PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VDR	2	CREBBP	29	imaging technique, pull down	Saramaeki A (2006), Jimenez-Lara AM (1999)	2
SRC	2	GAB2	3	affinity chromatography technology	Zhao C (1999)	1
TP53	0	IFI16	1	affinity chromatography technology	Johnstone RW (2000)	1
MAPK3	4	PTPRE	1	affinity chromatography technology	Toledano-Katchalski H (2003)	1
ATF2	1	ATP5B	0	affinity chromatography technology	Lau E (2012)	1
MAPK3	4	MYOG	1	two hybrid	Corominas R (2014)	1
HDAC4	10	HNF4A	2	pull down	Torres-Padilla ME (2002)	1
MAPK3	4	BTBD10	4	two hybrid	Vinayagam A (2011)	1
LYN	2	CREBBP	29	pull down	Whiting RJ (2012)	1
VCP	6	DUSP9	0	affinity chromatography technology	Yu CC (2013)	1
DUSP6	2	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muda M (1998), Muda M (1998), Xie XL (2015), Xie XL (2015), St-Denis N (2016), Li X (2016)	6
ARRB1	2	MAPK14	0	affinity chromatography technology	McLaughlin NJ (2006)	1
IRS1	7	UBTF	8	affinity chromatography technology, affinity chromatography technology	Sun H (2003), Dalmizrak O (2007)	2
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
MAPK3	4	GMFB	0	affinity chromatography technology, affinity chromatography technology	Zaheer A (1996), Zaheer A (1996)	2
ATP1A1	9	VDAC1	2	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
MAPK3	4	PFN1	0	affinity chromatography technology	Hein MY (2015)	1
CSTF1	1	NMD3	2	biochemical	Wan C (2015)	1
SRC	2	IQGAP1	1	affinity chromatography technology	Meyer RD (2008)	1
MKNK1	0	PAK2	0	imaging technique	Chen TC (2014)	1
VCP	6	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fogeron ML (2013), Itoh N (2017), Itoh N (2017), Itoh N (2017)	4
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
TP53	0	USO1	1	affinity chromatography technology	How PC (2011)	1
MCM2	3	MAP3K1	4	affinity chromatography technology	Drissi R (2015)	1
MAPK1	1	PFKM	4	biochemical	Wan C (2015)	1
SNCG	0	MAPK1	1	affinity chromatography technology	Pan ZZ (2002)	1
PNKD	2	MAPK3	4	affinity chromatography technology	Huttlin EL (2015)	1
MAPK3	4	DHPS	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Corominas R (2014), So J (2015), Hein MY (2015)	4
SRC	2	MAPK3	4	affinity chromatography technology	Lee J (2013)	1
TP53BP1	3	CDC23	3	affinity chromatography technology	Woods NT (2012)	1
MCM2	3	MAPK1	1	affinity chromatography technology	Drissi R (2015)	1
TP53	0	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPK3	4	PAK2	0	biochemical	Wan C (2015)	1
CREBBP	29	ELK1	2	far western blotting	Janknecht R (1996)	1
ATF7IP	5	PML	7	imaging technique	Sasai N (2013)	1
MAPK1	1	ELK1	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Eblen ST (2003), Cano E (1995), Cano E (1995), Himpel S (2000), Han S (2010), Zhang X (2011), Basaki Y (2002), Iwata A (2001), Corbit KC (2003), Zhu Z (2005), Bourguignon LY (2005), Ahmed N (2002), Janknecht R (1997), Cavigelli M (1995), Tapinos N (2005), Eliopoulos AG (2006), Ho DT (2003), Kendrick TS (2004)	18
ATF2	1	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Rong Y (2010), Rong Y (2010)	2
ASNS	0	UBA1	1	biochemical	Wan C (2015)	1
GALE	0	ASNS	0	biochemical	Wan C (2015)	1
DCUN1D1	0	GALE	0	biochemical	Wan C (2015)	1
MAPK3	4	PTGS2	0	affinity chromatography technology	Lin C (2011)	1
TULP3	0	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
HADH	1	FKBP2	0	biochemical	Wan C (2015)	1
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
ARRB2	5	FASN	15	affinity chromatography technology	Xiao K (2007)	1
BRCA1	7	GEMIN5	1	affinity chromatography technology	Ertych N (2016)	1
HDAC4	10	CIITA	4	affinity chromatography technology, affinity chromatography technology	Wang AH (2005), Wang AH (2005)	2
MAPK1	1	ATP1A1	9	enzymatic study	Al-Khalili L (2004)	1
SP1	0	HNF4A	2	affinity chromatography technology, affinity chromatography technology, pull down	Wang HY (2009), Wang HY (2009), Magenheim J (2005)	3
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
PPP2CA	7	DAPK1	6	enzymatic study, affinity chromatography technology	Widau RC (2010), Guenebeaud C (2010)	2
SREBF1	5	SREBF2	5	fluorescent resonance energy transfe	Zoumi A (2005)	1
ARRB1	2	MAP3K1	4	affinity chromatography technology	Xiao K (2007)	1
VCP	6	RAF1	3	affinity chromatography technology	Yu CC (2013)	1
VTA1	1	MAPK3	4	biochemical	Wan C (2015)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
RPTOR	4	IRS1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tzatsos A (2006), Tzatsos A (2009), Tzatsos A (2009), Tzatsos A (2009)	4
MAPK3	4	L3MBTL3	0	two hybrid	Corominas R (2014)	1
CAV1	0	MAPK1	1	affinity chromatography technology	Hua H (2003)	1
SRC	2	RPS6KA3	2	enzymatic study	Kang S (2008)	1
RPS6KA2	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), So J (2015)	4
MAPK3	4	TRIM54	1	two hybrid	Corominas R (2014)	1
CSTF2T	4	SYMPK	3	affinity chromatography technology	Huttlin EL (2017)	1
ID2	0	PHF3	8	affinity chromatography technology	Huttlin EL (2017)	1
CHEK2	2	PML	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang S (2002), Yang S (2002), Yang S (2002)	3
MAPK1	1	RPTOR	4	enzymatic study, pull down, enzymatic study	Carriere A (2011), Carriere A (2011), Langlais P (2011)	3
RYK	1	PTPRR	3	two hybrid	Yao Z (2017)	1
MAPK3	4	ITGB3	6	enzymatic study	Lin HY (2013)	1
RPS6KA1	3	RPS6KA2	2	affinity chromatography technology	Varjosalo M (2013)	1
BRAF	12	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology	Ren JG (2008), Ren JG (2008), Eisenhardt AE (2016)	3
CDC25C	0	MAPK1	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
PAK2	0	MYC	2	enzymatic study, affinity chromatography technology	Huang Z (2004), Benitah SA (2005)	2
TP53	0	TAF6	4	pull down, affinity chromatography technology, affinity chromatography technology	Wilhelm E (2010), Wilhelm E (2010), Wilhelm E (2010)	3
MKNK1	0	MAPK1	1	pull down, two hybrid, pull down	Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	3
RET	3	PTPRR	3	two hybrid	Yao Z (2017)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
PML	7	SP1	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Vallian S (1998), Vallian S (1998), Chuang YS (2011), Li J (2014), Li J (2014)	5
BRCA1	7	PFN1	0	affinity chromatography technology	Ertych N (2016)	1
CRP	0	MAPK1	1	two hybrid	Wang J (2011)	1
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
FBXW7	2	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Thompson BJ (2007), Welcker M (2004), Welcker M (2004), Yada M (2004), Yada M (2004), Yada M (2004), Koch HB (2007), Kim BY (2010), Cho HJ (2010), Popov N (2007), Fujii M (2006), Yumimoto K (2012), Diefenbacher ME (2015), Kourtis N (2015), Kourtis N (2015), Li J (2017), Wang Y (2017), Reiterer V (2017), Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	22
MAPK3	4	CELF1	0	affinity chromatography technology	Hein MY (2015)	1
PML	7	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015)	7
