PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSEN2	3	CIB1	2	two hybrid, pull down, genetic interference, affinity chromatography technology	Stabler SM (1999), Stabler SM (1999), Stabler SM (1999), Stabler SM (1999)	4
PSEN2	3	PDCD4	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	APH1A	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004), Sato T (2007), Kuo LH (2008)	10
PSEN2	3	FLNB	11	two hybrid, pull down	Zhang W (1998), Zhang W (1998)	2
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
PSEN2	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
FAF2	4	ACTG1	5	affinity chromatography technology	Christianson JC (2012)	1
PSEN2	3	KCNIP4	0	two hybrid, affinity chromatography technology	Morohashi Y (2002), Morohashi Y (2002)	2
PSEN2	3	CHKA	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	APBA1	6	affinity chromatography technology	Biederer T (2002)	1
GFAP	0	APP	1	pull down	Olah J (2011)	1
IFIT3	1	IFIT5	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Pichlmair A (2011)	2
ECSIT	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Crystal AS (2003), Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	6
PSEN2	3	CAPN1	3	two hybrid, affinity chromatography technology	Shinozaki K (1998), Shinozaki K (1998)	2
MAST1	9	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PPP5C	2	PSEN2	3	affinity chromatography technology	Hein MY (2015)	1
MAST1	9	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
NCSTN	1	APP	1	affinity chromatography technology	Yu G (2000)	1
PSEN2	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
FHL2	0	TRAF6	0	affinity chromatography technology, enzymatic study	Bai S (2008), Bai S (2008)	2
APP	1	IFIT3	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
TSPAN5	0	APP	1	pull down	Olah J (2011)	1
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	APBA3	2	affinity chromatography technology	Biederer T (2002)	1
EXOC6	1	APP	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
PSEN2	3	ICAM5	0	pull down	Annaert WG (2001)	1
FAF2	4	DNAJB1	1	affinity chromatography technology	Christianson JC (2012)	1
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN2	3	HPS1	1	two hybrid	Soler-Lopez M (2011)	1
TSPAN5	0	PSEN2	3	affinity chromatography technology	Huttlin EL (2015)	1
ECSIT	3	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	APH1A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PSEN1	11	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	MGEA5	3	two hybrid	Soler-Lopez M (2011)	1
APH1B	0	NCSTN	1	affinity chromatography technology	Hebert SS (2004)	1
APBA2	1	APBA1	6	affinity chromatography technology	Huttlin EL (2017)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
FAF2	4	EVI5L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	RNF115	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ECSIT	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	LIPF	0	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	NPLOC4	4	affinity chromatography technology	Huttlin EL (2017)	1
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
NCSTN	1	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee SF (2002), Yu G (2000), Hebert SS (2004)	3
APP	1	APBA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Araki Y (2003), Araki Y (2003), Biederer T (2002), Biederer T (2002), Tomita S (1999), Tomita S (1999)	6
FAF2	4	PSEN2	3	affinity chromatography technology	Huttlin EL (2015)	1
NOS3	7	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
ERGIC3	5	PSEN2	3	affinity chromatography technology	Huttlin EL (2015)	1
PSEN2	3	AAMP	3	two hybrid	Soler-Lopez M (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN2	3	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
KCNIP4	0	APP	1	pull down	Olah J (2011)	1
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
APH1B	0	PSENEN	3	affinity chromatography technology	Hebert SS (2004)	1
FAF2	4	GCDH	2	affinity chromatography technology	Raman M (2015)	1
PSEN2	3	ACTG1	5	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	ICAM5	0	affinity chromatography technology, two hybrid, pull down	Annaert WG (2001), Annaert WG (2001), Annaert WG (2001)	3
NCSTN	1	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Yu G (2000), Hebert SS (2004), Sato T (2007), Sato T (2007), Kuo LH (2008)	11
FAF2	4	ECSIT	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSEN1	11	BCL2L1	0	two hybrid	Passer BJ (1999)	1
PSEN2	3	ECD	3	two hybrid	Soler-Lopez M (2011)	1
ELAVL1	0	PDCD4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NCSTN	1	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Steiner H (2002), Yonemura Y (2011), Kuo LH (2008)	5
