PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPA1	1	PRMT8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	3
DHX9	3	ALYREF	0	biochemical	Wan C (2015)	1
PRMT8	2	TAF15	2	enzymatic study	Lee J (2005)	1
DHX9	3	HNRNPR	3	biochemical	Wan C (2015)	1
FBXW11	2	DHX9	3	affinity chromatography technology	Kim TY (2014)	1
PRMT8	2	LSM14A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COIL	1	PRMT1	3	two hybrid	Lim J (2006)	1
PRMT8	2	PRMT1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lee J (2005), Weimann M (2013), Weimann M (2013), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	7
266553	0	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT8	2	CHTOP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRMT8	2	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EWSR1	2	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
HNRNPK	4	HNRNPU	12	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PRMT8	2	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPU	12	FAM120A	3	affinity chromatography technology	Hein MY (2015)	1
SERBP1	2	PRMT8	2	two hybrid	Weimann M (2013)	1
HNRNPU	12	HNRNPA1	1	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Roy R (2014), Hein MY (2015), Hein MY (2015)	5
HNRNPK	4	PRMT1	3	affinity chromatography technology, enzymatic study	Cote J (2003), Wada K (2002)	2
CEP162	3	PRMT1	3	two hybrid	Weimann M (2013)	1
VIM	0	INA	2	affinity chromatography technology	Huttlin EL (2017)	1
EWSR1	2	ALYREF	0	bioid	Elzi DJ (2014)	1
PRMT8	2	PRMT8	2	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Lee J (2005), Weimann M (2013), Rolland T (2014)	5
CEP162	3	PRMT8	2	two hybrid	Weimann M (2013)	1
PRMT1	3	DHX9	3	affinity chromatography technology, pull down	Smith WA (2004), Smith WA (2004)	2
FBXW11	2	THRAP3	2	affinity chromatography technology	Low TY (2014)	1
SYNCRIP	6	LSM14A	0	biochemical	Havugimana PC (2012)	1
HNRNPR	3	SERBP1	2	biochemical	Wan C (2015)	1
ZNF451	3	PRMT8	2	two hybrid	Weimann M (2013)	1
FBXW11	2	HNRNPUL2	2	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Huttlin EL (2017)	2
PRMT1	3	VIM	0	affinity chromatography technology	Boldt K (2016)	1
HNRNPK	4	DHX9	3	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
PRMT8	2	ANGEL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DHX9	3	HNRNPU	12	affinity chromatography technology, biochemical, affinity chromatography technology	Chu L (2012), Kristensen AR (2012), Hein MY (2015)	3
PRMT1	3	HNRNPA1	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Lin WJ (1996), Jeronimo C (2007), Robin-Lespinasse Y (2007), Chan JY (2009), Chan JY (2009), Chan JY (2009), Roy R (2014)	7
HNRNPA1	1	ALYREF	0	affinity chromatography technology	Close P (2012)	1
PRMT1	3	CHTOP	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Takai H (2014), Takai H (2014), Takai H (2014)	3
DHX9	3	EWSR1	2	pull down, affinity chromatography technology, affinity chromatography technology	Toretsky JA (2006), Toretsky JA (2006), Elzi DJ (2014)	3
PRMT1	3	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Naeem H (2007), Rizzo G (2005), Wang H (2001), Shia WJ (2012), Rezai-Zadeh N (2003)	5
COIL	1	PRMT8	2	two hybrid	Lim J (2006)	1
FBXW11	2	DCAF8	1	affinity chromatography technology	Low TY (2014)	1
PRMT8	2	BCLAF1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPU	12	HNRNPR	3	affinity chromatography technology	Hein MY (2015)	1
HNRNPA1	1	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Close P (2012), Roy R (2014)	2
HNRNPA1	1	HNRNPR	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Huttlin EL (2015), Roy R (2014), Hein MY (2015), Huttlin EL (2017)	7
SYNCRIP	6	FAM120A	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
BCLAF1	5	THRAP3	2	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
PRMT1	3	TAF15	2	enzymatic study, affinity chromatography technology	Wada K (2002), Huttlin EL (2017)	2
HNRNPA1	1	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Hein MY (2015)	4
PRMT8	2	FAM120A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCLAF1	5	ALYREF	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPU	12	SYNCRIP	6	two hybrid, two hybrid, biochemical, biochemical, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
SPDEF	2	PRMT8	2	affinity chromatography technology	Huttlin EL (2017)	1