MAPK3	4	WDR43	0	affinity chromatography technology	Hein MY (2015)	1
MAP3K1	4	MBP	0	enzymatic study	Ninomiya-Tsuji J (2003)	1
IP6K3	1	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	ELK4	0	pull down, affinity chromatography technology	Chai Y (2001), Chai Y (2001)	2
HDAC4	10	TP53BP1	3	affinity chromatography technology, affinity chromatography technology	Kao GD (2003), Kao GD (2003)	2
BRAF	12	MAPK1	1	enzymatic study, genetic interference, enzymatic study	Ren JG (2008), Hart T (2015), Smith BD (2015)	3
TP53	0	ETV1	1	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
CREBBP	29	RPS6KA2	2	affinity chromatography technology	Nakajima T (1996)	1
CREBBP	29	SREBF2	5	far western blotting, affinity chromatography technology, affinity chromatography technology	Oliner JD (1996), Oliner JD (1996), Nath S (2014)	3
MAGEA11	1	PNKD	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ITGB3	6	ITGAV	7	x-ray crystallography, imaging technique, affinity chromatography technology	Xiong JP (2002), Moon HE (2015), Ward CM (2000)	3
MAPK3	4	HTRA2	1	enzymatic study	Plun-Favreau H (2007)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
APOL2	0	UBL4A	0	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	RPTOR	4	enzymatic study, pull down	Carriere A (2011), Carriere A (2011)	2
JUN	0	ETV1	1	pull down	Fuchs B (2003)	1
MAPK3	4	ATP5B	0	affinity chromatography technology	Galli S (2009)	1
RET	3	MAPK1	1	imaging technique	Chen TC (2014)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
MAPK3	4	HIST1H2AB	0	affinity chromatography technology, imaging technique	Galli S (2009), Galli S (2009)	2
MAPK3	4	FASN	15	affinity chromatography technology	Galli S (2009)	1
GAB2	3	USP21	2	affinity chromatography technology	Boldt K (2016)	1
SRC	2	RET	3	affinity chromatography technology	Melillo RM (1999)	1
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
RBM4	1	WDR43	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	SIRT6	2	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	RBM4	1	affinity chromatography technology	Hein MY (2015)	1
UBR5	13	MAPK3	4	affinity chromatography technology	Eblen ST (2003)	1
VCP	6	NUP58	0	affinity chromatography technology	Yu CC (2013)	1
IFI16	1	PML	7	affinity chromatography technology	Diner BA (2015)	1
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
MCM2	3	PRDX3	3	affinity chromatography technology	Drissi R (2015)	1
HNF4A	2	TP53	0	pull down, affinity chromatography technology	Maeda Y (2002), Huttlin EL (2017)	2
IQGAP1	1	RPTOR	4	affinity chromatography technology	Tekletsadik YK (2012)	1
MAPK3	4	ATP1A1	9	enzymatic study	Al-Khalili L (2004)	1
LYN	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Ren X (2003), Ren X (2003)	2
MAPK3	4	ARRB1	2	enzymatic study	Lin FT (1999)	1
RPS6KA3	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zhao Y (1996), Smith JA (1999), Wang J (2011), Varjosalo M (2013), Chrestensen CA (2002), Chen TC (2014), Kang S (2008)	7
RPS6KA2	2	JUN	0	enzymatic study	Zhao Y (1995)	1
BRCA1	7	HIST1H2AB	0	enzymatic study, enzymatic study	Kalb R (2014), McGinty RK (2014)	2
IFI16	1	NUP153	1	affinity chromatography technology	Diner BA (2015)	1
BRCA1	7	CSTF1	1	pull down	Kleiman FE (2001)	1
MAPK14	0	MKNK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	7
MAPK3	4	TH	2	enzymatic study	Haycock JW (1992)	1
ARRB1	2	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002)	2
MAPK3	4	NUDT21	0	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	ILKAP	2	biochemical	Wan C (2015)	1
SYNE2	19	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Warren DT (2010), Warren DT (2010), Warren DT (2010), Warren DT (2010)	4
CAV1	0	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
GPS2	0	TP53	0	affinity chromatography technology, pull down	Peng YC (2001), Peng YC (2001)	2
IFI16	1	UBTF	8	affinity chromatography technology	Diner BA (2015)	1
MAPK1	1	ID2	0	two hybrid	Wang J (2008)	1
MAPK3	4	AKR1C1	0	two hybrid	Wang J (2008)	1
DAPK1	6	TP53	0	affinity chromatography technology, affinity chromatography technology	Craig AL (2007), Craig AL (2007)	2
TP53	0	GTF2I	1	affinity chromatography technology	Horikawa I (2014)	1
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
MAP2K3	1	MAPK3	4	pull down	Zheng CF (1993)	1
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
PTPN7	3	DHPS	3	affinity chromatography technology	St-Denis N (2016)	1
SNCG	0	MAPK3	4	affinity chromatography technology	Pan ZZ (2002)	1
LGALS3	0	ATP1A1	9	affinity chromatography technology	Carvalho RS (2014)	1
RXRA	1	SP1	0	pull down, affinity chromatography technology	Suzuki Y (1999), Cheng YH (2008)	2
MAPK1	1	HIST1H4A	0	imaging technique	Galli S (2009)	1
FKBP2	0	BAG6	2	two hybrid	Stelzl U (2005)	1
VDR	2	BRCA1	7	affinity chromatography technology	Deng C (2009)	1
ATOH1	2	MAPK3	4	affinity chromatography technology	Cheng YF (2016)	1
MAPK3	4	RET	3	imaging technique	Chen TC (2014)	1
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
PML	7	ATF2	1	pull down	Vallian S (1998)	1
MAPK3	4	SCAND1	1	two hybrid	Vinayagam A (2011)	1
MAPK1	1	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	He C (2014), He C (2014)	2
MAPK1	1	IER3	0	enzymatic study, enzymatic study	Garcia J (2002), Letourneux C (2006)	2
PTPDC1	3	MAPK1	1	affinity chromatography technology	St-Denis N (2016)	1
KIRREL2	1	MAPK3	4	affinity chromatography technology	Huttlin EL (2015)	1
MAPK3	4	NUP58	0	two hybrid	Vinayagam A (2011)	1
MCM2	3	VCP	6	affinity chromatography technology	Drissi R (2015)	1
MAPK3	4	RAF1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Wang J (2009), Wang J (2009), Wang J (2009)	4
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
MAPK3	4	USP21	2	enzymatic study	Jin J (2016)	1
MAP2K1	8	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
ITGB3	6	PLA2G4A	1	affinity chromatography technology, affinity chromatography technology, pull down	Prevost N (2009), Prevost N (2009), Prevost N (2009)	3
NUP153	1	MAPK3	4	pull down	Casar B (2007)	1
RPS6KA1	3	MAPK3	4	affinity chromatography technology	Roux PP (2003)	1
CIITA	4	MAPK3	4	affinity chromatography technology	Voong LN (2008)	1
DUSP5	1	MAPK3	4	enzymatic study	Kwak SP (1995)	1
MAPK14	0	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Varjosalo M (2013), Huttlin EL (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Camps M (1998)	6
HTT	14	PPP2CA	7	unspecified method	Krauss S (2013)	1
NTMT1	0	MAPK1	1	biochemical	Havugimana PC (2012)	1
MAPK3	4	VPS52	0	two hybrid	Corominas R (2014)	1
VDAC1	2	PFN1	0	affinity chromatography technology	Malty RH (2017)	1
MAPK3	4	TTC9C	2	affinity chromatography technology	Hein MY (2015)	1
HDAC4	10	MAPK1	1	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
LAMTOR3	0	NUP58	0	biochemical	Havugimana PC (2012)	1
MCM2	3	HDAC6	0	affinity chromatography technology	Drissi R (2015)	1
MYC	2	C1QBP	0	affinity chromatography technology	Koch HB (2007)	1
