PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF2	1	MAPK9	3	imaging technique	Chen TC (2014)	1
TUBA1A	13	TUBB	3	biochemical, biochemical, pull down	Havugimana PC (2012), Kristensen AR (2012), Wang W (2014)	3
HDAC5	4	HNRNPL	3	affinity chromatography technology	Greco TM (2011)	1
HSP90AA1	7	PKN1	4	affinity chromatography technology	Taipale M (2012)	1
PKN1	4	HIST2H3C	0	enzymatic study	Metzger E (2008)	1
HDAC5	4	TUBA1A	13	affinity chromatography technology	Greco TM (2011)	1
PKN1	4	AKAP9	13	two hybrid, pull down, affinity chromatography technology	Takahashi M (1999), Takahashi M (1999), Takahashi M (1999)	3
KBTBD8	2	PKN1	4	affinity chromatography technology	Werner A (2015)	1
GOLGA2	2	PKN1	4	two hybrid	Rolland T (2014)	1
PKN1	4	CDC25C	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Isagawa T (2005), Isagawa T (2005), Isagawa T (2005), Isagawa T (2005)	4
PKN1	4	MAP2K6	2	affinity chromatography technology	Takahashi M (2003)	1
KRT15	2	NEFL	1	two hybrid	Rolland T (2014)	1
MYC	2	PDK1	1	genetic interference	Toyoshima M (2012)	1
HNRNPL	3	MBP	0	affinity chromatography technology	Fei T (2017)	1
KRT31	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
COG6	1	PKN1	4	affinity chromatography technology	Huttlin EL (2017)	1
CDR2	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
HNRNPL	3	MAP2K3	1	affinity chromatography technology	Fei T (2017)	1
HSP90AA1	7	ACTN1	5	affinity chromatography technology	Falsone SF (2005)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
NTRK1	1	PA2G4	1	affinity chromatography technology	Emdal KB (2015)	1
PKN1	4	PKN1	4	enzymatic study	Gotoh Y (2004)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
CD81	0	TUBA1A	13	affinity chromatography technology	Perez-Hernandez D (2013)	1
KRT31	0	PKN1	4	two hybrid	Rolland T (2014)	1
PKN1	4	TNFRSF1B	4	affinity chromatography technology, pull down, pull down	Kato T (2008), Kato T (2008), Kato T (2008)	3
SSX2IP	0	TUBA1A	13	affinity chromatography technology	Gupta GD (2015)	1
PKN1	4	ZNF282	1	two hybrid	Vinayagam A (2011)	1
PKN1	4	NEUROD2	0	two hybrid, affinity chromatography technology, pull down	Shibata H (1999), Shibata H (1999), Shibata H (1999)	3
KMT2A	58	ASH2L	2	affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, biochemical, pull down	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Blobel GA (2009), Butler JS (2011), Mak AB (2010), Dharmarajan V (2012), Patel A (2014), Tang Z (2013), Li Y (2016), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017)	13
MAPK12	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
HDAC5	4	PA2G4	1	affinity chromatography technology	Greco TM (2011)	1
PKN1	4	RBBP5	3	imaging technique	Kim JY (2014)	1
MAP2K3	1	MAP2K6	2	genetic interference, affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Huber TB (2001), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	5
PKN1	4	KMT2A	58	imaging technique	Kim JY (2014)	1
PLAUR	0	PKN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDK1	1	PKN1	4	affinity chromatography technology	Flynn P (2000)	1
MAPK12	1	MAP2K6	2	enzymatic study	Takahashi M (2003)	1
PKN1	4	CDR2	1	two hybrid, two hybrid	Takanaga H (1998), Rolland T (2014)	2
PKN1	4	TOM1L1	1	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
WDR5	2	PDPK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
GOLGA2	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
PKN1	4	CCDC85B	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
HSP90AA1	7	TUBB	3	affinity chromatography technology	Skarra DV (2011)	1
PKN1	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
PKN1	4	MARCKS	0	enzymatic study	Palmer RH (1996)	1
TUBB	3	MYC	2	affinity chromatography technology	Conacci-Sorrell M (2010)	1
RHOA	0	PKN1	4	pull down, two hybrid, pull down, two hybrid, far western blotting, pull down, x-ray crystallography	Riento K (2003), Riento K (2003), Alberts AS (1998), Flynn P (1998), Flynn P (1998), Flynn P (1998), Maesaki R (1999)	7
TNFRSF1B	4	TRAF2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Song HY (1995), Song HY (1995), Takeuchi M (1996), Hostager BS (2002), Rothe M (1996), Marsters SA (1997), Carpentier I (2008), Rothe M (1995), Park YC (1999), Boucher LM (1997), Rothe M (1994), Rothe M (1994)	13
