PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K7	5	JUN	0	enzymatic study	Sundarrajan M (2003)	1
EP300	36	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li XN (2009), Li XN (2009), Mahmud DL (2002), Li X (2015)	4
RPS6KA1	3	GSK3B	1	enzymatic study	Larrea MD (2009)	1
VAV1	2	JUN	0	enzymatic study	Kaminuma O (2001)	1
ICK	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Fu Z (2006), August A (1996)	2
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
DUSP6	2	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muda M (1998), Muda M (1998), Xie XL (2015), Xie XL (2015), St-Denis N (2016), Li X (2016)	6
MAPK14	0	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sudo T (2000), Plun-Favreau H (2007), Ge B (2003), Chen G (2000)	4
KRAS	1	RAF1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, fluorescent resonance energy transfe	Li W (2000), Kiyono M (2000), Sui X (2009), Lito P (2012), Rajalingam K (2005), Zhu J (2005), Blaukat A (2000), So J (2015), Ji H (2016), Hart T (2015), Wang T (2017), Saito T (2004), Ivanov AA (2017)	13
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
NCOA3	3	PGR	1	pull down, affinity chromatography technology, affinity chromatography technology	Giangrande PH (2000), An BS (2009), An BS (2006)	3
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
CSNK2A1	15	SNCA	0	enzymatic study, enzymatic study	Payton JE (2004), Okochi M (2000)	2
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
MAPK1	1	ELK1	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Eblen ST (2003), Cano E (1995), Cano E (1995), Himpel S (2000), Han S (2010), Zhang X (2011), Basaki Y (2002), Iwata A (2001), Corbit KC (2003), Zhu Z (2005), Bourguignon LY (2005), Ahmed N (2002), Janknecht R (1997), Cavigelli M (1995), Tapinos N (2005), Eliopoulos AG (2006), Ho DT (2003), Kendrick TS (2004)	18
PPARG	0	MAP2K1	8	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Burgermeister E (2011), Burgermeister E (2011), Burgermeister E (2007), Burgermeister E (2007), Burgermeister E (2007)	5
TSC2	17	RPS6KA1	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Roux PP (2004), Rolfe M (2005), Roux PP (2004), Roux PP (2004)	4
ADAM17	2	MAPK1	1	pull down, enzymatic study, affinity chromatography technology	Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002), Diaz-Rodriguez E (2002)	3
ATF2	1	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Rong Y (2010), Rong Y (2010)	2
RAF1	3	BCL2	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang HG (1996), Wang HG (1996), Wang HG (1996), Jin S (2005), Jin S (2005), Mazzocca A (2003)	6
HSF4	0	HSF1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
MAP3K1	4	NOTCH1	25	enzymatic study, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
HDAC4	10	CIITA	4	affinity chromatography technology, affinity chromatography technology	Wang AH (2005), Wang AH (2005)	2
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
NOTCH1	25	VAV1	2	affinity chromatography technology	Yatim A (2012)	1
UBR5	13	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ling S (2011), Ling S (2011), Ling S (2011), Fogeron ML (2013), Flack JE (2017)	5
SMAD1	0	FOXO3	1	affinity chromatography technology	Sapkota G (2007)	1
PPARG	0	SMAD3	1	affinity chromatography technology	Lin LC (2011)	1
RPS6KA2	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), So J (2015)	4
MAPK1	1	RPTOR	4	enzymatic study, pull down, enzymatic study	Carriere A (2011), Carriere A (2011), Langlais P (2011)	3
MAPK1	1	HSF1	1	affinity chromatography technology, pull down	Dai R (2000), Dai R (2000)	2
BCL2	0	MYC	2	affinity chromatography technology, imaging technique	Jin Z (2004), Jin Z (2004)	2
RPS6KA1	3	RPS6KA2	2	affinity chromatography technology	Varjosalo M (2013)	1
BRAF	12	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology	Ren JG (2008), Ren JG (2008), Eisenhardt AE (2016)	3
CDC25C	0	MAPK1	1	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
UBR5	13	TOB1	1	affinity chromatography technology	Su H (2011)	1
MKNK1	0	MAPK1	1	pull down, two hybrid, pull down	Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	3
TOP2A	2	GSK3B	1	affinity chromatography technology	Chen MC (2011)	1
PML	7	SP1	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Vallian S (1998), Vallian S (1998), Chuang YS (2011), Li J (2014), Li J (2014)	5
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
GSK3B	1	JUN	0	enzymatic study, imaging technique	Chen BK (2007), Chen TC (2014)	2
MAP3K1	4	MBP	0	enzymatic study	Ninomiya-Tsuji J (2003)	1
VAV1	2	RAF1	3	affinity chromatography technology	Song JS (1996)	1
ADAM17	2	TNFRSF1A	3	enzymatic study	Tellier E (2006)	1
JUN	0	CSNK2A1	15	pull down, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Uhle S (2003)	3
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
BRAF	12	MAPK1	1	enzymatic study, genetic interference, enzymatic study	Ren JG (2008), Hart T (2015), Smith BD (2015)	3