MYC	2	RAF1	3	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Alexandrov I (1997), Koch HB (2007), Ivanov AA (2017)	3
CDC25C	0	MAPK3	4	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
PML	7	IER3	0	affinity chromatography technology	Kruse ML (2005)	1
MAPK3	4	MKNK1	0	enzymatic study	Fukunaga R (1997)	1
MAPK3	4	LGALS3	0	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	RALGDS	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002), Bhattacharya M (2002)	3
HDAC6	0	GEMIN5	1	affinity chromatography technology	Hein MY (2015)	1
LMNB2	2	MAPK3	4	biochemical	Wan C (2015)	1
SREBF2	5	ATF7IP	5	two hybrid	Bandyopadhyay S (2010)	1
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
IQGAP1	1	MAP2K1	8	affinity chromatography technology	Carmon KS (2014)	1
DUSP9	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, pull down	St-Denis N (2016), Li X (2016), Camps M (1998)	3
AVPR2	0	ARRB2	5	affinity chromatography technology	Tohgo A (2003)	1
PTPRE	1	ILKAP	2	affinity chromatography technology	Yadav L (2017)	1
DCP1A	1	PFKM	4	affinity chromatography technology	Li S (2014)	1
ARRB2	5	UBR5	13	affinity chromatography technology	Xiao K (2007)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
PTPN5	0	ATP5B	0	affinity chromatography technology	Yadav L (2017)	1
HDAC4	10	MAPK3	4	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
PLA2G4A	1	MAPK3	4	affinity chromatography technology	Letsiou E (2011)	1
MAPK3	4	AMOT	6	two hybrid	Corominas R (2014)	1
MAPK3	4	STAR	1	pull down, enzymatic study	Paz C (2009), Paz C (2009)	2
BAG6	2	UBR5	13	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
TP53BP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Matsuoka S (2007), Wang B (2002), Bohgaki T (2011), Ertych N (2016)	4
MAPK3	4	CUEDC2	0	enzymatic study	Zhang WN (2013)	1
RPS6KA6	0	RXRA	1	two hybrid	Vinayagam A (2011)	1
PTGDR	1	MAPK1	1	affinity chromatography technology	Binda C (2014)	1
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
MCM2	3	HIST1H2AB	0	affinity chromatography technology	Drissi R (2015)	1
VDR	2	RXRA	1	pull down, two hybrid, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique, imaging technique, pull down, pull down, pull down, pull down, pull down, two hybrid, pull down, two hybrid, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, imaging technique, two hybrid, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Song CS (2006), Dunlop TW (2005), Ting HJ (2005), Kim S (2005), Kim S (2005), Solomon C (2001), Liu YY (2000), Liu YY (2000), Rachez C (2000), Jimenez-Lara AM (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Ismail A (2004), Carvallo L (2008), Peleg S (2010), Albers M (2005), Herdick M (2000), Pedigo NG (2005), Hsieh JC (2003), Sorg BL (2006), Seuter S (2007), Seuter S (2007), Wang J (2011), Bartik L (2010), Rochel N (2011), Molnar F (2005), Ahmad K (2015), Ahmad K (2015)	32
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
VDAC1	2	BCL2L11	4	affinity chromatography technology	Sugiyama T (2002)	1
MAPK3	4	BRAF	12	genetic interference, imaging technique	Guan KL (2000), Chen TC (2014)	2
SP1	0	HTT	14	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down	Li SH (2002), Li SH (2002), Dunah AW (2002), Dunah AW (2002), Dunah AW (2002)	5
MAPK3	4	STAB2	15	affinity chromatography technology, affinity chromatography technology	Kyosseva SV (2008), Kyosseva SV (2008)	2
MAPK3	4	ATF7IP	5	affinity chromatography technology	Hein MY (2015)	1
SNRNP27	0	PAK2	0	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
NAB2	2	CUEDC2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	TIAL1	2	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	VDR	2	enzymatic study	Han S (2010)	1
DUSP8	0	MAPK3	4	affinity chromatography technology	Li X (2016)	1
VCP	6	SYMPK	3	affinity chromatography technology	Fogeron ML (2013)	1
BAG6	2	RET	3	affinity chromatography technology	Hein MY (2015)	1
MAP2K1	8	MAPK3	4	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Marti A (1997), Butch ER (1996), Schaeffer HJ (1998), Yung Y (2000), Yung Y (2000), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993), Wang J (2009)	9
PTPN7	3	MAPK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology	Pettiford SM (2000), Pettiford SM (2000), Saxena M (1999), Chen TC (2014), St-Denis N (2016)	5
BRCA1	7	FASN	15	affinity chromatography technology	Ertych N (2016)	1
LYN	2	GAB2	3	affinity chromatography technology	Xie ZH (2002)	1
MAPK3	4	LYN	2	affinity chromatography technology	Wei S (2000)	1
LMNB2	2	MAPK1	1	biochemical	Wan C (2015)	1
ARRB2	5	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Luan B (2009), Kim YM (2002), Lee J (2013)	4
VDR	2	HNF4A	2	affinity chromatography technology, affinity chromatography technology	Han S (2010), Han S (2010)	2
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
PAK2	0	SRC	2	pull down	Kaerkkaeinen S (2006)	1
NMD3	2	UBA1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
DUSP1	1	MAPK1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Slack DN (2001), Slack DN (2001), Calvisi DF (2008), Brondello JM (1999), Li X (2016)	5
SREBF2	5	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
MAP2K2	2	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
SNCA	0	MAPK3	4	affinity chromatography technology	Pan ZZ (2002)	1
IQGAP1	1	MAPK3	4	biochemical	Bourguignon LY (2005)	1
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
BRAF	12	PAK2	0	two hybrid	Bandyopadhyay S (2010)	1
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
MAPK3	4	JUN	0	enzymatic study	Pulverer BJ (1991)	1
ASNS	0	CSTF1	1	biochemical	Wan C (2015)	1
RPS6KA1	3	VCP	6	two hybrid	Vinayagam A (2011)	1
HDAC6	0	MAPK1	1	pull down, affinity chromatography technology	Williams KA (2013), Williams KA (2013)	2
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
NUP153	1	MAPK1	1	pull down	Casar B (2007)	1
MYC	2	NUP153	1	affinity chromatography technology	Koch HB (2007)	1
IFI16	1	SP1	0	affinity chromatography technology	Gariano GR (2012)	1
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
MAPK1	1	STAB2	15	affinity chromatography technology, affinity chromatography technology	Kyosseva SV (2008), Kyosseva SV (2008)	2
JUN	0	FBXW7	2	two hybrid, pull down, enzymatic study, unspecified method, affinity chromatography technology	Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Nateri AS (2004), Takada M (2017)	5
MAPK14	0	PAK2	0	affinity chromatography technology	Chan PM (2008)	1
VCP	6	FERMT2	0	affinity chromatography technology	Yu CC (2013)	1
ILKAP	2	PAK2	0	biochemical	Wan C (2015)	1
MAPK3	4	RPS6KA6	0	two hybrid	Vinayagam A (2011)	1
MAPK3	4	ITGAV	7	enzymatic study, affinity chromatography technology	Lin HY (2013), Lin HY (2013)	2
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
BRAF	12	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAPKAPK2	1	MAPK3	4	protein complementation assay, enzymatic study	Srivastav RK (2011), Coxon PY (2003)	2
