PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
RPS6KA5	2	APP	1	pull down	Olah J (2011)	1
PTPN7	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
MKNK1	0	APP	1	pull down	Olah J (2011)	1
BAG3	4	MAPK11	1	affinity chromatography technology	Chen Y (2013)	1
MAPK11	1	MAPKAPK3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
MAPK14	0	HDAC3	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	3
PTPN7	3	APP	1	pull down	Olah J (2011)	1
MAPKAPK3	0	MAPK14	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Tanoue T (2001), Tanoue T (2001), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Vogl T (2004), Huttlin EL (2017)	10
MAPK14	0	MKNK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	7
MAPKAPK3	0	APP	1	pull down	Olah J (2011)	1
MAPK14	0	HDAC1	4	biochemical	Wan C (2015)	1
PML	7	MAPK11	1	affinity chromatography technology, pull down	Shin J (2004), Shin J (2004)	2
PML	7	ATF2	1	pull down	Vallian S (1998)	1
MAPK11	1	SH2D1A	0	enzymatic study	Stein B (1997)	1
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
MAPK14	0	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Varjosalo M (2013), Huttlin EL (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Camps M (1998)	6
ATF2	1	APP	1	pull down	Olah J (2011)	1
MAPK11	1	HDAC3	5	two hybrid, far western blotting, pull down	Mahlknecht U (2004), Mahlknecht U (2004), Mahlknecht U (2004)	3
CUL7	4	APP	1	affinity chromatography technology	Hanson D (2014)	1
PTPRR	3	MAPKAPK3	0	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MAPK14	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Varjosalo M (2013)	2
MAPK11	1	HDAC1	4	biochemical	Wan C (2015)	1
TAB1	1	POLR3D	0	two hybrid	Vinayagam A (2011)	1
PML	7	HDAC3	5	affinity chromatography technology, pull down	Wu WS (2001), Wu WS (2001)	2
MAPK11	1	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), St-Denis N (2016), Li X (2016)	3
MAPK11	1	CCND1	1	enzymatic study	Casanovas O (2000)	1
TAB1	1	C9orf78	0	two hybrid	Vinayagam A (2011)	1
RPS6KA5	2	MBP	0	enzymatic study	New L (1999)	1
MAPK11	1	ATF2	1	enzymatic study, enzymatic study	Stein B (1997), Takahashi M (2003)	2
MAPK14	0	PPM1G	1	biochemical	Wan C (2015)	1
MAPK11	1	CUL7	4	affinity chromatography technology	Varjosalo M (2013)	1
MAPK11	1	VARS	5	affinity chromatography technology	Varjosalo M (2013)	1
TAB1	1	MAPK14	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Ge B (2002), Ge B (2002), Vinayagam A (2011), Ge B (2003), Chen TC (2014), Grimsey NJ (2015)	6
CCDC8	1	VARS	5	affinity chromatography technology	Hanson D (2014)	1
MAPK14	0	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
RPS6KA5	2	MAPK11	1	genetic interference	Deak M (1998)	1
RPS6KA5	2	ATF2	1	imaging technique	Chen TC (2014)	1
MAPK11	1	MAPKAPK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Janknecht R (2001), Janknecht R (2001)	3
MAPK11	1	MAPT	1	enzymatic study	Goedert M (1997)	1
PTPN7	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
MAPK11	1	MKNK1	0	affinity chromatography technology	Varjosalo M (2013)	1
MAPK11	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
MAPK11	1	C9orf78	0	two hybrid	Vinayagam A (2011)	1
MAPK14	0	RPS6KA5	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	5
HTRA2	1	MAPK14	0	two hybrid, affinity chromatography technology, enzymatic study	Faccio L (2000), Faccio L (2000), Plun-Favreau H (2007)	3
CCND1	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Petre-Draviam CE (2005), Lin HM (2002), Fu M (2005), Fu M (2005), Batra S (2010)	5
MAPK11	1	APP	1	pull down	Olah J (2011)	1
MAPK11	1	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
MAPK14	0	ATF2	1	enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Raingeaud J (1995), Raingeaud J (1995), Chen Z (2001), Pillai VB (2011), Pillai VB (2011), Gianni M (2006), Deacon K (1997), Sudo T (2000), Mo JS (2010), Uddin S (2002), Stein B (1997), Yuan ZQ (2003), Coxon PY (2003), Li H (2001), Sun L (2007), Grimsey NJ (2015), Tang J (2008), Dixon DA (2006), Chen G (2000), Frantz B (1998), Tesker M (2016), Hwang SG (2014), Camps M (1998), Bakin AV (2002), Bulavin DV (1999)	25
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
C9orf78	0	APP	1	pull down	Olah J (2011)	1
MAPK11	1	SOCS3	0	two hybrid	Vinayagam A (2011)	1
MAPK11	1	CPNE6	1	two hybrid	Vinayagam A (2011)	1
MAPK14	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
PKN1	4	PPM1G	1	biochemical	Wan C (2015)	1
MAPK14	0	SH2D1A	0	enzymatic study	Stein B (1997)	1
PTPRR	3	MAPK11	1	affinity chromatography technology	Li X (2016)	1
MAPK11	1	PPM1G	1	biochemical	Wan C (2015)	1
DUSP2	0	MAPK11	1	affinity chromatography technology	Li X (2016)	1
PTPN7	3	MAPK14	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
PKN1	4	MAPT	1	enzymatic study	Taniguchi T (2001)	1
PKN1	4	MBP	0	enzymatic study	Isagawa T (2005)	1
MAPK14	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
ATF2	1	CCND1	1	pull down	Lee RJ (1999)	1
OBSL1	9	CCDC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2011), Hanson D (2011), Hanson D (2014), Nie J (2015)	4
SOCS3	0	APP	1	pull down	Olah J (2011)	1
MAPK11	1	TAB1	1	imaging technique	Chen TC (2014)	1
MAPK11	1	POLR3D	0	two hybrid	Vinayagam A (2011)	1
MAPK11	1	ARHGAP12	2	affinity chromatography technology	Varjosalo M (2013)	1
MAPK11	1	OBSL1	9	affinity chromatography technology	Varjosalo M (2013)	1
DUSP2	0	MAPK14	0	affinity chromatography technology	Li X (2016)	1
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3
CCDC8	1	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hanson D (2014), Nie J (2015), Nie J (2015)	3
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
MAPK11	1	CCDC8	1	affinity chromatography technology	Varjosalo M (2013)	1
CCND1	1	CUL7	4	affinity chromatography technology	Okabe H (2007)	1
PKN1	4	MAPK11	1	affinity chromatography technology	Takahashi M (2003)	1
RPS6KA5	2	MAPT	1	enzymatic study	Virdee K (2007)	1
APP	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1