MKNK2	1	MAPK1	1	affinity chromatography technology, pull down, two hybrid, pull down	Scheper GC (2003), Waskiewicz AJ (1997), Waskiewicz AJ (1997), Smith JA (2000)	4
MAPK14	0	MKNK2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Bandyopadhyay S (2010), Varjosalo M (2013), Huttlin EL (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	6
PTPRR	3	MAPK3	4	pull down, pull down, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), St-Denis N (2016)	3
MAPK3	4	RPTOR	4	enzymatic study, pull down	Carriere A (2011), Carriere A (2011)	2
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
ESR1	0	KARS	1	pull down	Nalvarte I (2010)	1
STAT5A	4	ESR1	0	pull down, affinity chromatography technology	Faulds MH (2001), Wang Y (2004)	2
FHL2	0	EP300	36	pull down, affinity chromatography technology	Labalette C (2004), Labalette C (2004)	2
MAPK3	4	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Wasserman T (2010), Tresini M (2001)	4
STYX	1	PEBP1	0	affinity chromatography technology	Reiterer V (2017)	1
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
SMAD3	1	NCOA3	3	affinity chromatography technology	Xi Q (2008)	1
UBR5	13	MAPK3	4	affinity chromatography technology	Eblen ST (2003)	1
MAPK1	1	KRAS	1	affinity chromatography technology, genetic interference	Blaukat A (2000), Hart T (2015)	2
JUN	0	MAPK1	1	affinity chromatography technology, enzymatic study, pull down	Kumar NV (2001), Zuniga A (1999), Zuniga A (1999)	3
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
IQGAP1	1	RPTOR	4	affinity chromatography technology	Tekletsadik YK (2012)	1
RPS6KA3	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zhao Y (1996), Smith JA (1999), Wang J (2011), Varjosalo M (2013), Chrestensen CA (2002), Chen TC (2014), Kang S (2008)	7
SMAD3	1	HDAC4	10	affinity chromatography technology, pull down	Kang JS (2005), Kang JS (2005)	2
RPS6KA2	2	JUN	0	enzymatic study	Zhao Y (1995)	1
MAPK14	0	MKNK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanoue T (2001), Bandyopadhyay S (2010), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	7
FHL2	0	SFPQ	2	two hybrid	Dye BT (2001)	1
SYNE2	19	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Warren DT (2010), Warren DT (2010), Warren DT (2010), Warren DT (2010)	4
PPARG	0	STAT5A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trombetta A (2013), Trombetta A (2013), Dentelli P (2009), Dentelli P (2009)	4
DAPK1	6	TP53	0	affinity chromatography technology, affinity chromatography technology	Craig AL (2007), Craig AL (2007)	2
MAPK1	1	TSC2	17	pull down, affinity chromatography technology	Ma L (2005), Ma L (2005)	2
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
ESR1	0	MAPKAPK2	1	affinity chromatography technology	Tarallo R (2011)	1
PPARG	0	SP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Costa V (2008), Singh AK (2010), Singh AK (2010), Zhang XH (2012), Zhang XH (2012), Zurlo D (2014), Zurlo D (2014)	7
BRCA1	7	NCOA3	3	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down	Rodriguez M (2003), Nakuci E (2006), Nakuci E (2006), Nakuci E (2006)	4
FHL2	0	ITGB6	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
MAPK1	1	FHL2	0	two hybrid, pull down, pull down, affinity chromatography technology	Purcell NH (2004), Purcell NH (2004), Purcell NH (2004), Purcell NH (2004)	4
KRAS	1	MAP2K1	8	genetic interference	Vizeacoumar FJ (2013)	1
PTPRR	3	MAPK1	1	pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Zuniga A (1999), Huttlin EL (2015), Chen TC (2014), St-Denis N (2016), Huttlin EL (2017)	10
PML	7	ATF2	1	pull down	Vallian S (1998)	1
MAPK1	1	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	He C (2014), He C (2014)	2
MAPK1	1	IER3	0	enzymatic study, enzymatic study	Garcia J (2002), Letourneux C (2006)	2
ATF2	1	SMAD3	1	two hybrid, pull down, affinity chromatography technology	Sano Y (1999), Sano Y (1999), Sano Y (1999)	3
MAPK1	1	SMAD1	0	enzymatic study, enzymatic study, enzymatic study	Sapkota G (2007), Alarcon C (2009), Fuentealba LC (2007)	3
MAPK3	4	RAF1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Wang J (2009), Wang J (2009), Wang J (2009)	4
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
SP1	0	TTN	102	affinity chromatography technology	Chuang JY (2012)	1
RPS6KA1	3	MAPK3	4	affinity chromatography technology	Roux PP (2003)	1
CIITA	4	MAPK3	4	affinity chromatography technology	Voong LN (2008)	1
MAPK14	0	DUSP9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Varjosalo M (2013), Huttlin EL (2015), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Camps M (1998)	6
VAV1	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Song JS (1996), Lee IS (1997)	2
RPTOR	4	EP300	36	affinity chromatography technology	Wan W (2017)	1
RARA	5	SP1	0	pull down, pull down, imaging technique, affinity chromatography technology	Suzuki Y (1999), Wu JB (2009), Wu JB (2009), Cheng YH (2008)	4
ARHGAP9	2	MAPK14	0	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4
HDAC4	10	MAPK1	1	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
