PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CD93	1	ARHGAP15	4	two hybrid	Bohlson SS (2005)	1
SNCA	0	ARHGAP15	4	pull down	Schnack C (2008)	1
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
ARHGAP15	4	DHPS	3	affinity chromatography technology	Huttlin EL (2017)	1
APP	1	ARHGAP15	4	pull down	Virok DP (2011)	1
ARHGAP15	4	KDM1A	2	two hybrid	Weimann M (2013)	1
PRNP	4	ARHGAP15	4	pull down	Satoh J (2009)	1
ARHGAP15	4	RAC1	7	pull down	Seoh ML (2003)	1