TRAF6	0	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elzinga BM (2009), Yan R (2013), Yan R (2013)	3
SPC24	0	APP	1	pull down	Olah J (2011)	1
KCNIP3	1	PSEN1	11	affinity chromatography technology, affinity chromatography technology	Buxbaum JD (1998), Kashiwa A (2000)	2
KIF22	1	PSEN2	3	affinity chromatography technology	Hein MY (2015)	1
APH1B	0	PSEN2	3	affinity chromatography technology	Hebert SS (2004)	1
FBXL12	1	CAPN1	3	affinity chromatography technology	Nishiyama M (2015)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
TRAF6	0	IFIT3	1	affinity chromatography technology	Liu XY (2011)	1
PPP5C	2	APP	1	pull down	Olah J (2011)	1
APP	1	APBA1	6	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Biederer T (2002), Biederer T (2002), Borg JP (1996), Borg JP (1996), Borg JP (1996)	5
PSEN2	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	DYNC1H1	41	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NOS3	7	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
FHL2	0	APP	1	pull down	Olah J (2011)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
APH1A	2	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004)	4
PSEN2	3	APBA2	1	affinity chromatography technology	Biederer T (2002)	1
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN2	3	EID1	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	EVI5L	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
ART3	1	PSEN2	3	affinity chromatography technology	Huttlin EL (2015)	1
PSEN1	11	PDCD4	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
DNAJB1	1	APP	1	pull down	Olah J (2011)	1
NCSTN	1	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), LaVoie MJ (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Lee SF (2002), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Kuo LH (2008), Kuo LH (2008)	14
ELAVL1	0	MGEA5	3	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF115	1	APP	1	pull down	Olah J (2011)	1
PSEN2	3	CLK1	1	affinity chromatography technology	Hein MY (2015)	1
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	GFAP	0	two hybrid, pull down	Nielsen AL (2002), Nielsen AL (2002)	2
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
MAST1	9	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
UBQLN1	1	PSEN1	11	two hybrid, pull down, fluorescent resonance energy transfe, pull down	Mah AL (2000), Mah AL (2000), Thomas AV (2006), Ford DL (2006)	4
UBQLN1	1	PSEN2	3	two hybrid, pull down, two hybrid, pull down, pull down	Mah AL (2000), Mah AL (2000), Ford DL (2007), Ford DL (2007), Ford DL (2006)	5
CHKA	1	APP	1	pull down	Olah J (2011)	1
PSEN2	3	CEP55	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
CAPN1	3	FHL2	0	two hybrid	Jiang LQ (2002)	1
PSEN2	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	SPC24	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
APP	1	APBA3	2	affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology	Biederer T (2002), Biederer T (2002), Tanahashi H (1999), Tanahashi H (1999), Huttlin EL (2017)	5
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	RNF115	1	affinity chromatography technology	Huttlin EL (2017)	1
PSENEN	3	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Kimberly WT (2003), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Yonemura Y (2011), Kuo LH (2008)	8
PSEN1	11	KCNIP4	0	two hybrid	Morohashi Y (2002)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
PSENEN	3	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	3
PSEN1	11	FLNB	11	two hybrid, pull down	Zhang W (1998), Zhang W (1998)	2
MAST1	9	IFIT5	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	BCL2L1	0	two hybrid, affinity chromatography technology	Passer BJ (1999), Passer BJ (1999)	2
PSEN2	3	GFAP	0	two hybrid	Nielsen AL (2002)	1
ELAVL1	0	NPLOC4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
PSEN2	3	FHL2	0	two hybrid, affinity chromatography technology	Tanahashi H (2000), Tanahashi H (2000)	2
AAMP	3	PDCD4	2	biochemical	Kristensen AR (2012)	1
ELAVL1	0	NCSTN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NOS3	7	ELAVL1	0	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	PSEN2	3	affinity chromatography technology	Hebert SS (2004)	1
PSEN2	3	SRI	1	affinity chromatography technology	Pack-Chung E (2000)	1
PSEN2	3	KCNIP3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buxbaum JD (1998), Choi EK (2001), Buxbaum JD (1998), Buxbaum JD (1998)	4
APH1B	0	PSEN1	11	affinity chromatography technology	Hebert SS (2004)	1
ELAVL1	0	IFIT5	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PSEN1	11	CIB1	2	two hybrid	Stabler SM (1999)	1
PSEN1	11	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
DLK1	2	PSEN2	3	affinity chromatography technology	Huttlin EL (2015)	1