BRCA1	7	TTN	102	affinity chromatography technology	Ertych N (2016)	1
MYC	2	RAF1	3	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Alexandrov I (1997), Koch HB (2007), Ivanov AA (2017)	3
CDC25C	0	MAPK3	4	affinity chromatography technology, pull down	Eymin B (2006), Eymin B (2006)	2
PML	7	IER3	0	affinity chromatography technology	Kruse ML (2005)	1
MAPK3	4	MKNK1	0	enzymatic study	Fukunaga R (1997)	1
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
PGR	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Faivre EJ (2008), Proietti CJ (2011)	2
MAPK1	1	TOP2A	2	pull down, enzymatic study	Shapiro PS (1999), Shapiro PS (1999)	2
KRAS	1	KARS	1	genetic interference	Luo J (2009)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
JUN	0	TOP2A	2	far western blotting	Kroll DJ (1993)	1
IQGAP1	1	MAP2K1	8	affinity chromatography technology	Carmon KS (2014)	1
DUSP9	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, pull down	St-Denis N (2016), Li X (2016), Camps M (1998)	3
SMAD1	0	ICK	1	two hybrid	Colland F (2004)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
CSNK2A1	15	SFPQ	2	enzymatic study	Zhang M (2011)	1
ARRB2	5	UBR5	13	affinity chromatography technology	Xiao K (2007)	1
PML	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Warren DT (2010), Lim JH (2011), Lim JH (2011)	3
FHL2	0	ARHGAP9	2	two hybrid	Rolland T (2014)	1
HDAC4	10	MAPK3	4	affinity chromatography technology, enzymatic study	Zhou X (2000), Zhou X (2000)	2
KRAS	1	SORBS3	5	affinity chromatography technology	Hein MY (2015)	1
PLA2G4A	1	MAPK3	4	affinity chromatography technology	Letsiou E (2011)	1
MAPK1	1	CSNK2A1	15	enzymatic study, affinity chromatography technology, pull down	Ji H (2009), Ji H (2009), Ji H (2009)	3
MAP2K7	5	GSK3B	1	biochemical	Wan C (2015)	1
MAPK1	1	MAPK1	1	enzymatic study, affinity chromatography technology	Kilanczyk E (2011), Varjosalo M (2013)	2
TNIP1	1	MAPK1	1	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Zhang S (2002), Zhang S (2002), Zhang S (2002), Wang J (2011), Chen Y (2015), Chen Y (2015)	6
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
MAPK3	4	BRAF	12	genetic interference, imaging technique	Guan KL (2000), Chen TC (2014)	2
MAPK3	4	STAB2	15	affinity chromatography technology, affinity chromatography technology	Kyosseva SV (2008), Kyosseva SV (2008)	2
PPARG	0	HDAC4	10	pull down, affinity chromatography technology, pull down	Franco PJ (2003), Yang Y (2011), Yang Y (2011)	3
ESR1	0	SFPQ	2	pull down	Nalvarte I (2010)	1
MAP2K1	8	MAPK3	4	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Marti A (1997), Butch ER (1996), Schaeffer HJ (1998), Yung Y (2000), Yung Y (2000), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993), Wang J (2009)	9
PTPN7	3	MAPK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology	Pettiford SM (2000), Pettiford SM (2000), Saxena M (1999), Chen TC (2014), St-Denis N (2016)	5
ARRB2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Xiao K (2007), Kim YM (2002)	2
MAPK1	1	NEK2	2	two hybrid, affinity chromatography technology, pull down	Lou Y (2004), Lou Y (2004), Lou Y (2004)	3
BRCA1	7	FHL2	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Yan J (2003), Yan J (2003), Yan JH (2003), Yan JH (2003), Yan JH (2003), Yan J (2003), Wang J (2011), Hill SJ (2014)	8
PKM	1	MAPK1	1	affinity chromatography technology, pull down, enzymatic study	Yang W (2012), Yang W (2012), Yang W (2012)	3
GSK3B	1	NCOA3	3	enzymatic study	Wu RC (2004)	1
KARS	1	MAPK1	1	affinity chromatography technology, enzymatic study	Kim DG (2012), Kim DG (2012)	2
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
DUSP1	1	MAPK1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Slack DN (2001), Slack DN (2001), Calvisi DF (2008), Brondello JM (1999), Li X (2016)	5
SNCA	0	MAPK3	4	affinity chromatography technology	Pan ZZ (2002)	1
IQGAP1	1	MAPK3	4	biochemical	Bourguignon LY (2005)	1
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
MAPK3	4	JUN	0	enzymatic study	Pulverer BJ (1991)	1
HDAC6	0	MAPK1	1	pull down, affinity chromatography technology	Williams KA (2013), Williams KA (2013)	2
MAPK1	1	STAB2	15	affinity chromatography technology, affinity chromatography technology	Kyosseva SV (2008), Kyosseva SV (2008)	2
EP300	36	PGR	1	affinity chromatography technology	Shiozawa T (2003)	1
PEBP1	0	MAPK1	1	pull down, pull down	Yeung K (2000), Yeung K (2000)	2
PML	7	BCL2	0	affinity chromatography technology	Hoetelmans RW (2004)	1
SP1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botella LM (2001), Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011), Jungert K (2006), Sanchez-Elsner T (2002)	9
RPTOR	4	ESR1	0	affinity chromatography technology, affinity chromatography technology	Alayev A (2016), Alayev A (2016)	2
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
GSK3B	1	SMAD1	0	enzymatic study, imaging technique	Fuentealba LC (2007), Chen TC (2014)	2
MAPKAPK2	1	MAPK3	4	protein complementation assay, enzymatic study	Srivastav RK (2011), Coxon PY (2003)	2
