PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBL2	5	LIN54	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2009)	5
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
LIN9	3	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
EWSR1	2	MYBL2	2	bioid	Elzi DJ (2014)	1
XPO1	8	LIN9	3	affinity chromatography technology	Kirli K (2015)	1
CDK2	0	LIN37	0	affinity chromatography technology	So J (2015)	1
FOXM1	3	LIN37	0	affinity chromatography technology	Li X (2015)	1
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
RBL2	5	LIN52	1	affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007)	2
LIN54	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2009), Rashid NN (2014)	6
LIN37	0	LZTS2	4	two hybrid	Rolland T (2014)	1
KRT31	0	CEP70	1	two hybrid	Rolland T (2014)	1
LIN9	3	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Huttlin EL (2017)	5
LIN54	1	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
LIN37	0	SCGB1D2	0	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	LIN37	0	two hybrid	Rolland T (2014)	1
PNMA1	0	LIN37	0	two hybrid	Rolland T (2014)	1
FOXM1	3	MYBL2	2	affinity chromatography technology	Li X (2015)	1
LIN9	3	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
LIN52	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Hauri S (2016)	2
LIN9	3	MYBL1	0	affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Huttlin EL (2017)	2
KRT31	0	LIN37	0	two hybrid	Rolland T (2014)	1
MYBL2	2	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Hauri S (2016)	2
RBL1	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Joaquin M (2003), Joaquin M (2002), Joaquin M (2002), Schmit F (2007)	4
LIN9	3	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
LIN54	1	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
LIN52	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Schmit F (2007)	2
LIN37	0	PYGB	3	affinity chromatography technology	Huttlin EL (2015)	1
LIN54	1	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
LIN37	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
CDR2	1	KIFC3	3	two hybrid	Rolland T (2014)	1
LIN9	3	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	4
LIN54	1	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2017)	7
LIN37	0	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
LIN54	1	MYBL1	0	affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Huttlin EL (2017)	2
KIFC3	3	TRIM54	1	two hybrid	Rolland T (2014)	1
E2F4	0	XPO1	8	affinity chromatography technology, unspecified method	Ohtani N (2003), Xu D (2012)	2
RBL1	1	TFDP1	3	affinity chromatography technology	Wu CL (1995)	1
LIN54	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Schmit F (2007), Hauri S (2016)	3
MYBL1	0	LIN52	1	affinity chromatography technology	Huttlin EL (2017)	1
E2F4	0	TFDP2	1	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng N (1999), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	4
CDK2	0	TFDP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dynlacht BD (1997), Dynlacht BD (1997), So J (2015)	3
XPO1	8	LIN37	0	affinity chromatography technology	Kirli K (2015)	1
RBL1	1	TFDP2	1	affinity chromatography technology	Wu CL (1995)	1
RBBP4	3	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007), Huttlin EL (2017), Hauri S (2016)	4
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
RBL2	5	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
FOXM1	3	LIN54	1	affinity chromatography technology	Li X (2015)	1
LIN37	0	TEX11	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
CDK2	0	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Luescher-Firzlaff JM (2006)	2
LIN37	0	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
RBL2	5	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	5
RBL2	5	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
LIN37	0	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
XPO1	8	TUBB3	3	affinity chromatography technology	Kirli K (2015)	1
LIN37	0	KRT40	0	two hybrid	Rolland T (2014)	1
RBL2	5	RBBP4	3	affinity chromatography technology	Litovchick L (2007)	1
LIN54	1	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
LIN37	0	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	6
RBL2	5	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
LIN37	0	MYBL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Huttlin EL (2015), Huttlin EL (2017)	3
LIN37	0	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	7
LIN54	1	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
XPO1	8	LZTS2	4	affinity chromatography technology	Kirli K (2015)	1
FOXM1	3	LIN9	3	affinity chromatography technology	Li X (2015)	1
LIN54	1	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
TFDP1	3	E2F4	0	two hybrid, pull down, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Sardet C (1995), Dynlacht BD (1997), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998), Hauri S (2016)	6
LIN37	0	HSPA4	3	affinity chromatography technology	Schmit F (2007)	1
LIN37	0	CEP70	1	two hybrid	Rolland T (2014)	1
E2F4	0	RBL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iavarone A (1999), Litovchick L (2007), Schmit F (2007), Kong LJ (2006), Farkas T (2002), Osterloh L (2007), Yakovlev VA (2013), Martin N (2012), Martin N (2012)	9
LIN9	3	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
4105	0	LIN37	0	two hybrid	Rolland T (2014)	1
TFIP11	5	LIN37	0	two hybrid	Rolland T (2014)	1
CDK2	0	RBL2	5	enzymatic study, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Lacy S (1997), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Howard CM (2000), Huttlin EL (2017)	9
CDK2	0	HSPA4	3	affinity chromatography technology	Neganova I (2011)	1
CDK2	0	MYBL2	2	enzymatic study, enzymatic study, enzymatic study	Mueller-Tidow C (2001), Bartsch O (1999), Johnson TK (1999)	3
KIFC3	3	KRT31	0	two hybrid	Rolland T (2014)	1
KIFC3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
LIN37	0	TUBB3	3	affinity chromatography technology	Schmit F (2007)	1
LIN9	3	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Osterloh L (2007), Osterloh L (2007), Yamauchi T (2008), Rashid NN (2014), Huttlin EL (2017)	9
LIN37	0	TRIM54	1	two hybrid	Rolland T (2014)	1
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
CDR2	1	LIN37	0	two hybrid	Rolland T (2014)	1
LIN37	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007)	2
KIFC3	3	KRT40	0	two hybrid	Rolland T (2014)	1
EWSR1	2	LIN37	0	bioid	Elzi DJ (2014)	1