	FANCI	1	affinity chromatography technology	Lleres D (2010)	1