SRC	2	SNCA	0	enzymatic study	Ellis CE (2001)	1
MAPK3	4	CHEK2	2	biochemical	Wan C (2015)	1
UBR5	13	C1QBP	0	affinity chromatography technology	Scialpi F (2015)	1
MAPK3	4	ID2	0	two hybrid	Wang J (2008)	1
MAPK1	1	HNF4A	2	enzymatic study	Han S (2010)	1
BRCA1	7	IQGAP1	1	affinity chromatography technology	Ertych N (2016)	1
TP53BP1	3	TRPS1	5	affinity chromatography technology	Woods NT (2012)	1
MAPK3	4	ILKAP	2	biochemical	Wan C (2015)	1
HDAC6	0	MAPK3	4	pull down, affinity chromatography technology, enzymatic study	Williams KA (2013), Williams KA (2013), Williams KA (2013)	3
BCL2L11	4	GTF2I	1	pull down	Hirano M (2004)	1
HDAC6	0	PML	7	affinity chromatography technology	Joshi P (2013)	1
MAPK3	4	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
MAP2K1	8	MAP2K2	2	biochemical, affinity chromatography technology	Stewart S (1999), Huttlin EL (2017)	2
PTPN5	0	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), St-Denis N (2016), Yadav L (2017)	3
MAPK3	4	SREBF1	5	enzymatic study	Kotzka J (2000)	1
DCUN1D1	0	ASNS	0	affinity chromatography technology	Bennett EJ (2010)	1
HTT	14	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang H (2010), Yu CC (2013), Fujita K (2013), Fujita K (2013)	4
DCUN1D1	0	TRIM54	1	two hybrid	Rolland T (2014)	1
TIAL1	2	VDAC1	2	biochemical	Havugimana PC (2012)	1
MAPK3	4	GAB2	3	enzymatic study, enzymatic study	Momose H (2003), Arnaud M (2004)	2
DCUN1D1	0	SCRIB	8	affinity chromatography technology	Bennett EJ (2010)	1
VDAC1	2	ATP5B	0	biochemical	Wan C (2015)	1
HTRA2	1	VCP	6	affinity chromatography technology	Raman M (2015)	1
PML	7	SYNE2	19	affinity chromatography technology, affinity chromatography technology, pull down	Warren DT (2010), Warren DT (2010), Warren DT (2010)	3
RNF114	0	USO1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK3	4	CDC23	3	two hybrid	Corominas R (2014)	1
GTF2I	1	MAPK3	4	affinity chromatography technology, enzymatic study	Kim DW (2000), Kim DW (2000)	2
VCP	6	LMNB2	2	affinity chromatography technology	Yu CC (2013)	1
ILKAP	2	MAPK14	0	enzymatic study	Zhang X (2017)	1
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
SRC	2	RXRA	1	pull down	Sun Y (2004)	1
ARRB1	2	MAP2K3	1	affinity chromatography technology, fluorescent resonance energy transfe	McLaughlin NJ (2006), McLaughlin NJ (2006)	2
MAPK1	1	LAMTOR3	0	pull down	Wunderlich W (2001)	1
PTGS2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Liou JY (2001), Liou JY (2001), Liou JY (2001), Chen SF (2010), Liou JY (2001), Liou JY (2001), Chen SF (2013), Chen SF (2013), Chen SF (2013)	9
FBXW7	2	SNCA	0	affinity chromatography technology	Baek HJ (2015)	1
BRCA1	7	GTF2I	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011), Tanikawa M (2011)	4
TTC27	3	NMD3	2	biochemical	Wan C (2015)	1
DUSP3	1	MAPK3	4	enzymatic study, affinity chromatography technology	Todd JL (1999), Todd JL (1999)	2
MAPK3	4	RBM26	3	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
LYN	2	TTYH3	1	affinity chromatography technology	Zhu J (2013)	1
MAPK3	4	SYMPK	3	affinity chromatography technology	Hein MY (2015)	1
SNCA	0	PRDX3	3	affinity chromatography technology	Hein MY (2015)	1
FBXW7	2	SREBF1	5	affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sundqvist A (2005), Sundqvist A (2005), Bengoechea-Alonso MT (2009), Welcker M (2013), Liu L (2016), Bengoechea-Alonso MT (2016), Bengoechea-Alonso MT (2016)	7
VDAC1	2	PRDX3	3	affinity chromatography technology	Malty RH (2017)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
MAPK3	4	MAPK3	4	pull down, affinity chromatography technology	Galli S (2009), Varjosalo M (2013)	2
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
MAPK1	1	GAB2	3	enzymatic study, enzymatic study	Momose H (2003), Arnaud M (2004)	2
PML	7	TBX3	0	affinity chromatography technology	Martin N (2012)	1
MAPK3	4	DCP1A	1	two hybrid	Corominas R (2014)	1
DUSP4	1	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology	Chen P (2001), Cadalbert LC (2010), Li X (2016)	3
MAPK1	1	RXRA	1	enzymatic study	Han S (2010)	1
MAPK3	4	RPS6KA4	0	affinity chromatography technology	Pierrat B (1998)	1
RBM4	1	TMEM189	0	biochemical	Havugimana PC (2012)	1
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
MAPK3	4	FKBP2	0	two hybrid	Wang J (2008)	1
SP1	0	TPM2	2	affinity chromatography technology	Chuang JY (2012)	1
RPS6KA4	0	MAPK1	1	affinity chromatography technology, pull down, pull down	Tomas-Zuber M (2001), Tomas-Zuber M (2001), Smith JA (2000)	3
C1QBP	0	NUP153	1	biochemical	Havugimana PC (2012)	1
MAP3K1	4	DCUN1D1	0	enzymatic study	Charlaftis N (2014)	1
SNCA	0	RALGDS	4	affinity chromatography technology	Kim KS (2010)	1
PTPDC1	3	DHPS	3	affinity chromatography technology	Li X (2016)	1
BRCA1	7	MCM2	3	affinity chromatography technology	Ertych N (2016)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
MAPK3	4	APOL2	0	affinity chromatography technology	Hein MY (2015)	1
MCM2	3	MAPK3	4	affinity chromatography technology	Drissi R (2015)	1
CSTF1	1	TTC27	3	biochemical	Wan C (2015)	1
MAPK3	4	CREM	1	enzymatic study	Yehia G (2001)	1
CAV1	0	VDAC1	2	affinity chromatography technology	Ramirez CM (2009)	1
PLA2G4A	1	MAPK1	1	affinity chromatography technology, enzymatic study	Letsiou E (2011), Boersch-Haubold AG (1998)	2
ITGAV	7	MAPK1	1	affinity chromatography technology	Lin HY (2013)	1
TP53	0	IQGAP1	1	affinity chromatography technology	Fogeron ML (2013)	1
BRCA1	7	DYNC1I2	0	affinity chromatography technology	Ertych N (2016)	1
GEMIN5	1	UBR5	13	affinity chromatography technology	Hein MY (2015)	1
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
SYNE2	19	MAPK3	4	pull down, affinity chromatography technology	Warren DT (2010), Warren DT (2010)	2
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
DCC	3	MAPK3	4	two hybrid	Forcet C (2002)	1
BAG6	2	SIRT6	2	affinity chromatography technology	Hein MY (2015)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
MAPK1	1	INSR	9	affinity chromatography technology	Lin YL (2000)	1
TP53	0	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Borellini F (1993), Jin W (2008), Dhar SK (2006), Lagger G (2003), Lagger G (2003), Lagger G (2003), Lagger G (2003), Sengupta S (2005), Sengupta S (2005), Lin RK (2010), Kim HA (2011), Sawaya BE (1998), St Clair S (2004), Innocente SA (2005), Innocente SA (2005), Ohlsson C (1998), Kong X (2013), Bocangel D (2009), Bocangel D (2009)	19
RYK	1	MAPK1	1	affinity chromatography technology	Berndt JD (2011)	1
MAPK3	4	UBTF	8	enzymatic study	Stefanovsky VY (2001)	1
MTMR12	1	DUSP1	1	affinity chromatography technology	Li X (2016)	1
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
MAPK1	1	TIAL1	2	enzymatic study	Reinhardt HC (2010)	1
DUSP6	2	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Muda M (1998), Xie XL (2015), Xie XL (2015), St-Denis N (2016), Li X (2016), Camps M (1998), Morita K (2015)	7