PRMT8	2	ALYREF	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DHX9	3	THRAP3	2	biochemical	Havugimana PC (2012)	1
PRMT8	2	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPA1	1	HNRNPK	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Close P (2012), Havugimana PC (2012), Roy R (2014), Hein MY (2015)	5
FBXW11	2	HNRNPU	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	4
VHL	0	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PRMT1	3	SYNCRIP	6	enzymatic study, affinity chromatography technology, two hybrid	Wada K (2002), Weimann M (2013), Weimann M (2013)	3
PRMT8	2	NEFM	0	affinity chromatography technology	Huttlin EL (2015)	1
ZNF451	3	PRMT1	3	two hybrid	Weimann M (2013)	1
VHL	0	HNRNPU	12	affinity chromatography technology	Lai Y (2011)	1
ZSCAN1	2	PRMT8	2	affinity chromatography technology	Huttlin EL (2017)	1
BCLAF1	5	PRMT1	3	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	HNRNPR	3	affinity chromatography technology	Coyaud E (2015)	1
BCLAF1	5	CHTOP	3	affinity chromatography technology	Hein MY (2015)	1
HNRNPK	4	HNRNPR	3	biochemical	Havugimana PC (2012)	1
VIM	0	NEFM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
PRMT8	2	DHX9	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPA1	1	HNRNPUL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Roy R (2014), Hein MY (2015)	3
VHL	0	HNRNPA1	1	affinity chromatography technology	Lai Y (2011)	1
SYNCRIP	6	ANGEL2	1	affinity chromatography technology	Huttlin EL (2017)	1
SYNCRIP	6	PRMT8	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Venkatesan K (2009), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	5
PPARA	1	PRMT8	2	two hybrid	Weimann M (2013)	1
PRMT1	3	HNRNPU	12	enzymatic study	Lee J (2002)	1
PRMT8	2	SCAF11	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VHL	0	PRMT8	2	two hybrid	Weimann M (2013)	1
PRMT8	2	HNRNPR	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEFM	0	INA	2	affinity chromatography technology	Huttlin EL (2017)	1
SYNCRIP	6	HNRNPR	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
VHL	0	HNRNPK	4	affinity chromatography technology	Lai Y (2011)	1
HNRNPA1	1	FAM120A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Roy R (2014), Hein MY (2015), Huttlin EL (2017)	4
HNRNPA1	1	DHX9	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Close P (2012), Kristensen AR (2012), Roy R (2014), Hein MY (2015)	4
PRMT8	2	THRAP3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPU	12	LSM14A	0	biochemical	Havugimana PC (2012)	1
FBXW11	2	FAM120A	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
PRMT8	2	VIM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPA1	1	TAF15	2	affinity chromatography technology	Hein MY (2015)	1
HNRNPK	4	SYNCRIP	6	biochemical, two hybrid, two hybrid	Havugimana PC (2012), Hegele A (2012), Hegele A (2012)	3
HNRNPU	12	SERBP1	2	affinity chromatography technology	Hein MY (2015)	1
VHL	0	HNRNPR	3	affinity chromatography technology	Lai Y (2011)	1
DCAF8	1	PRMT8	2	two hybrid	Weimann M (2013)	1
PRMT8	2	INA	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRMT8	2	HNRNPK	4	affinity chromatography technology	Huttlin EL (2017)	1
GPATCH2L	1	PRMT8	2	two hybrid	Weimann M (2013)	1
HNRNPU	12	THRAP3	2	biochemical	Havugimana PC (2012)	1
SERBP1	2	VIM	0	two hybrid	Stelzl U (2005)	1
PPARA	1	PRMT1	3	two hybrid	Weimann M (2013)	1
GIMAP2	0	PRMT8	2	affinity chromatography technology	Huttlin EL (2017)	1
PRMT8	2	HNRNPUL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRMT8	2	HIST1H4A	0	enzymatic study	Lee J (2005)	1
TIGD7	2	PRMT8	2	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPU	12	ALYREF	0	affinity chromatography technology	Hein MY (2015)	1
PRMT1	3	HNRNPR	3	enzymatic study, two hybrid, two hybrid	Wada K (2002), Stelzl U (2005), Rolland T (2014)	3
GPATCH2L	1	PRMT1	3	two hybrid	Weimann M (2013)	1
PRMT8	2	PRRC2C	9	affinity chromatography technology	Huttlin EL (2015)	1
DCAF8	1	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
FBXW11	2	SYNCRIP	6	affinity chromatography technology	Coyaud E (2015)	1
FBXW11	2	HNRNPA1	1	affinity chromatography technology	Coyaud E (2015)	1
HNRNPA1	1	ANGEL2	1	affinity chromatography technology	Roy R (2014)	1
266553	0	PRMT8	2	two hybrid	Weimann M (2013)	1