PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM21	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBTD1	0	UBE2D3	1	two hybrid, biochemical, affinity chromatography technology	Uhler JP (2013), Uhler JP (2013), Uhler JP (2013)	3
UBE2D4	0	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
USP5	2	APP	1	pull down	Olah J (2011)	1
UBE2W	0	TRIM17	5	two hybrid	Markson G (2009)	1
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
USP2	0	MNAT1	0	two hybrid	Hayes SD (2012)	1
ZNF331	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM39	0	MOAP1	0	affinity chromatography technology, affinity chromatography technology, biochemical	Lee SS (2009), Lee SS (2009), Lee SS (2009)	3
KDM1A	2	PSMD9	0	affinity chromatography technology	Boldt K (2016)	1
USP39	1	TRIM8	6	two hybrid	Hayes SD (2012)	1
ZNF669	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM39	0	SMCO3	0	two hybrid	Rolland T (2014)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
USP2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
ZNF621	0	CBX5	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E1	1	RNF166	0	two hybrid	Markson G (2009)	1
MNAT1	0	TRIM21	0	two hybrid	Woodsmith J (2012)	1
UBE2L3	1	TRIM39	0	two hybrid	Markson G (2009)	1
UBE2D3	1	RNF166	0	two hybrid	Markson G (2009)	1
TRIM39	0	UBXN6	1	two hybrid	Rolland T (2014)	1
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
UBE2D2	0	RNF166	0	two hybrid	Markson G (2009)	1
ZNF311	3	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
PLCD4	6	APP	1	pull down	Olah J (2011)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
ZIM2	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMD9	0	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM39	0	UBTD2	2	two hybrid	Rolland T (2014)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
OTUB2	0	APP	1	pull down	Olah J (2011)	1
TP53	0	TRIM8	6	affinity chromatography technology	Caratozzolo MF (2012)	1
PSMA6	1	TRIM39	0	two hybrid	Rolland T (2014)	1
ZNF816	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E1	1	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
UBAC1	2	APP	1	pull down	Olah J (2011)	1
KRAS	1	UBE2D1	0	genetic interference	Luo J (2009)	1
CBX5	3	ZNF764	2	affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Huttlin EL (2017)	2
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
LNX1	7	UBE2D2	0	pull down, pull down, pull down	Nie J (2002), Nie J (2004), Guo Z (2012)	3
ZNF223	1	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
UBAC1	2	TRIM39	0	two hybrid	Rolland T (2014)	1
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
TRIM39	0	LXN	0	two hybrid	Rolland T (2014)	1
TRIM39	0	CACTIN	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Suzuki M (2016), Suzuki M (2016), Suzuki M (2016), Suzuki M (2016)	4
UBC	7	PSMA6	1	affinity chromatography technology	Matsumoto M (2005)	1
TRIM39	0	TTC32	0	two hybrid	Rolland T (2014)	1
TRIM39	0	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
USP39	1	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2E2	1	APP	1	pull down	Olah J (2011)	1
ZNF707	2	TRIM39	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	POLI	5	affinity chromatography technology, imaging technique	Hampp S (2016), Hampp S (2016)	2
CCNC	0	TRIM39	0	two hybrid	Rolland T (2014)	1
KRAS	1	PRPF3	3	genetic interference	Vizeacoumar FJ (2013)	1
POLI	5	UBC	7	two hybrid, two hybrid, far western blotting, x-ray crystallography, pull down, far western blotting	Plosky BS (2006), Plosky BS (2006), McIntyre J (2012), Bomar MG (2010), Plosky BS (2006), McIntyre J (2012)	6
CDKN1A	1	UBE2D1	0	two hybrid	Vinayagam A (2011)	1
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
EIF4A2	4	TRIM39	0	two hybrid	Rolland T (2014)	1
UBC	7	UBAC1	2	pull down	Zhang X (2017)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
TRIM21	0	TRIM39	0	two hybrid, two hybrid	Woodsmith J (2012), Rolland T (2014)	2
UBE2D3	1	TRIM17	5	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
POLI	5	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
ZNF562	1	TRIM39	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRPF3	3	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2K	0	TRIM39	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM39	0	TRIM39	0	two hybrid, affinity chromatography technology, enzymatic study, two hybrid, two hybrid, two hybrid	Rual JF (2005), Rual JF (2005), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
LMNA	2	TRIM39	0	two hybrid	Dittmer TA (2014)	1
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
UBE2D2	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
MED18	0	CCNC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UBTD1	0	UBE2D2	0	two hybrid, biochemical	Uhler JP (2013), Uhler JP (2013)	2
ZNF354C	3	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	TRIM39	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
WDFY3	17	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM17	5	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
UBE2W	0	TRIM8	6	two hybrid	Markson G (2009)	1
USP2	0	RNF166	0	two hybrid	Hayes SD (2012)	1
