Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
KMT2E rs117986340 GG duloxetine efficacy yes Patients with the GG genotype had a greater % decrease in the Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline as compared to those with the GT genotype. Note that in the initial GWAS analysis, this variant only reached the "suggestive" (p<5E-5) threshold. Genotype GG is associated with increased response to duloxetine in people with Depressive Disorder, Major as compared to genotype GT. 28696415 1449750812