MYC	2	NTRK1	1	genetic interference	Toyoshima M (2012)	1
PDPK1	0	PKN1	4	two hybrid, pull down	Balendran A (2000), Balendran A (2000)	2
KRT31	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
NTRK1	1	TUBB	3	affinity chromatography technology	Emdal KB (2015)	1
KRT15	2	PKN1	4	two hybrid	Rolland T (2014)	1
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
CDC25C	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
NTRK1	1	ACTN1	5	affinity chromatography technology	Emdal KB (2015)	1
FUOM	1	PKN1	4	affinity chromatography technology	Huttlin EL (2017)	1
NEFH	4	NEFL	1	biochemical, affinity chromatography technology	Athlan ES (1997), Huttlin EL (2017)	2
KRT15	2	SSX2IP	0	two hybrid	Rolland T (2014)	1
PKN1	4	TUBB	3	affinity chromatography technology	Ren Y (2003)	1
PKN1	4	TRAF2	1	two hybrid, affinity chromatography technology, pull down	Gotoh Y (2004), Gotoh Y (2004), Gotoh Y (2004)	3
CD81	0	PKN1	4	affinity chromatography technology	Perez-Hernandez D (2013)	1
TRAF2	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
PKN1	4	ACTN1	5	affinity chromatography technology, affinity chromatography technology	Feng S (2002), Feng S (2002)	2
HDAC5	4	HSP90AA1	7	affinity chromatography technology	Greco TM (2011)	1
PKN1	4	HIST1H1A	0	enzymatic study	Turner EC (2011)	1
MAPK11	1	MAPT	1	enzymatic study	Goedert M (1997)	1
AEN	0	SSX2IP	0	two hybrid	Rolland T (2014)	1
TUBA1A	13	MAPT	1	affinity chromatography technology	Seiberlich V (2012)	1
RBBP5	3	KMT2A	58	affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Blobel GA (2009), Dou Y (2005), Dharmarajan V (2012), Hu D (2013), Tang Z (2013), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017)	11
WDR5	2	SSX2IP	0	two hybrid	Rolland T (2014)	1
PKN1	4	MAP2K3	1	affinity chromatography technology	Takahashi M (2003)	1
MAPK11	1	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
PKN1	4	SPRR2D	1	two hybrid	Vinayagam A (2011)	1
CASP3	0	PKN1	4	enzymatic study	Takahashi M (1998)	1
HDAC6	0	TUBB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Z (2010), Zhao Z (2010), New M (2013), Watson GW (2016)	4
MID1	1	TUBB	3	affinity chromatography technology	Gholkar AA (2016)	1
SSX2IP	0	ACTN1	5	affinity chromatography technology, pull down	Asada M (2003), Asada M (2003)	2
HNRNPL	3	TOM1L1	1	affinity chromatography technology	Fei T (2017)	1
PA2G4	1	HIST1H1A	0	affinity chromatography technology	Squatrito M (2004)	1
PKN1	4	TRAF1	0	enzymatic study	Kato T (2008)	1
HDAC6	0	MAPT	1	pull down, affinity chromatography technology, affinity chromatography technology	Ding H (2008), Ding H (2008), Yu Q (2018)	3
PKN1	4	BUD23	0	two hybrid	Wang J (2011)	1
CCNT2	4	PKN1	4	two hybrid, pull down, affinity chromatography technology	Cottone G (2006), Cottone G (2006), Cottone G (2006)	3
TBXA2R	1	PKN1	4	two hybrid, pull down, affinity chromatography technology	Turner EC (2011), Turner EC (2011), Turner EC (2011)	3
RHEX	0	PKN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
NEFL	1	VIM	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Goehler H (2004), Huttlin EL (2017), Boldt K (2016)	3
PKN1	4	PPM1G	1	biochemical	Wan C (2015)	1
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
PKN1	4	VIM	0	two hybrid, enzymatic study, two hybrid	Matsuzawa K (1997), Matsuzawa K (1997), Rolland T (2014)	3
HNRNPL	3	PKN1	4	affinity chromatography technology	Fei T (2017)	1
PLD1	5	RHOA	0	enzymatic study, pull down, affinity chromatography technology, pull down, unspecified method	Genth H (2003), Genth H (2003), Cai S (2001), Cai S (2001), Cai S (2001)	5
MAPK11	1	PPM1G	1	biochemical	Wan C (2015)	1
MYC	2	CDR2	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	ODonovan KJ (2010), Okano HJ (1999), Okano HJ (1999), Okano HJ (1999), Okano HJ (1999)	5
KMT2A	58	HIST2H3C	0	enzymatic study	Wu L (2011)	1
NTRK1	1	WDR5	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
HSP90AA1	7	MARCKS	0	biochemical	Havugimana PC (2012)	1
MAPK9	3	PPM1A	1	biochemical	Wan C (2015)	1
NTRK1	1	HDAC6	0	affinity chromatography technology	Emdal KB (2015)	1
PKN1	4	MAPK12	1	enzymatic study, affinity chromatography technology	Takahashi M (2003), Takahashi M (2003)	2
PKN1	4	HDAC6	0	affinity chromatography technology, pull down	Jiang Q (2008), Jiang Q (2008)	2