ZNF419	1	TRIM39	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
UBTD2	2	UBC	7	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Song AX (2010), Song AX (2010), Song AX (2014), Song AX (2014)	4
KRAS	1	APP	1	pull down	Olah J (2011)	1
USP2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
LMNA	2	USP2	0	two hybrid	Dittmer TA (2014)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
LMNA	2	ZNF490	1	two hybrid	Dittmer TA (2014)	1
UBE2E2	1	RNF166	0	two hybrid	Markson G (2009)	1
OTUB2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
KDM1A	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Tsai WW (2008), Tsai WW (2008), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007)	7
TRIM39	0	LNX1	7	two hybrid	Rolland T (2014)	1
EPHB6	4	TRIM39	0	two hybrid	Rolland T (2014)	1
ZNF556	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	TRIM17	5	two hybrid	Markson G (2009)	1
OTUD6A	2	TRIM39	0	two hybrid	Hayes SD (2012)	1
UBE2E3	0	RNF166	0	two hybrid	Markson G (2009)	1
MNAT1	0	TRIM17	5	two hybrid	Woodsmith J (2012)	1
UBXN1	0	TRIM39	0	two hybrid	Rolland T (2014)	1
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
CBX5	3	ZNF324B	1	affinity chromatography technology	Nozawa RS (2010)	1
UBTD1	0	UBE2D1	0	biochemical	Uhler JP (2013)	1
UBE2D1	0	TRIM17	5	two hybrid, two hybrid, pull down	Markson G (2009), Napolitano LM (2011), Woodsmith J (2012)	3
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
USP39	1	TRIM39	0	two hybrid	Hayes SD (2012)	1
CBX5	3	ZNF264	2	affinity chromatography technology	Nozawa RS (2010)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
TRIM39	0	UBE2N	1	pull down	Woodsmith J (2012)	1
TRIM39	0	CBX3	1	affinity chromatography technology	Chaturvedi P (2012)	1
USP39	1	PRPF3	3	affinity chromatography technology	Sowa ME (2009)	1
OTUB2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
PDLIM5	0	TRIM39	0	two hybrid	Rual JF (2005)	1
USP5	2	TRIM39	0	two hybrid	Hayes SD (2012)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
ZNF264	2	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
TRIM39	0	CBX1	0	affinity chromatography technology	Chaturvedi P (2012)	1
UBTD1	0	UBE2D4	0	two hybrid	Uhler JP (2013)	1
ZNF324B	1	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
OTUD6A	2	UBC	7	enzymatic study	Mevissen TE (2013)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
ZNF19	0	TRIM39	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
ZNF26	0	TRIM39	0	two hybrid	Rolland T (2014)	1
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
TP53	0	MNAT1	0	pull down, affinity chromatography technology	Ko LJ (1997), Ko LJ (1997)	2
POLI	5	APP	1	pull down	Olah J (2011)	1
TRIM39	0	KDM1A	2	two hybrid, two hybrid, two hybrid	Weimann M (2013), Rolland T (2014), Yu H (2011)	3
TRIM21	0	UBE2L3	1	pull down	Wada K (2006)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2D4	0	RNF166	0	two hybrid	Markson G (2009)	1
ZNF621	0	TRIM39	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP2	0	TRIM21	0	two hybrid	Hayes SD (2012)	1
ZNF416	0	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
HINFP	0	TP53	0	two hybrid	Yu H (2011)	1
TRIM17	5	UBE2N	1	pull down	Woodsmith J (2012)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRIM39	0	CDKN1A	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2012), Zhang L (2012)	2
UBE2V1	0	TRIM8	6	two hybrid	Markson G (2009)	1
HINFP	0	TRIM39	0	two hybrid	Yu H (2011)	1
USP39	1	APP	1	pull down	Olah J (2011)	1
KRAS	1	TRIM39	0	genetic interference	Luo J (2009)	1
DIP2A	12	TRIM39	0	two hybrid	Rolland T (2014)	1
ZNF354C	3	CBX5	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM39	0	APP	1	pull down	Olah J (2011)	1
UBE2E3	0	TRIM39	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2E2	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
TRIM39	0	CBX5	3	affinity chromatography technology	Chaturvedi P (2012)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ZNF562	1	CBX5	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RECK	6	TRIM39	0	two hybrid	Rolland T (2014)	1
UBTD2	2	USP5	2	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	Song AX (2014), Song AX (2014), Song AX (2014), Song AX (2014), Song AX (2014)	5
TRIM39	0	UBTD1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
MNAT1	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
ZNF490	1	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	RNF166	0	two hybrid	Markson G (2009)	1
MED18	0	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM39	0	PLCD4	6	two hybrid	Rual JF (2005)	1
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
TRIM39	0	ZKSCAN4	1	two hybrid	Rolland T (2014)	1
UBXN6	1	APP	1	pull down	Olah J (2011)	1
ZNF214	1	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF764	2	TRIM39	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	TRIM39	0	two hybrid	Markson G (2009)	1
TRIM17	5	UBC	7	enzymatic study	Woodsmith J (2012)	1
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
LXN	0	ZKSCAN4	1	two hybrid	Rolland T (2014)	1
UBE2V1	0	TRIM39	0	two hybrid	Markson G (2009)	1
UBE2W	0	RNF166	0	two hybrid	Markson G (2009)	1
KRAS	1	ZNF764	2	genetic interference	Vizeacoumar FJ (2013)	1