GSK3B	1	HDAC4	10	enzymatic study	Cernotta N (2011)	1
COPS6	0	MAPK1	1	affinity chromatography technology, enzymatic study	Fang L (2015), Fang L (2015)	2
BRCA1	7	IQGAP1	1	affinity chromatography technology	Ertych N (2016)	1
HDAC6	0	MAPK3	4	pull down, affinity chromatography technology, enzymatic study	Williams KA (2013), Williams KA (2013), Williams KA (2013)	3
BRCA1	7	PGR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Calvo V (2011), Ma Y (2006), Ma Y (2006), Ma Y (2006), Ma Y (2006)	5
HDAC6	0	PML	7	affinity chromatography technology	Joshi P (2013)	1
CSNK2A1	15	BRCA1	7	pull down	OBrien KA (1999)	1
MYC	2	FOXO3	1	affinity chromatography technology	Chandramohan V (2008)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
BCL2L11	4	BCL2	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen L (2005), OConnor L (1998), OConnor L (1998), Hsu SY (1998), Chen S (2009), Chen S (2009), Certo M (2006), Taylor JM (2006), Taylor JM (2006), Konopleva M (2006), Huttlin EL (2015), Rudner J (2011), Rudner J (2011), Huttlin EL (2017)	14
MAPK1	1	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
MAP2K1	8	MAP2K2	2	biochemical, affinity chromatography technology	Stewart S (1999), Huttlin EL (2017)	2
PTPN5	0	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), St-Denis N (2016), Yadav L (2017)	3
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
PPARG	0	NCOA3	3	fluorescent resonance energy transfe, pull down, two hybrid, unspecified method, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Albers M (2005), Lee G (2002), Molnar F (2005), Koppen A (2009)	6
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
MAPK3	4	GAB2	3	enzymatic study, enzymatic study	Momose H (2003), Arnaud M (2004)	2
PML	7	SYNE2	19	affinity chromatography technology, affinity chromatography technology, pull down	Warren DT (2010), Warren DT (2010), Warren DT (2010)	3
MAP3K1	4	MAP2K7	5	affinity chromatography technology, pull down	Tu Z (2003), Takekawa M (2005)	2
SP1	0	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mottet D (2009), Mottet D (2009), Wilson AJ (2008)	3
MAPK14	0	NCOA3	3	enzymatic study, enzymatic study	Wu RC (2004), Gianni M (2006)	2
TP53	0	BCL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo KS (2011), Jung JH (2011), Jung JH (2011), Mancini F (2009), Mancini F (2009)	5
DUSP3	1	MAPK3	4	enzymatic study, affinity chromatography technology	Todd JL (1999), Todd JL (1999)	2
MAPK3	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Persons DL (2000), How PC (2011), Lin C (2011), Lin C (2011)	4
PPARG	0	JUN	0	unspecified method	Lee G (2002)	1
ICK	1	RPTOR	4	enzymatic study, biochemical	Wu D (2012), Wu D (2012)	2
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
KRAS	1	SFPQ	2	genetic interference	Vizeacoumar FJ (2013)	1
BRCA1	7	PKM	1	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
MAPK1	1	GAB2	3	enzymatic study, enzymatic study	Momose H (2003), Arnaud M (2004)	2
ICK	1	TP53	0	affinity chromatography technology	Varjosalo M (2013)	1
MAPKAPK2	1	HSF1	1	enzymatic study, affinity chromatography technology	Wang X (2006), Wang X (2006)	2
DUSP4	1	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology	Chen P (2001), Cadalbert LC (2010), Li X (2016)	3
MAPK3	4	RPS6KA4	0	affinity chromatography technology	Pierrat B (1998)	1
PGR	1	UBR5	13	pull down	Henderson MJ (2002)	1
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
RARA	5	NCOA3	3	pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Torchia J (1997), Reineke EL (2007), Reineke EL (2007), Albers M (2005), Takeshita A (1997), Ferry C (2009), Gianni M (2006), Li CW (2010)	8
RPS6KA4	0	MAPK1	1	affinity chromatography technology, pull down, pull down	Tomas-Zuber M (2001), Tomas-Zuber M (2001), Smith JA (2000)	3
NOTCH1	25	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Yatim A (2012)	2
BRAF	12	KRAS	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	3
BRCA1	7	SFPQ	2	affinity chromatography technology	Ertych N (2016)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
PLA2G4A	1	MAPK1	1	affinity chromatography technology, enzymatic study	Letsiou E (2011), Boersch-Haubold AG (1998)	2
EP300	36	COPS6	0	two hybrid	Stelzl U (2005)	1
TP53	0	IQGAP1	1	affinity chromatography technology	Fogeron ML (2013)	1
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
SYNE2	19	MAPK3	4	pull down, affinity chromatography technology	Warren DT (2010), Warren DT (2010)	2
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
DCC	3	MAPK3	4	two hybrid	Forcet C (2002)	1
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
RAF1	3	PKM	1	two hybrid	Yuryev A (2003)	1
TP53	0	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Borellini F (1993), Jin W (2008), Dhar SK (2006), Lagger G (2003), Lagger G (2003), Lagger G (2003), Lagger G (2003), Sengupta S (2005), Sengupta S (2005), Lin RK (2010), Kim HA (2011), Sawaya BE (1998), St Clair S (2004), Innocente SA (2005), Innocente SA (2005), Ohlsson C (1998), Kong X (2013), Bocangel D (2009), Bocangel D (2009)	19