INSR	9	PTPRR	3	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
ADAM15	2	SRC	2	pull down, affinity chromatography technology	Kaerkkaeinen S (2006), Zhong JL (2008)	2
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
SPIB	3	JUN	0	pull down	Rao S (1999)	1
HNF4A	2	SNCG	0	affinity chromatography technology	Ewing RM (2007)	1
LGALS3	0	GTF2I	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Voss PG (2008), Voss PG (2008), Voss PG (2008)	3
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
DCP1A	1	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
DUSP1	1	DUSP3	1	affinity chromatography technology	Li X (2016)	1
TP53BP1	3	MAPK1	1	affinity chromatography technology	Woods NT (2012)	1
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
MAPK3	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ji S (2015), Ji S (2015), Ji S (2015)	3
ATF2	1	ATP1A1	9	affinity chromatography technology	Lau E (2012)	1
WDR83	1	LAMTOR3	0	affinity chromatography technology	Vomastek T (2004)	1
HNF4A	2	SREBF2	5	pull down	Inoue S (2011)	1
INSR	9	ARRB2	5	affinity chromatography technology	Luan B (2009)	1
MYC	2	TTC27	3	affinity chromatography technology	Koch HB (2007)	1
MAPK3	4	RNF114	0	two hybrid	Vinayagam A (2011)	1
DUSP1	1	MAPK3	4	two hybrid, enzymatic study, imaging technique	Slack DN (2001), Brondello JM (1999), Chen TC (2014)	3
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
MCM2	3	FASN	15	affinity chromatography technology	Drissi R (2015)	1
MAPK1	1	MAP2K1	8	affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sanz-Moreno V (2003), Sanz-Moreno V (2003), Robinson FL (2002), Yeung K (2000), Yeung K (2000), Wunderlich W (2001), Xu Be (2001), Xu Be (2001), Chen Z (2001), Srivastav RK (2011), Kubota Y (2011), Ho DT (2003), Wang J (2009), Jahrling JB (2014)	14
CAV1	0	MAPK3	4	affinity chromatography technology	Hua H (2003)	1
MAPK3	4	PCF11	2	affinity chromatography technology	Hein MY (2015)	1
PML	7	HTT	14	pull down, pull down	Guo L (2014), Guo L (2014)	2
MAPK3	4	GSE1	14	affinity chromatography technology	Hein MY (2015)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
NUDT21	0	PCF11	2	biochemical	Wan C (2015)	1
MAPK3	4	ETV1	1	enzymatic study	Janknecht R (2001)	1
MAPK3	4	ATF2	1	imaging technique	Chen TC (2014)	1
SNRNP27	0	DUSP3	1	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	TPM2	2	affinity chromatography technology	Hein MY (2015)	1
HDAC4	10	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Martin M (2008), Li J (2012)	2
GTF2I	1	TULP3	0	affinity chromatography technology	Boldt K (2016)	1
SPIB	3	MAPK3	4	biochemical, enzymatic study	Mao C (1996), Mao C (1996)	2
MAPK14	0	RPS6KA4	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	10
VCP	6	UBR5	13	affinity chromatography technology	Yu CC (2013)	1
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
RPS6KA2	2	MAPK3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), Chen TC (2014)	4
RAF1	3	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
HTRA2	1	MAPK14	0	two hybrid, affinity chromatography technology, enzymatic study	Faccio L (2000), Faccio L (2000), Plun-Favreau H (2007)	3
MAPK14	0	STAB2	15	affinity chromatography technology	Kyosseva SV (2008)	1
GPS2	0	HNF4A	2	affinity chromatography technology	Sanyal S (2007)	1
MAGEA11	1	PRDX3	3	two hybrid	Rual JF (2005)	1
PTPDC1	3	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Huttlin EL (2017), Li X (2016)	3
MAPK3	4	TTYH3	1	two hybrid	Wang J (2008)	1
GTF2I	1	MYC	2	pull down, affinity chromatography technology, affinity chromatography technology	Roy AL (1993), Roy AL (1993), Koch HB (2007)	3
MAPK1	1	ATF2	1	enzymatic study, enzymatic study, enzymatic study	Livingstone C (1995), Sanna MG (2002), Krump E (1997)	3
MAPK1	1	TH	2	enzymatic study	Haycock JW (1992)	1
UBL4A	0	ATP5B	0	affinity chromatography technology	Xu Y (2012)	1
MAPK1	1	UBTF	8	enzymatic study	Stefanovsky VY (2001)	1
CAV1	0	SRC	2	pull down	Li S (1996)	1
VDAC1	2	HIST1H2AB	0	affinity chromatography technology	Malty RH (2017)	1
MAPK14	0	ATF2	1	enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Raingeaud J (1995), Raingeaud J (1995), Chen Z (2001), Pillai VB (2011), Pillai VB (2011), Gianni M (2006), Deacon K (1997), Sudo T (2000), Mo JS (2010), Uddin S (2002), Stein B (1997), Yuan ZQ (2003), Coxon PY (2003), Li H (2001), Sun L (2007), Grimsey NJ (2015), Tang J (2008), Dixon DA (2006), Chen G (2000), Frantz B (1998), Tesker M (2016), Hwang SG (2014), Camps M (1998), Bakin AV (2002), Bulavin DV (1999)	25
TP53	0	TP53BP1	3	x-ray crystallography, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method	Derbyshire DJ (2002), Sengupta S (2004), Sengupta S (2004), Ekblad CM (2004), Lo KW (2005), Joo WS (2002), Derbyshire DJ (2002), Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Roy S (2010), Dai C (2011), Tembe V (2015), Cuella-Martin R (2016), Cuella-Martin R (2016), Tong Q (2015), Tong Q (2015)	17
DCUN1D1	0	FASN	15	affinity chromatography technology	Bennett EJ (2010)	1
MAPK3	4	VDAC1	2	affinity chromatography technology, imaging technique	Galli S (2009), Galli S (2009)	2
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
MAPK3	4	TEK	2	affinity chromatography technology	Varjosalo M (2013)	1
MAP2K1	8	BRAF	12	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, genetic interference, affinity chromatography technology	Loewenberg M (2006), Kilili GK (2010), Chen C (2008), Pardo OE (2006), Gloeckner CJ (2007), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Xie P (2009), Xie P (2009), Hart T (2015), Eisenhardt AE (2016)	12
MAPK1	1	VDAC1	2	imaging technique	Galli S (2009)	1
HDAC6	0	FASN	15	affinity chromatography technology	Watson GW (2016)	1
MAPK1	1	MAPKAPK2	1	affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology	Yannoni YM (2004), Srivastav RK (2011), Powell DW (2003), Krump E (1997)	4
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
ASNS	0	TTC27	3	biochemical	Wan C (2015)	1
AVPR2	0	VCP	6	affinity chromatography technology	Schwieger I (2008)	1
UBL4A	0	C1QBP	0	affinity chromatography technology	Xu Y (2012)	1
LAMTOR3	0	MAPK3	4	affinity chromatography technology	Schaeffer HJ (1998)	1
TP53BP1	3	FASN	15	affinity chromatography technology	Woods NT (2012)	1
MAPK1	1	C1QBP	0	enzymatic study	Majumdar M (2002)	1
ARRB1	2	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009), Buchanan FG (2006), Buchanan FG (2006), Lee J (2013)	5
VCP	6	MAPK1	1	affinity chromatography technology	Yu CC (2013)	1
TP53	0	PTGS2	0	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	King JG (2001), Choi EM (2009), Choi EM (2009), Choi EM (2009), Tang HY (2006), Tang HY (2006), Lin C (2011), Lin C (2011), Choi EM (2005), Choi EM (2005), Choi EM (2005), Choi EM (2005)	12