HNRNPL	3	MAPT	1	affinity chromatography technology	Fei T (2017)	1
PKN1	4	WDR5	2	imaging technique	Kim JY (2014)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
WDR5	2	KMT2A	58	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Song JJ (2008), Avdic V (2011), Paggetti J (2010), Mak AB (2010), Dharmarajan V (2012), Dharmarajan V (2012), Zhang P (2012), Senisterra G (2013), Tang Z (2013), Shinsky SA (2014), Huttlin EL (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017), Hauri S (2016)	19
HDAC5	4	WDR5	2	affinity chromatography technology	Greco TM (2011)	1
NTRK1	1	MARCKS	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PKN1	4	affinity chromatography technology	Emdal KB (2015)	1
CD81	0	HIST1H1A	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
PKN1	4	MAPT	1	enzymatic study	Taniguchi T (2001)	1
PKN1	4	MBP	0	enzymatic study	Isagawa T (2005)	1
ACTN1	5	TUBA1A	13	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Cerecedo D (2008), Cerecedo D (2008), Cerecedo D (2008)	3
PKN1	4	ASH2L	2	imaging technique	Kim JY (2014)	1
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
MYC	2	MAP2K3	1	genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Toyoshima M (2012), Ivanov AA (2017), Ivanov AA (2017), Ivanov AA (2017)	4
MID1	1	HSP90AA1	7	affinity chromatography technology	Aranda-Orgilles B (2008)	1
PKN1	4	TUBA1A	13	affinity chromatography technology	Ren Y (2003)	1
RBBP5	3	HIST2H3C	0	pull down	Goo YH (2003)	1
CASP3	0	VIM	0	enzymatic study	Walsh JG (2008)	1
NEFH	4	PKN1	4	pull down, two hybrid	Mukai H (1996), Mukai H (1996)	2
TUBA1A	13	MYC	2	affinity chromatography technology	Conacci-Sorrell M (2010)	1
PKN1	4	NEFL	1	two hybrid, pull down	Mukai H (1996), Mukai H (1996)	2
PA2G4	1	VIM	0	affinity chromatography technology	Liu Z (2009)	1
RBBP5	3	TUBA1A	13	biochemical	Goo YH (2003)	1
CD81	0	TUBB	3	affinity chromatography technology	Perez-Hernandez D (2013)	1
MAGEA10	1	PKN1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACTN1	5	CD81	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Perez-Hernandez D (2013), Perez-Hernandez D (2013), Perez-Hernandez D (2013)	3
NTRK1	1	VIM	0	affinity chromatography technology	Emdal KB (2015)	1
PKN1	4	PPM1A	1	biochemical	Wan C (2015)	1
CD81	0	HIST2H3C	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
TBXA2R	1	RHOA	0	affinity chromatography technology	Turner EC (2011)	1
TNFRSF1B	4	TRAF1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Marsters SA (1997), Mosialos G (1995), Mosialos G (1995), Boucher LM (1997), Rothe M (1994), Kato T (2008)	6
AEN	0	PKN1	4	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	TUBA1A	13	affinity chromatography technology	Emdal KB (2015)	1
PLAUR	0	TUBA1A	13	affinity chromatography technology	Huttlin EL (2015)	1
NTRK1	1	PPM1G	1	affinity chromatography technology	Emdal KB (2015)	1
HDAC6	0	TUBA1A	13	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Matsuyama A (2002), Hubbert C (2002), Zhao Z (2010), Zhao Z (2010), New M (2013)	6
MID1	1	PKN1	4	two hybrid	Rolland T (2014)	1
RHEX	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CASP3	0	MAPK9	3	enzymatic study	Enomoto A (2003)	1
HDAC5	4	TUBB	3	affinity chromatography technology	Greco TM (2011)	1
PDPK1	0	PA2G4	1	affinity chromatography technology	Behrends C (2010)	1
PKN1	4	SSX2IP	0	two hybrid	Rolland T (2014)	1
PLD1	5	PKN1	4	affinity chromatography technology, pull down	Oishi K (2001), Oishi K (2001)	2
MAPK9	3	CDC25C	0	enzymatic study	Manke IA (2005)	1
PA2G4	1	PKN1	4	affinity chromatography technology	Liu Z (2009)	1
HDAC6	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Kekatpure VD (2009), Rao R (2008), Bali P (2005), Kovacs JJ (2005), New M (2013), Rao R (2012), Kovacs JJ (2005)	7
WDR5	2	MYC	2	affinity chromatography technology	Carugo A (2016)	1
MAPK9	3	PKN1	4	biochemical	Havugimana PC (2012)	1
HIST1H1A	0	WDR5	2	affinity chromatography technology, affinity chromatography technology	Kim K (2013), Kim K (2013)	2
PKN1	4	MAPK11	1	affinity chromatography technology	Takahashi M (2003)	1
MYC	2	PKN1	4	genetic interference	Toyoshima M (2012)	1
PKN1	4	HOMER3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PKN1	4	HDAC5	4	enzymatic study	Harrison BC (2010)	1