MAPK1	1	MAP2K7	5	unspecified method, enzymatic study, enzymatic study	Ho DT (2006), Mori S (1995), Saito T (2004)	3
TOB1	1	FHL2	0	affinity chromatography technology	Huttlin EL (2017)	1
HSF4	0	MAPK1	1	affinity chromatography technology, pull down	Hu Y (2006), Hu Y (2006)	2
DUSP6	2	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Muda M (1998), Xie XL (2015), Xie XL (2015), St-Denis N (2016), Li X (2016), Camps M (1998), Morita K (2015)	7
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
MYC	2	TOP2A	2	affinity chromatography technology	Koch HB (2007)	1
DUSP1	1	DUSP3	1	affinity chromatography technology	Li X (2016)	1
PML	7	RARA	5	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhong S (1999), Zhong S (1999), Minucci S (2000), Kraemer OH (2008), Wang K (2010), Wang K (2010), Cote S (2000), Bellodi C (2006), Villa R (2007)	9
FOXO3	1	BRCA1	7	affinity chromatography technology	Tsai WB (2008)	1
TOP2A	2	CSNK2A1	15	affinity chromatography technology, enzymatic study, biochemical	Chen MC (2011), Zhang M (2011), Wan C (2015)	3
MAPK1	1	STYX	1	affinity chromatography technology, protein complementation assay	Reiterer V (2017), Reiterer V (2017)	2
DUSP1	1	MAPK3	4	two hybrid, enzymatic study, imaging technique	Slack DN (2001), Brondello JM (1999), Chen TC (2014)	3
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
GSK3B	1	NOTCH1	25	enzymatic study, pull down	Foltz DR (2002), Foltz DR (2002)	2
MAPK1	1	MAP2K1	8	affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sanz-Moreno V (2003), Sanz-Moreno V (2003), Robinson FL (2002), Yeung K (2000), Yeung K (2000), Wunderlich W (2001), Xu Be (2001), Xu Be (2001), Chen Z (2001), Srivastav RK (2011), Kubota Y (2011), Ho DT (2003), Wang J (2009), Jahrling JB (2014)	14
MAPK1	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yang JY (2008), Yang JY (2008), Yang JY (2008)	3
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
MAPK3	4	ATF2	1	imaging technique	Chen TC (2014)	1
MAPK1	1	PPARG	0	affinity chromatography technology, affinity chromatography technology	Jahrling JB (2014), Chen F (2003)	2
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
MAPK14	0	RPS6KA4	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Pierrat B (1998), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Smith JA (2000), Huttlin EL (2017)	10
RPS6KA2	2	MAPK3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Roux PP (2003), Zhao Y (1996), Varjosalo M (2013), Chen TC (2014)	4
MAPK14	0	STAB2	15	affinity chromatography technology	Kyosseva SV (2008)	1
ELK1	2	EP300	36	genetic interference, pull down, affinity chromatography technology	Li QJ (2003), Li QJ (2003), Li QJ (2003)	3
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
RPS6KA1	3	TOB1	1	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Suzuki T (2001), Suzuki T (2001), Suzuki T (2001), Suzuki T (2001)	4
BRCA1	7	STAT5A	4	affinity chromatography technology	Vidarsson H (2002)	1
ATF2	1	CSNK2A1	15	pull down, far western blotting	Yamaguchi Y (1998), Yamaguchi Y (1998)	2
PGR	1	STAT5A	4	affinity chromatography technology, affinity chromatography technology	Cerliani JP (2011), Cerliani JP (2011)	2
MAPK1	1	ATF2	1	enzymatic study, enzymatic study, enzymatic study	Livingstone C (1995), Sanna MG (2002), Krump E (1997)	3
MAPK14	0	ATF2	1	enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Raingeaud J (1995), Raingeaud J (1995), Chen Z (2001), Pillai VB (2011), Pillai VB (2011), Gianni M (2006), Deacon K (1997), Sudo T (2000), Mo JS (2010), Uddin S (2002), Stein B (1997), Yuan ZQ (2003), Coxon PY (2003), Li H (2001), Sun L (2007), Grimsey NJ (2015), Tang J (2008), Dixon DA (2006), Chen G (2000), Frantz B (1998), Tesker M (2016), Hwang SG (2014), Camps M (1998), Bakin AV (2002), Bulavin DV (1999)	25
TNIP1	1	RARA	5	two hybrid	Gurevich I (2009)	1
MAPKAPK2	1	MAPK14	0	affinity chromatography technology, protein complementation assay, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rane MJ (2001), Srivastav RK (2011), Wang J (2011), Varjosalo M (2013), Rane MJ (2001), White A (2007), ter Haar E (2007), Varjosalo M (2013), Gum RJ (1999), Gum RJ (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Smith JA (2000), Huttlin EL (2017)	16
MAP2K1	8	BRAF	12	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, genetic interference, affinity chromatography technology	Loewenberg M (2006), Kilili GK (2010), Chen C (2008), Pardo OE (2006), Gloeckner CJ (2007), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Xie P (2009), Xie P (2009), Hart T (2015), Eisenhardt AE (2016)	12
MAPK1	1	MAPKAPK2	1	affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology	Yannoni YM (2004), Srivastav RK (2011), Powell DW (2003), Krump E (1997)	4
MAPK14	0	MAP2K7	5	enzymatic study	Tournier C (1997)	1
MAPK1	1	RARA	5	enzymatic study, affinity chromatography technology	Dwivedi PP (2002), Dwivedi PP (2002)	2
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