HTT	14	CREBBP	29	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Nucifora FC (2001), Cong SY (2005), Cong SY (2005), Steffan JS (2001)	4
BRCA1	7	CDC25C	0	enzymatic study	Shabbeer S (2013)	1
VCP	6	WDR43	0	affinity chromatography technology	Yu CC (2013)	1
SNRNP27	0	USO1	1	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	ELK1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, enzymatic study	Han S (2010), Zhu Z (2005), Tapinos N (2005), Coxon PY (2003), Chen TC (2014), Dixon DA (2006)	6
ARRB2	5	SYNE2	19	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	HNF4A	2	enzymatic study	Han S (2010)	1
MAPK3	4	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
MAP2K3	1	MAPK14	0	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Chen Z (2001), Casar B (2007), Deacon K (1997), Mo JS (2010), Varjosalo M (2013), Huttlin EL (2015), Li L (2014), Huttlin EL (2017), Ivanov AA (2017)	9
CHEK2	2	CDC25C	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Eymin B (2006), Xu X (2002), Yang S (2002), Zannini L (2003), Buscemi G (2001), Zhou BB (2000), Magni M (2014), Wu X (2001), Fujimoto H (2006)	9
MAGED1	0	BAG6	2	affinity chromatography technology	Ewing RM (2007)	1
VCP	6	TP53BP1	3	affinity chromatography technology	Yu CC (2013)	1
MAPK3	4	MAGEA11	1	enzymatic study	Askew EB (2009)	1
ATF2	1	VDAC1	2	affinity chromatography technology	Lau E (2012)	1
CHEK2	2	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Lee JS (2000), Lee JS (2000), Chabalier-Taste C (2008), Chabalier-Taste C (2008), Liu Y (2002), Inoue Y (2007), Dutta D (2015), Dutta D (2015)	8
MAPK3	4	RALGDS	4	imaging technique	Chen TC (2014)	1
SRC	2	ITGB3	6	enzymatic study	Kirk RI (2000)	1
IQGAP1	1	MAP2K2	2	affinity chromatography technology	Carmon KS (2014)	1
DUSP3	1	MAPK1	1	enzymatic study, affinity chromatography technology	Todd JL (1999), Todd JL (1999)	2
MAPK3	4	METTL2B	0	biochemical	Wan C (2015)	1
SIRT6	2	GTF2I	1	affinity chromatography technology	Simeoni F (2013)	1
VCP	6	CHEK2	2	affinity chromatography technology	Matsuoka S (2007)	1
SIRT6	2	UBR5	13	affinity chromatography technology	Simeoni F (2013)	1
SREBF1	5	HNF4A	2	pull down, affinity chromatography technology	Ponugoti B (2007), Ponugoti B (2010)	2
IFI16	1	WDR43	0	affinity chromatography technology	Diner BA (2015)	1
MCM2	3	C1QBP	0	affinity chromatography technology	Drissi R (2015)	1
FBXW7	2	ITGAV	7	genetic interference	Bailey ML (2015)	1
PEA15	0	MAPK1	1	two hybrid, pull down, affinity chromatography technology	Formstecher E (2001), Formstecher E (2001), Casar B (2007)	3
CREBBP	29	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Pao GM (2000), Pao GM (2000), Benezra M (2003), Fan S (2002), Fan S (2002), Neish AS (1998), Nakuci E (2006), Crowe DL (2006), Chai YL (1999)	9
LTN1	8	ILKAP	2	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Merienne K (2001), Merienne K (2001)	2
DHPS	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
MAPK3	4	TRPS1	5	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
SP1	0	ATF7IP	5	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down	Liu L (2009), Liu L (2009), Chang LK (2005), Chang LK (2005), Ichimura T (2005), Ichimura T (2005)	6
UBL4A	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012)	2
CHEK2	2	TP53BP1	3	affinity chromatography technology	Matsuoka S (2007)	1
PTPN7	3	MAPK14	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
HDAC6	0	ATP5B	0	affinity chromatography technology	Watson GW (2016)	1
DUSP9	0	DUSP6	2	affinity chromatography technology	Li X (2016)	1
PTPN5	0	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), St-Denis N (2016), Yadav L (2017)	3
MAPK1	1	UBR5	13	enzymatic study, affinity chromatography technology	Eblen ST (2003), Eblen ST (2003)	2
VDAC1	2	LMNB2	2	affinity chromatography technology	Malty RH (2017)	1
MAPK3	4	SCRIB	8	enzymatic study, pull down, affinity chromatography technology	Nagasaka K (2010), Nagasaka K (2010), Nagasaka K (2010)	3
SNCA	0	ARRB1	2	affinity chromatography technology	Kim KS (2010)	1
MCM2	3	PFN1	0	affinity chromatography technology	Drissi R (2015)	1
MAPK3	4	DYNC1I2	0	affinity chromatography technology	Hein MY (2015)	1
VCP	6	MAPK3	4	affinity chromatography technology	Yu CC (2013)	1
UXS1	2	TTYH3	1	affinity chromatography technology	Huttlin EL (2017)	1
PML	7	RXRA	1	pull down, imaging technique	Zhong S (1999), Bellodi C (2006)	2
IFI16	1	SNRNP27	0	affinity chromatography technology	Diner BA (2015)	1
VDR	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Stambolsky P (2010), Stambolsky P (2010)	2
PTPDC1	3	MAPK3	4	affinity chromatography technology	St-Denis N (2016)	1
CREBBP	29	HNF4A	2	two hybrid, affinity chromatography technology, pull down, genetic interference, pull down, pull down, enzymatic study, pull down, affinity chromatography technology	Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Yoshida E (1997), Dell H (1999), Surapureddi S (2008), Soutoglou E (2000), Soutoglou E (2000), Green VJ (1998)	9
VCP	6	MAP2K1	8	affinity chromatography technology	Yu CC (2013)	1
MAPK3	4	UBL4A	0	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	HTT	14	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	CIITA	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Voong LN (2008), Voong LN (2008), Voong LN (2008)	3
AVPR2	0	MAPK3	4	affinity chromatography technology	Tohgo A (2003)	1
MAPK14	0	SP1	0	affinity chromatography technology	Pan W (2008)	1
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
RYK	1	TP53	0	affinity chromatography technology	Berndt JD (2011)	1
RAF1	3	VDAC1	2	affinity chromatography technology	Le Mellay V (2002)	1
ARRB2	5	C1QBP	0	affinity chromatography technology	Xiao K (2007)	1
DCUN1D1	0	MAPK3	4	biochemical	Wan C (2015)	1
SNCA	0	MAPK1	1	affinity chromatography technology, pull down	Pan ZZ (2002), Iwata A (2001)	2
BRCA1	7	NUP153	1	unspecified method, affinity chromatography technology	Rodriguez M (2003), Ertych N (2016)	2
ATOH1	2	UBR5	13	affinity chromatography technology	Cheng YF (2016)	1
MAPK3	4	CPXM1	1	two hybrid	Wang J (2008)	1
MAPKAPK2	1	ETV1	1	enzymatic study	Janknecht R (2001)	1
MAPK14	0	RPS6KA3	2	affinity chromatography technology	Tanoue T (2001)	1
MAPK14	0	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
IQGAP1	1	MAPK1	1	biochemical, affinity chromatography technology	Bourguignon LY (2005), Bourguignon LY (2005)	2
TRIM54	1	USP21	2	enzymatic study	Loch CM (2012)	1
MAPK1	1	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
DAPK1	6	MAPK1	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen CH (2005)	4
MYC	2	PML	7	affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2005), Buschbeck M (2007), Buschbeck M (2007)	3
SNRNP27	0	ILKAP	2	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	USO1	1	affinity chromatography technology	Ertych N (2016)	1
MAPK1	1	CHEK2	2	biochemical	Wan C (2015)	1
DUSP6	2	DUSP8	0	affinity chromatography technology	Li X (2016)	1
