PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKG1	3	PTK2	2	affinity chromatography technology	Huttlin EL (2017)	1
PRKG1	3	TBXA2R	1	enzymatic study	Reid HM (2003)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
AR	3	RAF1	3	biochemical	Kupfer SR (1993)	1
PRKG1	3	PPP1R12B	2	two hybrid	Surks HK (1999)	1
RGS2	2	PRKG1	3	pull down, affinity chromatography technology	Tang KM (2003), Tang KM (2003)	2
PRKG1	3	AR	3	enzymatic study	Zhou L (2013)	1
PRKG1	3	ANXA7	0	enzymatic study	Caohuy H (2001)	1
PSMC5	4	PRKG1	3	affinity chromatography technology	Huttlin EL (2017)	1
LMO2	2	PRKG1	3	two hybrid	Rolland T (2014)	1
PRKG1	3	SELL	0	enzymatic study	Kilian K (2004)	1
PRKG1	3	HDAC1	4	enzymatic study	Tsai SC (2002)	1
OAS2	2	PRKG1	3	affinity chromatography technology	Huttlin EL (2017)	1
PRKG1	3	CREB1	1	enzymatic study	Gudi T (2000)	1
ITPR1	25	MRVI1	2	affinity chromatography technology, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000)	2
CORO2B	2	PRKG1	3	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	GTF2I	1	affinity chromatography technology	Wen YD (2003)	1
PRKG1	3	FAM124A	3	two hybrid	Rolland T (2014)	1
PPP1R12A	6	PPP1R12B	2	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
PSMC5	4	TNNT1	0	two hybrid, two hybrid	Rual JF (2005), Yu H (2011)	2
TBXA2R	1	RAF1	3	affinity chromatography technology	Yan W (2006)	1
PRKG1	3	WDR77	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhou L (2013), Zhou L (2013), Zhou L (2013), Zhou L (2013)	4
PRKG1	3	NPR1	1	two hybrid	Airhart N (2003)	1
PRKG1	3	TNNT1	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yuasa K (1999), Yuasa K (1999), Yuasa K (1999), Yuasa K (1999), Yuasa K (1999)	5
WDR77	2	AR	3	pull down, affinity chromatography technology	Hosohata K (2003), Li Y (2013)	2
PRKG1	3	PPP1R12A	6	pull down	Surks HK (1999)	1
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
RAF1	3	PRKG1	3	affinity chromatography technology	Zaragoza C (2002)	1
PRKG1	3	TRIM39-RPP21	0	two hybrid	Roberts JD (2007)	1
PRKG1	3	ITPR1	25	enzymatic study, affinity chromatography technology, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000)	3
HECW2	13	PRKG1	3	affinity chromatography technology	Lu L (2013)	1
GTF2I	1	PRKG1	3	pull down, affinity chromatography technology	Casteel DE (2002), Casteel DE (2002)	2
PRKG1	3	MRVI1	2	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000), Schlossmann J (2000), Ammendola A (2001), Ammendola A (2001)	6
PRKG1	3	ZKSCAN1	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKG1	3	ZNF646	12	two hybrid	Rolland T (2014)	1