BRCA1	7	CDC25C	0	enzymatic study	Shabbeer S (2013)	1
BRAF	12	MAP2K7	5	enzymatic study	Eisenhardt AE (2016)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
MAPK3	4	ELK1	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, enzymatic study	Han S (2010), Zhu Z (2005), Tapinos N (2005), Coxon PY (2003), Chen TC (2014), Dixon DA (2006)	6
ARRB2	5	SYNE2	19	affinity chromatography technology	Hein MY (2015)	1
EP300	36	PKM	1	affinity chromatography technology, imaging technique	Luo W (2011), Luo W (2011)	2
MAPK3	4	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
SMAD3	1	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down	Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004), Birchenall-Roberts MC (2004)	3
DUSP2	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
CIITA	4	EP300	36	affinity chromatography technology	Beaulieu YB (2016)	1
TNFRSF1A	3	DAPK1	6	affinity chromatography technology	Henshall DC (2003)	1
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
PML	7	PKM	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shimada N (2008), Shimada N (2008), Shimada N (2008)	3
MYC	2	NEK2	2	genetic interference	Toyoshima M (2012)	1
IQGAP1	1	MAP2K2	2	affinity chromatography technology	Carmon KS (2014)	1
DUSP3	1	MAPK1	1	enzymatic study, affinity chromatography technology	Todd JL (1999), Todd JL (1999)	2
HDAC6	0	GSK3B	1	affinity chromatography technology	Beurel E (2011)	1
FHL2	0	IER3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jin H (2016), Jin H (2016), Jin H (2016), Jin H (2016)	4
MAPK1	1	CENPE	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Zecevic M (1998), Zecevic M (1998), Zecevic M (1998)	3
STAT5A	4	MAPK1	1	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Pircher TJ (1999), Pircher TJ (1999), Dinerstein-Cali H (2000), Chen TC (2014)	4
EP300	36	SREBF2	5	far western blotting	Oliner JD (1996)	1
HDAC6	0	PKM	1	affinity chromatography technology, affinity chromatography technology	New M (2013), Watson GW (2016)	2
PEA15	0	MAPK1	1	two hybrid, pull down, affinity chromatography technology	Formstecher E (2001), Formstecher E (2001), Casar B (2007)	3
MAPK1	1	SREBF2	5	enzymatic study, enzymatic study	Kotzka J (2000), Kotzka J (2004)	2
SFPQ	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Denner L (2010), Denner L (2010)	2
PTPN7	3	MAPK14	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
MAP2K1	8	PEBP1	0	pull down, pull down	Yeung K (2000), Yeung K (2000)	2
DUSP9	0	DUSP6	2	affinity chromatography technology	Li X (2016)	1
PTPN5	0	MAPK3	4	pull down, affinity chromatography technology, affinity chromatography technology	Pulido R (1998), St-Denis N (2016), Yadav L (2017)	3
MAPK1	1	UBR5	13	enzymatic study, affinity chromatography technology	Eblen ST (2003), Eblen ST (2003)	2
DAPK1	6	TSC2	17	affinity chromatography technology	Lin Y (2011)	1
ATF2	1	PKM	1	affinity chromatography technology	Lau E (2012)	1
RARA	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Subbaramaiah K (2002), Reineke EL (2007)	2
MAPK1	1	CIITA	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Voong LN (2008), Voong LN (2008), Voong LN (2008)	3
MAPK14	0	SP1	0	affinity chromatography technology	Pan W (2008)	1
CIITA	4	PPARG	0	affinity chromatography technology, affinity chromatography technology	Xu Y (2007), Xu Y (2007)	2
PML	7	MAPK3	4	affinity chromatography technology	Warren DT (2010)	1
NCOA3	3	ESR1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Wong CW (2001), Tikkanen MK (2000), Tikkanen MK (2000), Feng Q (2006), Long X (2008), Long X (2008), Dutertre M (2003), Jaber BM (2004), Torchia J (1997), Torchia J (1997), Karmakar S (2010), Takeshita A (1997), Zhao HH (2001), Wu RC (2004), Lanz RB (2010), Heck S (2009), Heck S (2009), Heck S (2009), Heck S (2009), Gunther JR (2008), Amazit L (2007), Mc Ilroy M (2006), Shao D (2004), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Chen H (1999), Rubio MF (2006), Han SJ (2016), Han SJ (2016), Li W (2015), Yi P (2015), Yi P (2017)	34
SNCA	0	MAPK1	1	affinity chromatography technology, pull down	Pan ZZ (2002), Iwata A (2001)	2
MYC	2	MAP2K7	5	genetic interference	Toyoshima M (2012)	1
DUSP2	0	DUSP3	1	affinity chromatography technology	Li X (2016)	1
MAPK14	0	RPS6KA3	2	affinity chromatography technology	Tanoue T (2001)	1
MAPK14	0	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
IQGAP1	1	MAPK1	1	biochemical, affinity chromatography technology	Bourguignon LY (2005), Bourguignon LY (2005)	2
PTPRR	3	MAPK14	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
DAPK1	6	MAPK1	1	two hybrid, pull down, affinity chromatography technology, enzymatic study	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen CH (2005)	4
TSC2	17	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mak BC (2003), Inoki K (2006), Mak BC (2003)	3
MYC	2	PML	7	affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2005), Buschbeck M (2007), Buschbeck M (2007)	3