MAPK3	4	ZC3HC1	1	enzymatic study	Illert AL (2012)	1
MAPK1	1	VDR	2	enzymatic study	Han S (2010)	1
CAV1	0	PPP2CA	7	pull down, affinity chromatography technology	Li L (2003), Zhang X (2007)	2
MAPK1	1	ELK4	0	enzymatic study	Janknecht R (1997)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
PEA15	0	MAPK3	4	two hybrid, two hybrid	Formstecher E (2001), Vinayagam A (2011)	2
DUSP9	0	LTN1	8	affinity chromatography technology	St-Denis N (2016)	1
TEK	2	PTPRR	3	two hybrid	Yao Z (2017)	1
MAPK3	4	USO1	1	affinity chromatography technology	How PC (2011)	1
MAPK14	0	DUSP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), Slack DN (2001), Slack DN (2001), Bandyopadhyay S (2010), Chen TC (2014), St-Denis N (2016), Li X (2016)	7
USP21	2	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
BRCA1	7	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
MAPK3	4	RXRA	1	enzymatic study	Han S (2010)	1
MAP2K2	2	MAPK1	1	two hybrid, protein complementation assay, pull down, enzymatic study	Robinson FL (2002), Srivastav RK (2011), Ho DT (2003), Ho DT (2003)	4
MAP2K2	2	RAF1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Xia Y (1998), Wang J (2011), Wang J (2009), Johnson SE (2006)	4
BRCA1	7	LGALS3	0	affinity chromatography technology	Carvalho RS (2014)	1
FERMT2	0	MAPK3	4	biochemical	Wan C (2015)	1
CSTF2T	4	CSTF1	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
BRCA1	7	PFKM	4	affinity chromatography technology	Ertych N (2016)	1
VDR	2	JUN	0	pull down	Towers TL (1999)	1
TP53BP1	3	MAPK3	4	affinity chromatography technology	Woods NT (2012)	1
MYC	2	VDR	2	affinity chromatography technology	Salehi-Tabar R (2012)	1
MYC	2	MAP2K3	1	genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Toyoshima M (2012), Ivanov AA (2017), Ivanov AA (2017), Ivanov AA (2017)	4
SP1	0	MYOG	1	pull down, pull down	Biesiada E (1999), Biesiada E (1999)	2
ARRB1	2	ATP5B	0	affinity chromatography technology	Xiao K (2007)	1
MAPK3	4	TAF6	4	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	GEMIN5	1	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	MTMR12	1	biochemical	Wan C (2015)	1
VCP	6	NMD3	2	affinity chromatography technology	Yu CC (2013)	1
USP21	2	TP53	0	enzymatic study	Fernandez-Majada V (2016)	1
ASNS	0	NMD3	2	biochemical	Wan C (2015)	1
MAPK3	4	NMD3	2	biochemical	Wan C (2015)	1
VDR	2	SRC	2	imaging technique, two hybrid, two hybrid, affinity chromatography technology, pull down	Saramaeki A (2006), Bettoun DJ (2003), Ellison TI (2005), Han S (2010), Choi M (2011)	5
IQGAP1	1	TPM2	2	affinity chromatography technology	Hein MY (2015)	1
MAP2K2	2	MAPK3	4	two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down	Marti A (1997), Butch ER (1996), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993)	5
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
SREBF1	5	ID2	0	pull down	Moldes M (1999)	1
UBA1	1	MAPK3	4	biochemical	Wan C (2015)	1
MAPK3	4	LTN1	8	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
MYC	2	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Arnold HK (2009), Junttila MR (2007), Cianfanelli V (2015), Cianfanelli V (2015)	4
CHEK2	2	UBR5	13	affinity chromatography technology, affinity chromatography technology	Henderson MJ (2006), Henderson MJ (2006)	2
MAGEA11	1	BCL2L11	4	two hybrid	Rolland T (2014)	1
UBL4A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wang Q (2011), Wang Q (2011), Mariappan M (2010), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Mock JY (2015), Mock JY (2015), Kuwabara N (2015), Kuwabara N (2015), Kuwabara N (2015), Wu W (2014), Wu W (2014), Wan C (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017)	19
FERMT2	0	PFKM	4	biochemical	Wan C (2015)	1
DCUN1D1	0	MAPK1	1	biochemical	Wan C (2015)	1
CREBBP	29	SREBF1	5	far western blotting, affinity chromatography technology, biochemical, pull down, pull down, imaging technique, pull down, pull down, pull down	Oliner JD (1996), Oliner JD (1996), Naeaer AM (1999), Naeaer AM (1999), Naeaer AM (1998), Yang F (2006), Yang F (2006), Yang F (2006), Ericsson J (1998)	9
UBR5	13	WDR43	0	biochemical	Havugimana PC (2012)	1
FERMT2	0	MAPK1	1	biochemical	Wan C (2015)	1
SP1	0	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kardassis D (1999), Hung JJ (2006), Chen BK (2007), Chen BK (2007), Chen BK (2007)	5
BRAF	12	MAP2K2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	3
MAPK3	4	TMEM189	0	affinity chromatography technology	Hein MY (2015)	1
BRAF	12	FBXW7	2	affinity chromatography technology	Hernandez MA (2016)	1
GAB2	3	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
MAPK3	4	CRP	0	two hybrid	Wang J (2008)	1
MKNK1	0	CREBBP	29	two hybrid	Bandyopadhyay S (2010)	1
ATF2	1	PFN1	0	affinity chromatography technology	Lau E (2012)	1
MAPK3	4	HIST1H4A	0	affinity chromatography technology, imaging technique	Galli S (2009), Galli S (2009)	2
ARRB2	5	MAP2K1	8	affinity chromatography technology	Luttrell LM (2001)	1
HNF4A	2	TAF6	4	pull down	Green VJ (1998)	1
PTPN7	3	MAPK3	4	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Pettiford SM (2000), Saxena M (1999), Saxena M (1999), St-Denis N (2016)	4
FASN	15	ASNS	0	biochemical	Wan C (2015)	1
PTGDR	1	MAPK3	4	affinity chromatography technology	Binda C (2014)	1
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
MAPK3	4	DUSP9	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
BRCA1	7	TIAL1	2	affinity chromatography technology	Ertych N (2016)	1
RPS6KA1	3	ILKAP	2	biochemical	Wan C (2015)	1
MAPK1	1	HIST1H2AB	0	imaging technique	Galli S (2009)	1
GPS2	0	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK3	4	IER3	0	affinity chromatography technology	Garcia J (2002)	1
DCUN1D1	0	C1QBP	0	affinity chromatography technology	Bennett EJ (2010)	1
SRC	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Whiting RJ (2012), Ruas JL (2005), Ruas JL (2005)	3
MAPK3	4	CSTF2T	4	affinity chromatography technology	Hein MY (2015)	1
MAPK3	4	C1QBP	0	enzymatic study	Majumdar M (2002)	1
BRCA1	7	IFI16	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Aglipay JA (2003), Dutta D (2015), Dutta D (2015), Dutta D (2015)	4
PEA15	0	RPS6KA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Vaidyanathan H (2003), Vaidyanathan H (2003), Vaidyanathan H (2003)	3
PTPRR	3	DHPS	3	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
RXRA	1	HDAC4	10	pull down	Franco PJ (2003)	1
MAPK14	0	GMFB	0	affinity chromatography technology	Lim R (1996)	1
MAPK1	1	ZC3HC1	1	enzymatic study	Illert AL (2012)	1
TULP3	0	PML	7	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	RPTOR	4	affinity chromatography technology	Ertych N (2016)	1
TTC27	3	MAPK3	4	biochemical	Wan C (2015)	1
MAPK14	0	CDC25C	0	enzymatic study, pull down	Bulavin DV (2001), Bulavin DV (2001)	2
IFI16	1	NUP58	0	affinity chromatography technology	Diner BA (2015)	1
MAPK14	0	ETV1	1	enzymatic study	Janknecht R (2001)	1
