PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKDC	12	CIB1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wu X (1997), Wu X (1997), Lee GE (2004), Lee GE (2004)	4
TP53	0	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Al Rashid ST (2005), Al Rashid ST (2005)	2
PRKDC	12	RPA2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Shao RG (1999), Shao RG (1999), Shao RG (1999), Wu X (2006), Zernik-Kobak M (1997), Chan DW (2000), Marechal A (2014), Fried LM (1996)	8
TP53	0	DCLRE1C	3	genetic interference	Xie L (2013)	1
XRCC5	5	TOP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sand-Dejmek J (2011), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	5
SIRT6	2	XRCC6	3	affinity chromatography technology, affinity chromatography technology	McCord RA (2009), McCord RA (2009)	2
H2AFX	1	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang X (2010), Huttlin EL (2015), Huttlin EL (2017)	3
RPA2	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shao RG (1999), Shao RG (1999), Marechal A (2014), Wan C (2015)	4
ILF2	3	XRCC5	5	affinity chromatography technology	Shi L (2007)	1
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
MDC1	8	PRKDC	12	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Lou Z (2004), Lou Z (2004), Lou Z (2004), Lou Z (2004)	4
PRKDC	12	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, affinity chromatography technology	Shao RG (1999), Drouet J (2005), Gottlieb TM (1993), Shamanna RA (2011), Shamanna RA (2011), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Hein MY (2015)	9
ERG	1	ILF2	3	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
ERG	1	TOP1	1	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
ILF2	3	XRCC6	3	affinity chromatography technology	Shi L (2007)	1
TP53	0	TOP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Gobert C (1999), Mao Y (2002), Restle A (2008)	3
PRKDC	12	ILF2	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ting NS (1998), Ting NS (1998), Shi L (2007), Karmakar S (2010)	4
XRCC5	5	DCLRE1C	3	affinity chromatography technology, affinity chromatography technology	Drouet J (2006), Drouet J (2006)	2
XRCC6	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Feki A (2005), Feki A (2005)	2
TELO2	6	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2010), Takai H (2010), Takai H (2007), Takai H (2007)	5
MDC1	8	XRCC5	5	pull down, affinity chromatography technology	Lou Z (2004), Lou Z (2004)	2
MDC1	8	H2AFX	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, imaging technique	Stewart GS (2003), Stewart GS (2003), Xu X (2003), Lukas C (2004), Strauss C (2011), Strauss C (2011), Stewart GS (2003), Stewart GS (2003), Stewart GS (2003), Pan MR (2011), Pei H (2011), Campbell SJ (2010), Rassoolzadeh H (2015)	13
ERG	1	ILF3	5	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
RPA2	0	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	ILF3	5	affinity chromatography technology	Marechal A (2014)	1
XRCC5	5	PRKDC	12	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology	Jin S (1997), Matheos D (2002), Gell D (1999), Drouet J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Olsen BB (2012), Olsen BB (2012), Sand-Dejmek J (2011), Sartorius CA (2000), Sartorius CA (2000), Drouet J (2006), Drouet J (2006), Sibanda BL (2010), Wan C (2015), Hein MY (2015)	17
PRKDC	12	TP53	0	unspecified method, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Kim ST (1999), Goudelock DM (2003), Yavuzer U (1998), Maiti AK (2010), Shieh SY (1997), Chan DW (2000), Kim ST (1999), Sakaguchi K (1998), Borcherds W (2014)	9
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
ERG	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Brenner JC (2011), Brenner JC (2011)	2
SIRT6	2	PRKDC	12	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	McCord RA (2009), McCord RA (2009), McCord RA (2009), Simeoni F (2013)	4
TOP1	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	4
PPP6C	7	PPP6R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zeng K (2010), Douglas P (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017)	8
ERG	1	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Brenner JC (2011), Brenner JC (2011), Wang S (2014), Wang S (2014)	4
PRKDC	12	PPP6R2	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Douglas P (2010), Douglas P (2010), Douglas P (2010), Huttlin EL (2017)	4
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
PRKDC	12	C1D	0	two hybrid, pull down, enzymatic study, affinity chromatography technology	Yavuzer U (1998), Yavuzer U (1998), Yavuzer U (1998), Yavuzer U (1998)	4
SIRT6	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Thirumurthi U (2014), Thirumurthi U (2014), Thirumurthi U (2014)	3
SIRT6	2	XRCC5	5	affinity chromatography technology, affinity chromatography technology	McCord RA (2009), McCord RA (2009)	2
PRKDC	12	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference	Feng J (2004), Feng J (2004), Feng J (2004), Dragoi AM (2005), Dragoi AM (2005), Dragoi AM (2005), Shen JP (2017)	7
RPA2	0	ILF2	3	affinity chromatography technology	Marechal A (2014)	1
ILF3	5	ILF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reichman TW (2002), Shi L (2007), Shamanna RA (2011), Havugimana PC (2012), Karmakar S (2010), Karmakar S (2010), Karmakar S (2010), Huttlin EL (2015), Huttlin EL (2017), Zhu X (2016), Zhu X (2016)	11
H2AFX	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Mischo HE (2005), Mischo HE (2005), Heo K (2008), Heo K (2008), Heo K (2008), Lee HS (2010), Kobayashi J (2012), Huttlin EL (2017)	8
H2AFX	1	XRCC5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo K (2008), Heo K (2008), Sand-Dejmek J (2011)	3
PRKDC	12	H2AFX	1	enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Park EJ (2003), Mischo HE (2005), Heo K (2008), Heo K (2008), Li A (2010), Kim K (2012)	6
PRKDC	12	DCLRE1C	3	pull down, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Ma Y (2002), Ma Y (2002), Ma Y (2002), Zhang X (2004), Ma Y (2005), Drouet J (2006), Drouet J (2006)	7
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
XRCC6	3	ILF3	5	affinity chromatography technology, affinity chromatography technology	Shamanna RA (2011), Shamanna RA (2011)	2
PRKDC	12	PPP6C	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Douglas P (2010), Douglas P (2010), Douglas P (2010), Couzens AL (2013), Yadav L (2017)	5
PRKDC	12	ILF3	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ting NS (1998), Ting NS (1998), Shamanna RA (2011), Shamanna RA (2011)	4
RPA2	0	XRCC5	5	affinity chromatography technology	Marechal A (2014)	1
DCLRE1C	3	PPP6R2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOP1	1	PRKDC	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	5
ERG	1	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Brenner JC (2011), Brenner JC (2011)	2