EP300	36	STAT5A	4	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Pfitzner E (1998), Pfitzner E (1998), Pfitzner E (1998), Kotla S (2015)	4
ESR1	0	TOP2A	2	affinity chromatography technology	Tarallo R (2011)	1
PML	7	PPARG	0	two hybrid	Ravasi T (2010)	1
PGR	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Vicent GP (2006), Vicent GP (2006)	2
MYC	2	FHL2	0	affinity chromatography technology	Agrawal P (2010)	1
RARA	5	HDAC4	10	pull down	Franco PJ (2003)	1
TP53	0	TOP2A	2	affinity chromatography technology, pull down, genetic interference	Cowell IG (2000), Cowell IG (2000), Xie L (2013)	3
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
PEA15	0	MAPK3	4	two hybrid, two hybrid	Formstecher E (2001), Vinayagam A (2011)	2
BRCA1	7	TOP2A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lou Z (2005), Lou Z (2005), Lou Z (2005), Hill SJ (2014)	4
MAPK14	0	DUSP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Tanoue T (2001), Slack DN (2001), Slack DN (2001), Bandyopadhyay S (2010), Chen TC (2014), St-Denis N (2016), Li X (2016)	7
DUSP9	0	GSK3B	1	two hybrid	Wang J (2011)	1
BRCA1	7	MAPK3	4	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
TOP2A	2	TTN	102	genetic interference	Srivas R (2016)	1
MAP2K2	2	MAPK1	1	two hybrid, protein complementation assay, pull down, enzymatic study	Robinson FL (2002), Srivastav RK (2011), Ho DT (2003), Ho DT (2003)	4
EP300	36	PPARG	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology	Fajas L (2002), Iannone MA (2001), Gelman L (1999), Gelman L (1999), Gelman L (1999), Feige JN (2007), Feige JN (2007), Debril MB (2004), Subbaramaiah K (2012), Lee G (2002), Koppen A (2009), Wang C (2001)	12
MAP2K2	2	RAF1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Xia Y (1998), Wang J (2011), Wang J (2009), Johnson SE (2006)	4
TP53	0	FOXO3	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Du WW (2017), Du WW (2017)	3
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
MAP2K1	8	TTN	102	genetic interference	Srivas R (2016)	1
TP53	0	SMAD1	0	affinity chromatography technology, affinity chromatography technology	Chau JF (2012), Chau JF (2012)	2
MAPK1	1	TOB1	1	two hybrid, affinity chromatography technology, pull down, enzymatic study	Maekawa M (2002), Maekawa M (2002), Maekawa M (2002), Maekawa M (2002)	4
MAP2K2	2	MAPK3	4	two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down	Marti A (1997), Butch ER (1996), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993)	5
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
BCL2	0	KRAS	1	affinity chromatography technology, affinity chromatography technology	Wang X (2009), Wang X (2009)	2
MAPK1	1	NCOA3	3	enzymatic study, enzymatic study	Wu RC (2004), Gianni M (2006)	2
SMAD3	1	SREBF2	5	affinity chromatography technology, affinity chromatography technology	Grimsby S (2004), Grimsby S (2004)	2
EP300	36	NOTCH1	25	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Hao L (2010), Popko-Scibor AE (2011), Popko-Scibor AE (2011), Popko-Scibor AE (2011)	4
EP300	36	SMAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pearson KL (1999), Nakashima K (1999), Nakashima K (1999), Jeon EJ (2006), Jun JH (2010), Weng Q (2012)	6
SP1	0	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kardassis D (1999), Hung JJ (2006), Chen BK (2007), Chen BK (2007), Chen BK (2007)	5
BRAF	12	MAP2K2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	3
TSC2	17	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Finlay GA (2004), Finlay GA (2004), Finlay GA (2004), York B (2005)	4
GAB2	3	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
ARRB2	5	MAP2K1	8	affinity chromatography technology	Luttrell LM (2001)	1
PTPN7	3	MAPK3	4	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Pettiford SM (2000), Saxena M (1999), Saxena M (1999), St-Denis N (2016)	4
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
PML	7	JUN	0	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vallian S (1998), Yasuda S (1999), Salomoni P (2005), Salomoni P (2005), Seo SR (2006), Seo SR (2006), Seo SR (2006)	7
MAPK3	4	DUSP9	0	imaging technique, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), St-Denis N (2016), Li X (2016)	3
MAPK1	1	TTN	102	enzymatic study, genetic interference	Raskin A (2012), Srivas R (2016)	2
MAPK3	4	IER3	0	affinity chromatography technology	Garcia J (2002)	1
TOB1	1	SMAD3	1	affinity chromatography technology	Xiong B (2006)	1
ARHGAP9	2	MAPK1	1	pull down, pull down, affinity chromatography technology, x-ray crystallography	Ang BK (2007), Ang BK (2007), Ang BK (2007), Ang BK (2007)	4
PEA15	0	RPS6KA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Vaidyanathan H (2003), Vaidyanathan H (2003), Vaidyanathan H (2003)	3
MAPK14	0	CSNK2A1	15	affinity chromatography technology, pull down	Sayed M (2000), Sayed M (2000)	2
UBR5	13	GSK3B	1	affinity chromatography technology, pull down	Hay-Koren A (2011), Hay-Koren A (2011)	2
BRCA1	7	RPTOR	4	affinity chromatography technology	Ertych N (2016)	1
CSNK2A1	15	MYC	2	enzymatic study	Channavajhala P (2002)	1