MAPK3	4	PPP2CA	7	affinity chromatography technology	Quevedo C (2003)	1
MAPK3	4	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
BAG6	2	WDR83	1	affinity chromatography technology	Hein MY (2015)	1
RPS6KA3	2	MAPK3	4	affinity chromatography technology, imaging technique	Zhao Y (1996), Chen TC (2014)	2
CAV1	0	SNCA	0	pull down	Madeira A (2011)	1
GTF2I	1	MAPK1	1	affinity chromatography technology	Kim DW (2001)	1
JUN	0	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
CPLX4	0	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	RAF1	3	affinity chromatography technology, pull down	Cleghon V (1994), Cleghon V (1994)	2
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
HTT	14	NUP58	0	two hybrid	Suter B (2013)	1
CDC25C	0	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
DCUN1D1	0	PRDX3	3	affinity chromatography technology	Bennett EJ (2010)	1
MAPK3	4	IRS1	7	enzymatic study	Luo M (2007)	1
DCUN1D1	0	TIAL1	2	affinity chromatography technology	Bennett EJ (2010)	1
RYK	1	MAPK3	4	affinity chromatography technology	Berndt JD (2011)	1
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
MYC	2	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
VCP	6	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Ohama T (2010), Yakovlev VA (2013)	2
DUSP8	0	MAPK1	1	affinity chromatography technology	Li X (2016)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
MAPK3	4	PFKM	4	two hybrid	Wang J (2008)	1
CREBBP	29	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Fang X (2005), Wang Z (2003)	2
MAPK1	1	SREBF1	5	enzymatic study	Kotzka J (2000)	1
MAPK3	4	ELK4	0	enzymatic study	Janknecht R (1997)	1
MCM2	3	ATP5B	0	affinity chromatography technology	Drissi R (2015)	1
CSTF1	1	DCUN1D1	0	biochemical	Wan C (2015)	1
NTMT1	0	MAPK3	4	biochemical	Havugimana PC (2012)	1
ILKAP	2	RPS6KA3	2	enzymatic study	Zhang X (2017)	1
INSR	9	CAV1	0	affinity chromatography technology	Nystrom FH (1999)	1
ADAM15	2	MAPK1	1	affinity chromatography technology	Zhong JL (2008)	1
VCP	6	DYNC1I2	0	affinity chromatography technology	Yu CC (2013)	1
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
IP6K3	1	UBL4A	0	affinity chromatography technology	Hein MY (2015)	1
BRAF	12	RPTOR	4	affinity chromatography technology	Huttlin EL (2017)	1
ASNS	0	MAPK3	4	biochemical	Wan C (2015)	1
MCM2	3	IQGAP1	1	affinity chromatography technology	Drissi R (2015)	1
MAPK3	4	IP6K3	1	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	HIST1H4A	0	enzymatic study, enzymatic study, enzymatic study	Perissi V (1999), Pasheva E (2004), Yasuda J (2004)	3
ADAM15	2	MAPK3	4	affinity chromatography technology	Zhong JL (2008)	1
MAP2K1	8	LAMTOR3	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Wunderlich W (2001), Schaeffer HJ (1998), Schaeffer HJ (1998)	3
BRCA1	7	UBTF	8	affinity chromatography technology	Johnston R (2016)	1
UBL4A	0	GEMIN5	1	affinity chromatography technology	Xu Y (2012)	1
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
IFI16	1	MAPK3	4	affinity chromatography technology	Diner BA (2015)	1
MAPK3	4	PRDX3	3	affinity chromatography technology	Galli S (2009)	1
CHEK2	2	PPP2CA	7	affinity chromatography technology, enzymatic study	Dozier C (2004), Liang X (2006)	2
MAPK3	4	INSR	9	affinity chromatography technology	Lin YL (2000)	1
CIITA	4	PML	7	imaging technique	Forlani G (2017)	1
SREBF1	5	SP1	0	pull down, biochemical	Bennett MK (1999), Naeaer AM (1999)	2
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
MAPK3	4	PFKFB1	1	two hybrid	Wang J (2008)	1
MAPK3	4	FOXP2	13	two hybrid	Corominas R (2014)	1
CSTF1	1	MAPK3	4	biochemical	Wan C (2015)	1
RPS6KA1	3	RPS6KA3	2	affinity chromatography technology	Varjosalo M (2013)	1
DAPK1	6	MAPK3	4	two hybrid, pull down, affinity chromatography technology, imaging technique	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen TC (2014)	4
MAPK3	4	PHF3	8	affinity chromatography technology	Varjosalo M (2013)	1
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
DUSP4	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
SNCA	0	VDAC1	2	affinity chromatography technology	McFarland MA (2008)	1
MCM2	3	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Saade E (2009), Drissi R (2015), Huttlin EL (2017)	5
RPS6KA1	3	RPTOR	4	enzymatic study	Carriere A (2008)	1
MAPK14	0	DUSP6	2	affinity chromatography technology	Tanoue T (2001)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
KHDRBS2	1	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
MAGEA11	1	VTA1	1	two hybrid	Rual JF (2005)	1
MYC	2	MAPK3	4	pull down	Jin Z (2004)	1
SNCA	0	ELK1	2	affinity chromatography technology, affinity chromatography technology	Iwata A (2001), Iwata A (2001)	2
LYN	2	KHDRBS2	1	affinity chromatography technology, affinity chromatography technology	Zhu J (2013), Zhu J (2013)	2
MAPK3	4	GALE	0	biochemical	Wan C (2015)	1
CREBBP	29	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	de Nigris F (2007), de Nigris F (2007), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003)	7
SNRNP27	0	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
DUSP4	1	MAPK14	0	pull down, affinity chromatography technology	Chen P (2001), Li X (2016)	2
DCP1A	1	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	CREM	1	pull down	Laurance ME (1997)	1
MAPK3	4	ZNF219	3	two hybrid	Vinayagam A (2011)	1
ARRB1	2	FASN	15	affinity chromatography technology	Xiao K (2007)	1
MAP2K1	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karandikar M (2000), Karandikar M (2000), Tu Z (2003)	3
ZDHHC11	2	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
MAPK3	4	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	He C (2014), He C (2014)	2
RAF1	3	PPP2CA	7	affinity chromatography technology	Rajalingam K (2005)	1
DCC	3	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Tcherkezian J (2010), Tcherkezian J (2010)	2
MAPK3	4	HADH	1	affinity chromatography technology	Galli S (2009)	1
UXS1	2	MAPK3	4	affinity chromatography technology	Huttlin EL (2017)	1
PTPN5	0	MAPK14	0	affinity chromatography technology	Li X (2016)	1
MAGEA11	1	STAR	1	two hybrid	Rolland T (2014)	1
TP53BP1	3	HIST1H4A	0	unspecified method, x-ray crystallography, pull down	Botuyan MV (2006), Botuyan MV (2006), Jacquet K (2016)	3
RAF1	3	MAP2K3	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ILKAP	2	CHEK2	2	biochemical	Wan C (2015)	1
ADAM15	2	LYN	2	pull down	Kaerkkaeinen S (2006)	1
MAPK3	4	TBX3	0	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	PTPRE	1	affinity chromatography technology	Toledano-Katchalski H (2003)	1
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
MAGED1	0	UBR5	13	affinity chromatography technology	Ewing RM (2007)	1
RPS6KA6	0	MBP	0	biochemical	Havugimana PC (2012)	1
MAPK1	1	CUEDC2	0	enzymatic study	Zhang WN (2013)	1
TEK	2	ILKAP	2	two hybrid	Yao Z (2017)	1
MAPK3	4	MAGED1	0	two hybrid	Corominas R (2014)	1
MAPK3	4	NAB2	2	two hybrid	Corominas R (2014)	1