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
MAPK14	0	CDC25C	0	enzymatic study, pull down	Bulavin DV (2001), Bulavin DV (2001)	2
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
MAPK1	1	TNFRSF1A	3	enzymatic study, affinity chromatography technology, pull down	Frankel SK (2001), Ibeas E (2009), Ibeas E (2009)	3
MAPK3	4	SP1	0	enzymatic study, enzymatic study	Milanini-Mongiat J (2002), Cramer T (2008)	2
MAPK1	1	GSK3B	1	affinity chromatography technology, pull down, enzymatic study	Ding Q (2005), Ding Q (2005), Ding Q (2005)	3
RPS6KA3	2	MAPK3	4	affinity chromatography technology, imaging technique	Zhao Y (1996), Chen TC (2014)	2
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
BRCA1	7	KARS	1	affinity chromatography technology	Ertych N (2016)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
CDC25C	0	HDAC4	10	affinity chromatography technology	Boldt K (2016)	1
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
TOB1	1	SMAD1	0	affinity chromatography technology	Yoshida Y (2000)	1
ESR1	0	MAPK1	1	pull down, enzymatic study	Metivier R (2002), Tremblay A (2001)	2
MYC	2	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
GSK3B	1	CIITA	4	enzymatic study	Xu Y (2008)	1
ESR1	0	FHL2	0	two hybrid	Kobayashi S (2004)	1
PPARG	0	SFPQ	2	pull down, affinity chromatography technology, two hybrid	Tsukahara T (2013), Tsukahara T (2013), Tsukahara T (2013)	3
RPS6KA1	3	ESR1	0	enzymatic study	Joel PB (1998)	1
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
MAPK1	1	SMAD3	1	enzymatic study, affinity chromatography technology	Alarcon C (2009), Brown KA (2008)	2
ITGB6	2	MAPK1	1	affinity chromatography technology, unspecified method	Ahmed N (2002), Ahmed N (2002)	2
ESR1	0	HDAC4	10	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	van Rooij E (2010), Leong H (2005), Leong H (2005), Leong H (2005), Leong H (2005)	5
BRAF	12	RPTOR	4	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	BCL2	0	enzymatic study, affinity chromatography technology	Tamura Y (2004), Tamura Y (2004)	2
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
SMAD3	1	FOXO3	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Seoane J (2004), Fu G (2011), Bollinger LM (2014)	3
BCL2	0	BRCA1	7	fluorescent resonance energy transfe, affinity chromatography technology	Laulier C (2011), Laulier C (2011)	2
MAPK14	0	JUN	0	enzymatic study	Thakur N (2014)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
CIITA	4	PML	7	imaging technique	Forlani G (2017)	1
DUSP2	0	MAPK14	0	affinity chromatography technology	Li X (2016)	1
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
GSK3B	1	SNCA	0	pull down	Kawakami F (2011)	1
MAP3K1	4	TNIP1	1	enzymatic study	Charlaftis N (2014)	1
EP300	36	HSF1	1	affinity chromatography technology	Huang C (2017)	1
RPS6KA1	3	RPS6KA3	2	affinity chromatography technology	Varjosalo M (2013)	1
DAPK1	6	MAPK3	4	two hybrid, pull down, affinity chromatography technology, imaging technique	Chen CH (2005), Chen CH (2005), Chen CH (2005), Chen TC (2014)	4
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
DUSP4	1	MAPK1	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
PEBP1	0	RAF1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yeung K (2000), Yeung K (2000), Yeung K (2000), Lorenz K (2003), Zhao J (2011), Zhao J (2011)	6
RPS6KA3	2	ESR1	0	affinity chromatography technology	Clark DE (2001)	1
RPS6KA1	3	RPTOR	4	enzymatic study	Carriere A (2008)	1
MAPK14	0	DUSP6	2	affinity chromatography technology	Tanoue T (2001)	1
FHL2	0	TTN	102	two hybrid, pull down	Lange S (2002), Lange S (2002)	2
EP300	36	ATF2	1	biochemical	Duyndam MC (1999)	1
MYC	2	MAPK3	4	pull down	Jin Z (2004)	1
SNCA	0	ELK1	2	affinity chromatography technology, affinity chromatography technology	Iwata A (2001), Iwata A (2001)	2
ARRB2	5	PKM	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
VAV1	2	MAP2K1	8	affinity chromatography technology	Song JS (1996)	1
DUSP4	1	MAPK14	0	pull down, affinity chromatography technology	Chen P (2001), Li X (2016)	2
MAPK1	1	SORBS3	5	enzymatic study, affinity chromatography technology	Mitsushima M (2004), Mitsushima M (2004)	2
MAP2K1	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karandikar M (2000), Karandikar M (2000), Tu Z (2003)	3
MAPK3	4	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	He C (2014), He C (2014)	2
DCC	3	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Tcherkezian J (2010), Tcherkezian J (2010)	2
PTPN5	0	MAPK14	0	affinity chromatography technology	Li X (2016)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
ARRB2	5	SFPQ	2	affinity chromatography technology	Xiao K (2007)	1
SFPQ	2	SP1	0	affinity chromatography technology	Tyson-Capper AJ (2009)	1
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
PML	7	CSNK2A1	15	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Stehmeier P (2009), Hung MS (2010), Hung MS (2010), Scaglioni PP (2006)	5
KRAS	1	PML	7	affinity chromatography technology	Hein MY (2015)	1